- Imperfections & Redness
The life of the skin is not a long calm river
On a daily basis, the skin can experience changes in state, appearance and sensitivity. Its reactivity can increase, appear redness, imperfections as well as feelings of overheating, tightness, irritation or even tingling... So many manifestations that give it a hard time and ruin our lives, all the more when real pathologies set in (acne, rosacea).
The top of zinc: the essential against imperfections
Used by dermatologists to target inflammation and healing, zinc is a key ingredient in solutions prescribed for problem skin (blemishes, acne). For our Clear Skin Complex, we have selected a third generation salt: zinc gluconate. Its elemental zinc content (14.4%) is more than compensated by its high bioavailability. But this salt is especially acclaimed for its perfect solubility in water, thus avoiding the digestive discomfort that can be caused by other salts such as citrate, lactate or even zinc oxide.
Cilantro to strike a chore
To support zinc in soothing sensitive skin, we have selected SepiblissTM, a patented oil from coriander seeds (Coriandrum sativum) titrated at 60% in omega-12. It is this active ingredient recognized for its auxiliary role in the anti-inflammatory response that allows SepiblissTM to display more than tangible clinical results:
- 25% redness from the 1st month of use*
- reduced reactivity of sensitive skin*
- and 60% of testers confirm these results**.
**Clinical study with 90 people - 2 month.
Redness, discomfort, blemishes, feeling of tightness… Our Clear Skin Complex formula
targets the problems and manifestations of sensitive skin.
- Coriander oil owes its virtues on the inflammatory response to its richness in petroselinic acid (titrated at 60%).
- Zinc helps maintain normal skin and protect cells against oxidative stress.
- Zinc contributes to the normal metabolism of fatty acids.
The benefits of coriander oil
With its coriander oil, our ingredient SepiblissTM helps to improve and preserve the comfort of sensitive skin. Its effectiveness has been demonstrated: from 1 month, redness is reduced by 25%* and after 2 months, 60%** of volunteers feel their skin is less reactive.
*Clinical study with 90 volunteers - 1 month
*Clinical study with 90 volunteers - 1 months
The benefits of zinc
With proven benefits in dermatology, zinc is a commonly used ingredient in acne solutions. It is also very often found associated with drug treatments at higher doses (30mg/d) than what Nutra authorizes (25mg/d maximum and reference intake of 10mg/d).
The benefits of sensitive skin
All skin types have common needs: cleansing, hydration and protection. On the other hand, so-called “reactive” skin requires special attention and appropriate care. Weakened by internal factors and by their environment, these skins generally have increased sensitivity and their reactions are exacerbated: redness, irritation, tightness, feelings of discomfort. And this hyper-responsiveness can manifest itself in certain conditions like acne and rosacea. If cosmetic treatments can provide suitable answers, Nutraceuticals have, in addition to Zinc, a second generation of ingredients such as SepiblissTM, recognized and scientifically studied for effective solutions from the inside.
When to take The Clear Skin Complex?
- The Clear Skin Complex should be taken 1 hour before a meal, in the morning with breakfast, at noon with lunch or in the evening with dinner.
How many capsules?
- Children: Not recommended.
- Teenagers: From 14 years old, 1 capsule per day.
- Adults: 2 capsules per day.
Duration of a take ?
- To comply with the conditions of the clinical studies, our Clear Skin Complex must be taken for a minimum of 1 month, at the rate of 2 capsules per day.
How to take The Clear Skin Complex?
- The capsules are to be taken with a large glass of water, quite simply.
Duration of a vial
- One bottle of Le Complexe Peau Nette lasts 30 days.
Precautions of use
- Consume as part of a healthy, balanced diet.
- Do not exceed the recommended daily doses.
- Not recommended for children under 10 years old.
- Pregnant and breastfeeding women should take the advice of a doctor before any supplementation
- Store in a dry place away from light and heat.
- Keep out of reach of children.
Nutritional value For 2 capsules % of ARs* Chia seed oil 430 - Coriander seed oil (SepiblissTM) 200 - Zinc (Zinc gluconate) 10 100
Ingredients: Chia oil (Salvia hispanica); SepiblissTM [coriander seed oil (Coriandrum sativum)]; Coating agent: hydroxypropylmethylcellulose; Zinc gluconate.
SepiblissTM is a registered trademark of Seppic.
The underside of the skin [1,2]
The skin is made up of 3 superimposed layers from the outermost to the deepest:
- The epidermis: in direct contact with the outside, the epidermis gives the skin its barrier effect and its impermeability. It is not vascularized and renews itself on average in 21 days by naturally eliminating its dead cells to make room for new cells.
- The dermis: the dermis is the support mattress of the skin. Its composition (rich in water, collagen, hyaluronic acid and elastin) gives the skin its strength but also its suppleness and elasticity. Its specialized cells called fibroblasts are the source of most of its constituents such as collagen and hyaluronic acid.
- The hypodermis: it is the interface tissue between the skin and our organs. Formed from adipose tissue, it is made up of specialized cells called adipocytes, capable of storing and releasing accumulated lipids according to our needs and serving as energy reserves.
The skin subjected to many tests
Taking care of your skin often rhymes with taking care of your youthfulness: slowing down the effects of time, avoiding accelerated aging, delaying the appearance of wrinkles and slackening of tissues. But our skin can experience many other inconveniences.
Overall, our skin is subject to 2 types of potential aggression factors:
- external factors related to our environment such as the sun and its UV radiation, the first and most important factor to which our skin is exposed. But also pollution, the climate, the use of cosmetic products, improper and irregular cleaning.
- internal factors related to our physiology such as hormonal variations, aging and stress.
Sensitivity and reactivity of the skin [4.5]
If globally, the degree of skin sensitivity is a story of individuals, sensitive or reactive skin is characterized precisely by the fact that it reacts abnormally to stimuli (climate, cosmetic products, pollution, etc.) to which it does not would not react normally. Reactive skin is therefore skin whose sensitivity or tolerance threshold is lowered.
This hyperreactivity is linked to a dysfunction of the barrier function of the skin to which is generally added an inflammatory phenomenon which can be punctual or chronic.
These characteristics can result in:
- physical manifestations: redness, roughness to the touch, dryness and imperfections.
- sensations: tingling, heating, tightness.
If skin sensitivity can manifest itself all over the body, it is particularly on the face that sensitive skin is truly characterized because it is the most exposed.
Sensitive or reactive skin is an important issue. It is estimated that 50% to 80% of the French population is affected, with varying degrees of sensitivity (sensitive to very sensitive skin) [6,7].
Acne and rosacea, sensitive pathologies
If sensitive skin is not a pathology in itself, conversely, skin subject to a pathology can turn out to be sensitive and reactive, in response to this pathology. Examples include acne and rosacea known for their recurrence and prevalence. With these pathologies, the skin usually becomes hyper-reactive.
- Acne: Acne is characterized by a dysfunction of the pilosebaceous follicles at the base of the hairs. Each hair in the skin is connected to a sebaceous gland responsible for producing sebum, a mixture of water and lipids that protects and lubricates the skin. The gland develops at puberty and this is usually when acne appears, and follicle dysfunction occurs. At the time of puberty, male sex hormones (present in both men and women) particularly increase the secretion of sebum. In excess, the latter can no longer flow normally. Added to this is an infection with a bacterium, propionibacterium acnes. By accumulating, sebum and bacteria promote the formation of comedones (pimples) clogging the pores of the skin. The depth and evolution of comedones can then lead to scars giving the skin a “pockmarked” appearance [1,8,9]. If the acne is more or less severe during puberty, it generally progresses in the young adult stage towards recovery. In the case of moderate to severe acne, the pathology is commonly treated in order to limit its psychological impact (self-esteem) and the associated inconveniences such as painful sensations, hyper-reactivity of the skin. Acne can then persist, especially in women, in response to hormonal variations (menstruation, pregnancy). In France, it is estimated that 60.7% of 15-24 year olds  and 41% of adult women (25-40 years old) suffer from acne
- Rosacea: Rosacea or couperose is a skin condition involving the blood vessels of the skin. This pathology is characterized by dilation of the vessels favoring the appearance of redness (or erythrosis). It can also be characterized by the additional appearance of papules (pimples), comparable to acne. The causes are still poorly known, but several factors would play on its appearance such as significant temperature variations and very strong emotions [1,12]. Rosacea is usually accompanied by an exacerbated sensitivity of the skin. Worldwide, 5% of the adult population is affected by rosacea .
Fight against skin reactivity
Taking care of your skin starts with a good diet. The literature on skin health  indicates that, in general, our diet must cover the skin's basic nutrient needs (vitamins, minerals, essential fatty acids) to ensure its proper functioning (internal defenses, structure , hydration…) and healthy skin. And if our food "gaps" are often pointed out in the problems of sensitive skin or even acne, in reality, they only play a very minimal role. On a daily basis, it is possible to prevent hyper-reactivity with good practices such as moderating exposure to the sun, favoring cosmetic products that are gentle on the skin, avoiding rubbing the face with a towel, or even the use of cosmetic treatments. specifically designed for sensitive skin. These formulas are based on ingredients validated for their benefits: soothe inflammation, moisturize or mask redness.
On the Nutraceutical side, many formulas have proven themselves on the skin. Collagen, hyaluronic acid or even micronutrients are recognized when taken orally for results on the signs of aging or skin hydration. And to maintain healthy, clear skin, one ingredient is particularly recognized: zinc.
We also sometimes find Zinc associated with antibiotics in treatments against severe acne or rosacea.
Focus on Zinc
Zinc is a trace element involved in many cellular functions. It is found almost everywhere in the body: bones, teeth, hair, skin, liver, muscles, white blood cells and testicles. The literature on the relationship between zinc intake and skin health is extensive. Several publications report the positive effects of zinc on skin problems including acne [15–20]. It is in response to this work that certain medicinal solutions have appeared to treat acne. The doses and forms of zinc studied vary according to the problems. Several clinical studies have been conducted on the oral intake of 30 mg zinc gluconate per day over 3 months in the context of inflammatory acne . The results demonstrated a clear and significant improvement in the inflammatory state of the skin. If such doses are not possible in Nutra, zinc supplementation nevertheless proves to be beneficial in the case of relatively moderate acne (in the first instance or not of a treatment or even in the second instance in support after a treatment).
Our food supplement for sensitive skin (acne, rosacea, etc.)
Our Clear Skin Complex formula has been designed for the care of sensitive and hyper-reactive skin, prone to redness and unpleasant sensations.
For this, it combines the best in a DuoCaps® double-encapsulation capsule:
- The small capsule: it contains 5 mg of zinc-element provided by zinc gluconate, the most clinically documented form (2 capsules therefore make 10 mg, or 100% of AR).
- The large capsule: it contains 215 mg of chia seed oil and 100 mg of SepiblissTM, a patented coriander seed oil proven to be effective in studies on skin reactivity and sensitivity.
Focus on SepiblissTM, a coriander oil dedicated to sensitive skin:
SepiblissTM is an exceptional French coriander seed oil (Coriandrum sativum). This oil is rich in petroselinic acid (omega-12 titrated at 60%), an active ingredient known for its support of the anti-inflammatory response [22–24]. SepiblissTM was the subject of a clinical study over 56 days in 90 women with sensitive and reactive skin. This work has demonstrated that an oral intake of 200 mg per day of SepiblissTM significantly reduces redness, tingling and itching by -25% after one month and by -36% after 2 months. Results confirmed by women: for 60% of them, their skin is less reactive after 2 months of use . The mode of action of this ingredient is supported by in vitro data revealing 2 potential mechanisms at the origin of its benefits:
Overall, our ingredient SepiblissTM targets sensitive skin and the manifestations that result from it, whatever the origin of their hyper-reactivity (environmental aggressions or skin conditions such as acne and rosacea).(https://www.nutraceuticalsworld.com/issues/2021-Beauty-IO/view_features/coriander-seed-oil-beauty-from-within-for-sensitive-skin/).
- an anti-inflammatory action,
- a neuro-soothing action.
Références(1) CCMO L’ESSENTIEL SUR LA PEAU ET LA DERMATOLOGIE; p. 39;.(2) Hani, Y.; Mandy, A.; Sandeep, S. Anatomy, Skin (Integument), Epidermis. Available online: www.ncbi.nlm.nih.gov/books/NBK470464/.(3) Parrado, C.; Mercado-Saenz, S.; Perez-Davo, A.; Gilaberte, Y.; Gonzalez, S.; Juarranz, A. Environmental Stressors on Skin Aging. Mechanistic Insights. Front. Pharmacol. 2019, 10, 759, doi:10.3389/fphar.2019.00759.(4) Primavera, G.; Berardesca, E. Sensitive Skin: Mechanisms and Diagnosis. Int. J. Cosmet. Sci. 2005, 27, 1–10, doi:10.1111/j.1467-2494.2004.00243.x.(5) Misery, L.; Bataille, A.; Talagas, M.; Le Gall-Ianotto, C.; Fouchard, M.; Huet, F.; Ficheux, A.-S.; Roudot, A.-C.; Fluhr, J.W.; Brenaut, E. Sensitive Skin Syndrome: A Low-Noise Small-Fiber Neuropathy Related to Environmental Factors? Front. Pain Res. 2022, 3, 853491, doi:10.3389/fpain.2022.853491.(6) Duarte, I.; Silveira, J.E.P.S.; Hafner, M. de F.S.; Toyota, R.; Pedroso, D.M.M. Sensitive Skin: Review of an Ascending Concept. An. Bras. Dermatol. 2017, 92, 521–525, doi:10.1590/abd1806-4841.201756111.(7) Farage, M.A. The Prevalence of Sensitive Skin. Front. Med. 2019, 6, 98, doi:10.3389/fmed.2019.00098.(8) Masterson, K.N. Acne Basics: Pathophysiology, Assessment, and Standard Treatment Options. J. Dermatol. Nurses Assoc. 2018, 10, S2–S10, doi:10.1097/JDN.0000000000000361.(9) Dréno, B. What Is New in the Pathophysiology of Acne, an Overview. J. Eur. Acad. Dermatol. Venereol. 2017, 31, 8–12, doi:10.1111/jdv.14374.(10) Heng, A.H.S.; Chew, F.T. Systematic Review of the Epidemiology of Acne Vulgaris. Sci. Rep. 2020, 10, 5754, doi:10.1038/s41598-020-62715-3.(11) Poli, F.; Dreno, B.; Verschoore, M. An BlackwellScienceLtd Epidemiological Study of Acne in Female Adults: Results of a Survey Conducted in France. 2001, 5.(12) Alexis, A.F.; Callender, V.D.; Baldwin, H.E.; Desai, S.R.; Rendon, M.I.; Taylor, S.C. Global Epidemiology and Clinical Spectrum of Rosacea, Highlighting Skin of Color: Review and Clinical Practice Experience. J. Am. Acad. Dermatol. 2019, 80, 1722-1729.e7, doi:10.1016/j.jaad.2018.08.049.(13) Gether, L.; Overgaard, L.K.; Egeberg, A.; Thyssen, J.P. Incidence and Prevalence of Rosacea: A Systematic Review and Meta-Analysis. Br. J. Dermatol. 2018, doi:10.1111/bjd.16481.(14) Michalak, M.; Pierzak, M.; Kręcisz, B.; Suliga, E. Bioactive Compounds for Skin Health: A Review. Nutrients 2021, 13, 203, doi:10.3390/nu13010203.(15) Bae, Y.S.; Hill, N.D.; Bibi, Y.; Dreiher, J.; Cohen, A.D. Innovative Uses for Zinc in Dermatology. Dermatol. Clin. 2010, 28, 587–597, doi:10.1016/j.det.2010.03.006.(16) Bagherani, N.; R Smoller, B. An Overview of Zinc and Its Importance in Dermatology-Part II: The Association of Zinc with Some Dermatologic Disorders. Glob. Dermatol. 2016, 3, 337–350, doi:10.15761/GOD.1000186.(17) Dhaliwal, S.; Nguyen, M.; Vaughn, A.; Notay, M.; Chambers, C.; Sivamani, R. Effects of Zinc Supplementation on Inflammatory Skin Diseases: A Systematic Review of the Clinical Evidence. Am J Clin Dermatol 2020, 21, 21–39.(18) Gupta, M.; Mahajan, V.K.; Mehta, K.S.; Chauhan, P.S. Zinc Therapy in Dermatology: A Review. Dermatol. Res. Pract. 2014, 2014, 1–11, doi:10.1155/2014/709152.(19) Yee, B.E.; Richards, P.; Sui, J.Y.; Marsch, A.F. Serum Zinc Levels and Efficacy of Zinc Treatment in Acne Vulgaris: A Systematic Review and Meta‐analysis. Dermatol. Ther. 2020, 33, doi:10.1111/dth.14252.(20) Tolino, E.; Skroza, N.; Mambrin, A.; Proietti, I.; Bernardini, N.; Balduzzi, V.; Marchesiello, A.; Di Fraia, M.; Michelini, S.; Potenza, C. An Open-Label Study Comparing Oral Zinc to Lymecycline in the Treatment of Acne Vulgaris. J. Clin. AESTHETIC Dermatol. 2021, 14.(21) Cervantes, J.; Eber, A.E.; Perper, M.; Nascimento, V.M.; Nouri, K.; Keri, J.E. The Role of Zinc in the Treatment of Acne: A Review of the Literature. Dermatol. Ther. 2018, 31, e12576, doi:10.1111/dth.12576.(22) Sahib, N.G.; Anwar, F.; Gilani, A.-H.; Hamid, A.A.; Saari, N.; Alkharfy, K.M. Coriander (Coriandrum Sativum L.): A Potential Source of High-Value Components for Functional Foods and Nutraceuticals- A Review : CORIANDER AS FUNCTIONAL FOOD AND NUTRACEUTICAL. Phytother. Res. 2013, 27, 1439–1456, doi:10.1002/ptr.4897.(23) Uitterhaegen, E.; Sampaio, K.; Delbeke, E.; De Greyt, W.; Cerny, M.; Evon, P.; Merah, O.; Talou, T.; Stevens, C. Characterization of French Coriander Oil as Source of Petroselinic Acid. Molecules 2016, 21, 1202, doi:10.3390/molecules21091202.(24)Kern, C.; Gombert, C.; Roso, A.; Garcia, C. Soothing Effect of Virgin Coriander Seed Oil on Sensitive Skin. OCL 2020, 27, 49, doi:10.1051/ocl/2020043.(25) Kern, C.; Gombert, C.; Roso, A.; Garcia, C. Effect of the Supplementation of Virgin Coriander Seed Oil on Reducing Reactivity in Healthy Women with Sensitive Skin: A Randomized Double-Blind Placebo-Controlled Pilot Clinical Study. Food Nutr. Res. 2022, 66, doi:10.29219/fnr.v66.7730.
Analyzes Check for YES Microbiological x Heavy metals x Pesticides x Allergens x Gluten x PHAs x Other EtO
A question ?Our experts answer all your questions.
How quickly can the effects be seen?
According to clinical data on our ingredients, it takes 1 month of use to obtain a 25% reduction in skin redness. However, the effects are gradual.
Is the product effective for acne, eczema, couperose / rosacea...?
The Clear Skin Complex targets the manifestations of sensitive skin: tingling, redness, burning, dryness. And if these manifestations can appear in various pathologies such as acne, rosacea, it is important to emphasize that our formula will not act on the very causes of these pathologies.
I am taking antibiotic treatment, can I take Le Complexe Peau Nette?
Yes, if the treatment does not present a contraindication to zinc supplementation. If in doubt, do not hesitate to ask your doctor or dermatologist.
Is Le Complexe Peau Nette suitable for hormonal acne?
Yes, because our formula targets the manifestations of acne whatever its origin. But depending on the severity of your acne, our formula may not be enough. And drugs with higher zinc dosages may be needed. In any case, do not exceed the recommended dose of 2 capsules per day. And in case of severe acne, we advise you to consult a health professional.
Is it effective on my whole body?
Yes, because our formula does not act specifically locally. Thus, although sensitivity issues particularly concern the face, our formula can bring an overall improvement to the body.
Is it compatible with an anti-acne treatment?
The various acne treatments are not insignificant (antibiotics, Roaccutane). Thus, if you wish to combine our Clear Skin Complex with your current treatment, we advise you to seek the advice of your prescribing practitioner.
I already take 3 capsules of Multi a day, won't that be too much zinc?
For those over 18, you will need to increase to 1 capsule of Multi per day if you take our Clear Skin complex. For teenagers, you will have to stop the Multi for the time you take the Clear Skin Complex. You can then resume your 3 capsules of Multi per day.
Can I go to the sun while taking it?
Yes, taking the formula is not contraindicated in case of sun exposure. Be careful however: UVs are not recommended in case of sensitive skin.
Can I take it at the same time as other skin formulas such as Le Collagen, Le Solaire or L'Acide Hyaluronique?
Yes, it is quite possible to combine Le Complexe Peau Nette with other skin formulas. In an interesting and complementary way, Hyaluronic Acid contributes to the hydration of the skin while Le Solaire aims to improve its tan while protecting it from oxidative damage from UVs which can increase its sensitivity.
Can I use it to strengthen my immune defenses?
Yes, because zinc contributes to the normal functioning of the immune defences. However, you will find in our range more targeted formulas with Le Multi [hyperlink] or Le Zinc [future hyperlink].
Where do our ingredients come from?
Encapsulation (putting into capsules) - LonzaColmar, France
Lonza is a benchmark player in capsules and encapsulation. Its patented DuoCaps® technology is one of the few to combine materials that are difficult to reconcile, such as oils and powders
Coriander oil - SeppicParis, France
Seppic offers active and functional ingredients for food supplements with a high quality approach and objective benefits. The SepiblissTM ingredient comes from coriander seeds harvested in France.
Zinc gluconate - IsaltisThenioux, France
For more than 50 years, Isaltis has been a renowned French player in the production of high purity organic mineral salts, particularly in terms of nutrition.
Chia oil - AgrofünVillemur-sur-Tarn, France
Agrofün offers quality ingredients for the food industry. Committed to the diversification of local crops in France, Agrofün promotes agricultural materials and ensures that the French agricultural fabric is maintained.