





Articulations & Antioxidant
The only curcumin that dared to compare itself to others!
Ensuring the correct absorption of curcuminoids means guaranteeing the traditional benefits of Turmeric on the articular and antioxidant spheres. The comparative clinical study on TurmiPure Gold® Bio demonstrated superior bioavailability compared to other patents for vectorized curcumin.
Controlled bioavailability
Ensuring good bioavailability means avoiding high doses of Turmeric while ensuring its effectiveness. The toxicological clinical study on TurmiPure Gold® Bio has demonstrated its good tolerance and long-term safety. This study also allowed deciphering the mechanism of absorption and metabolism of curcumin.
A Curcuma Made In France
TurmiPure Gold® is a patented extract made in France from rhizomes (roots) cultivated in India and carefully selected and analyzed by our partner. It is extracted with water and ethanol without the use of chemical solvents.
The multiple benefits of turmeric have been recognized for millennia.
Several health claims are recognized today. Turmeric:
- Helps protect cells against oxidative stress,
- Helps maintain healthy joints and bones,
- Helps maintain joint flexibility.
Regarding the digestive benefits of turmeric, we recommend a simple food turmeric and not an augmented formula like ours.
When do I take your Curcuma2?
Curcuma² should be taken at the end of the meal, ideally breakfast.
How many capsules do I have to take?
- Children: Not recommended.
- Adolescents: Not recommended.
- Adults: 1 to 2 capsules per day.
- Pregnant and lactating women: Not recommended.
- 2 capsules during periods of intensive training or joint discomfort.
Duration of a dose
Take a 2 week break every 8 weeks from Turmeric² supplementation.
How to take the capsules?
It's very simple. You have to take your capsules with a big glass of water.
Duration of a bottle
The bottle of Cucurma² lasts 30 days at 2 capsules per day.
Precaution of use
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Food supplement based on turmeric, to be used in addition to a healthy and balanced diet.
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Do not exceed the recommended daily doses.
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Not suitable for pregnant and breastfeeding women.
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Not suitable for children under 18.
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Not suitable for people with liver or biliary disorders.
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People on anticoagulants should seek advice from their doctor before any supplementation.
Storage conditions
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Store in a dry place away from light and heat.
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Keep out of the reach of children.
For 1 capsule Quantity TurmiPure Gold® Bio Turmeric Extract 150 mg including Curcuminoids 45 mg
For 2 capsules Quantity TurmiPure Gold® Organic Turmeric Extract 300 mg including Curcuminoids 90 mg Ingredients: TurmiPure Gold® * [turmeric rhizome extract * (Curcuma longa L), acacia gum, sunflower oil, quillaja bark extract], Acacia fiber, Coating agent: hydroxypropylmethylcellulose, E, Rice extract *.
* Ingredients from Organic Farming. TurmiPure Gold® is a registered trademark of Naturex.Origin and "starification"
Curcuma longa is a rhizome (an underground stem) of the Zingiberacae (or ginger) family. It contains curcuminoids, which are polyphenols, responsible for the yellow-orange pigmentation in turmeric. For twenty years, the frequency of publications on turmeric has continued to grow [1], revealing a real craze for this plant, which has become known throughout the world.
In the Ayurvedic tradition (from South Asia), it is used as a medicinal herb to allow good mobility of the joints, or to preserve beautiful skin from various problems. [2]. But in general, turmeric is widely known and recognized for its antioxidant and soothing properties, especially on the intestinal sphere for example [3] ...
Curcumin, nutraceutical asset
But what does turmeric contain and who makes it so popular? Among its many molecules of interest, the famous curcuminoids (1 to 6%) remain those that have attracted the most attention of researchers. There are in fact 3 sub-categories of bioactive molecules within this family [1]:
- Curcumin (60-70% of curcuminoids),
- Demethoxycurcumin,
- Bis-Demethoxycurcumin.
Curcumin has widely recognized antioxidant activity [4]. An antioxidant, by its definition, is able to act in very small amounts on the oxidative attacks that the body must face. This is why turmeric is a real asset in the fight against the premature aging of our cells.
Choosing your turmeric
But if it sounds so much like an ideal nutraceutical, why isn't it so easy to effectively upgrade turmeric capsules?
Well, because there is a "But", and it's a big one. Indeed, scientific data has undoubtedly highlighted the low bioavailability of curcumin and that the conjugated form (weakly bioactive) appeared as the most abundant form in plasma (after oral intake) while only a very low percentage of the free form (bioactive) is thought to pass into the blood [5–8]. In addition, pure curcumin is insoluble in water and in many fats, giving it poor absorption and bioavailability (absorption capacity) characteristics. Basically, while curcumin is beneficial, taking turmeric capsules does not guarantee sufficient assimilation by the body, let alone the desired effects.
Assessment of the races, several nutraceutical challenges arose:
- Optimize the concentration of curcuminoids,
- And increase the bioavailability, that is, the ability of curcuminoids to pass into the blood so that they can reach target tissues.
It is in this context that Nutri & Co has carefully considered the best solutions to optimize the effectiveness of turmeric.
In this new version of our Curcuma², we have combined an extract that has demonstrated its high bioavailability compared to standard extracts and its tolerance: TurmiPure Gold® Bio. In addition to the consistent results in the studies to its credit, its characteristics make it an ideal candidate: 30% curcuminoids and vectorization (emulsion and microgranulation).
In the clinical pharmacological study conducted on TurmiPure Gold® Bio, the intake via 300 mg of the latter was equivalent to 2264 mg of turmeric with 95% curcuminoids + black pepper (piperine), i.e. a 22 times greater bioavailability [9 ].
If we systematically refer to curcumin as the main molecule of interest in turmeric (the majority among the curcuminoid family), its stability profile suggests that its benefits are driven by some of its metabolites. This same clinical pharmacological study has precisely demonstrated the fate of curcumin and its effective and predominant transformation into tetrahydrocurcumin (THC), one of the metabolites most highlighted by scientists today.
Turmeric is often the subject of controversy in terms of safety. The clinical intestinal tolerance study carried out on TurmiPure Gold® Bio on 60 subjects proved its tolerance and safety at an intake of 1000 mg (ie 300 mg of curcuminoids) [10].
Turmeric and benefits
In general, it should be noted that the mechanisms of action of bioactive molecules in turmeric and in particular curcumin (more widely studied) are poorly described. However, here are the scientific leads that we have in hand. Turmeric owes its beneficial action to 3 major different processes:
- Decreased histamine production,
- Strengthening the action of the adrenal hormone (kidneys), cortisol,
- Improves circulation by removing toxins from the joints.
It is through these processes that turmeric has a positive effect on joint comfort [11]. While today it is difficult to rule on precise mechanisms, some clinical studies have shed light on the beneficial roles of turmeric and its bioactive compounds. Clinical studies have shown the beneficial value of pure curcumin as an antioxidant as well as a cell defense agent (abnormal cell proliferation) [12–14].
Beyond these properties, scientific publications summarizing work on turmeric have identified that it could have effects on [15–18]:
- Improvement of gastrointestinal disorders,
- Protection of the liver,
- Microbial defenses,
- Neurological functions.
In conclusion, in the context of joint discomfort (the main cause of the intake of turmeric), the clinical research base on the effects of turmeric suggests that supplementation may be beneficial, even if several variable criteria when studying these compounds in clinical work prevent us from drawing firm conclusions on the mechanism of action: chemical stability, water solubility, targeted activities, bioavailability, metabolism, applied dosage… [1]. In contrast, the body of evidence points to scientific evidence for the positive relationship between turmeric and joint comfort [19-22]. [10].Publications
- Nelson, K.M.; Dahlin, J.L.; Bisson, J.; Graham, J.; Pauli, G.F.; Walters, M.A. The Essential Medicinal Chemistry of Curcumin: Miniperspective. J. Med. Chem. 2017, 60, 1620–1637.
- Cronin, J.R. Curcumin: Old Spice Is a New Medicine. Altern. Complement. Ther. 2003, 9, 34–38.
- Hewlings, S.; Kalman, D. Curcumin: A Review of Its’ Effects on Human Health. Foods 2017, 6, 92.
- He, Y.; Yue, Y.; Zheng, X.; Zhang, K.; Chen, S.; Du, Z. Curcumin, Inflammation, and Chronic Diseases: How Are They Linked? Molecules 2015, 20, 9183–9213.
- Goel, A.; Kunnumakkara, A.B.; Aggarwal, B.B. Curcumin as “Curecumin”: From kitchen to clinic. Biochem. Pharmacol. 2008, 75, 787–809.
- Anand, P.; Kunnumakkara, A.B.; Newman, R.A.; Aggarwal, B.B. Bioavailability of Curcumin: Problems and Promises. Mol. Pharm. 2007, 4, 807–818.
- Shoji, M.; Nakagawa, K.; Watanabe, A.; Tsuduki, T.; Yamada, T.; Kuwahara, S.; Kimura, F.; Miyazawa, T. Comparison of the effects of curcumin and curcumin glucuronide in human hepatocellular carcinoma HepG2 cells. Food Chem. 2014, 151, 126–132.
- Vareed, S.K.; Kakarala, M.; Ruffin, M.T.; Crowell, J.A.; Normolle, D.P.; Djuric, Z.; Brenner, D.E. Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects. Cancer Epidemiol. Biomarkers Prev. 2008, 17, 1411–1417.
- Kumar, D.; Jacob, D.; Ps, S.; Maliakkal, A.; Nm, J.; Kuttan, R.; Maliakel, B.; Konda, V.; Im, K. Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: A randomised double-blind crossover study. J. Funct. Foods 2016, 22, 578–587.
- Pandaran Sudheeran, S.; Jacob, D.; Natinga Mulakal, J.; Gopinathan Nair, G.; Maliakel, A.; Maliakel, B.; Kuttan, R.; Im, K. Safety, Tolerance, and Enhanced Efficacy of a Bioavailable Formulation of Curcumin With Fenugreek Dietary Fiber on Occupational Stress: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. J. Clin. Psychopharmacol. 2016, 36, 236–243.
- Akram, M.; Ahmed, A.; Usmanghani, K.; Hannan, A.; Mohiuddin, E.; Asif, M. CURCUMA LONGA AND CURCUMIN: A REVIEW ARTICLE. ROM J BIOL – PLANT BIOL 2010, 55, 65–70.
- Ireson, C.; Orr, S.; Jones, D.J.L.; Verschoyle, R.; Lim, C.-K.; Luo, J.-L.; Howells, L.; Plummer, S.; Jukes, R.; Williams, M.; et al. Characterization of Metabolites of the Chemopreventive Agent Curcumin in Human and Rat Hepatocytes and in the Rat in Vivo, and Evaluation of Their Ability to Inhibit Phorbol Ester-induced Prostaglandin E2 Production. Cancer Res. 2001, 61, 1058–1064.
- Sikora, E.; Scapagnini, G.; Barbagallo, M. Curcumin, inflammation, ageing and age-related diseases. Immun. Ageing 2010, 7, 1.
- Sandhu, K.V.; Sherwin, E.; Schellekens, H.; Stanton, C.; Dinan, T.G.; Cryan, J.F. Feeding the microbiota-gut-brain axis: diet, microbiome, and neuropsychiatry. Transl. Res. 2017, 179, 223–244.
- Hatcher, H.; Planalp, R.; Cho, J.; Torti, F.M.; Torti, S.V. Curcumin: From ancient medicine to current clinical trials. Cell. Mol. Life Sci. 2008, 65, 1631–1652.
- Singletary, K. Turmeric: An Overview of Potential Health Benefits. Nutr. Today 2010, 45, 216–225.
- Gupta, S.C.; Patchva, S.; Aggarwal, B.B. Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials. AAPS J. 2013, 15, 195–218.
- Labban, L. Medicinal and pharmacological properties of Turmeric (Curcuma longa): A review. Int J Pharm Biomed Sci 2014, 5, 17–23.
- Yue, G.G.L.; Chan, B.C.L.; Hon, P.-M.; Kennelly, E.J.; Yeung, S.K.; Cassileth, B.R.; Fung, K.-P.; Leung, P.-C.; Lau, C.B.S. Immunostimulatory activities of polysaccharide extract isolated from Curcuma longa. Int. J. Biol. Macromol. 2010, 47, 342–347.
- Madhu, K.; Chanda, K.; Saji, M.J. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology 2013, 21, 129–136.
- Bethapudi, B.; Murugan, S.; Illuri, R.; Mundkinajeddu, D.; Velusami, C. Bioactive turmerosaccharides from Curcuma longa Extract (NR-INF-02): Potential ameliorating effect on osteoarthritis pain. Pharmacogn. Mag. 2017, 13, 623.
- Velusami, C.C.; Richard, E.J.; Bethapudi, B. Polar extract of Curcuma longa protects cartilage homeostasis: possible mechanism of action. Inflammopharmacology 2018, 26, 1233–1243.
Our promise of transparency also involves the publication of quality analyzes:
A question ?
Our experts answer all your questions.Why do we focus everything on absorption?
As for nutrients and plant active ingredients, absorption refers to their ability to pass the intestinal barrier to reach the blood plasma and make themselves available to the cells of the body.
In its natural state, curcumin exhibits very low absorption. To benefit from its effectiveness, you must ingest at least 40 grams of powdered turmeric, or 2 grams of turmeric concentrated at 95% curcuminoids ... This is considerable!
It was therefore essential to choose a curcumin grafted to a transporter capable of significantly increasing its absorption. Our choice fell on TurmiPure Gold®. Containing 30% curcuminoids, it has 22 times greater absorption than a conventional turmeric - piperine combination.
Do I have to take it continuously?
The ideal is to take Curcuma² when you need it, when you experience joint discomfort for example. If this discomfort persists, the intake can be continued with a break of 2 weeks every 8 weeks.
Why doesn't your formula contain black pepper?
Many turmeric preparations highlight the addition of black pepper (piperine) in order to increase the absorption of curcumin. However, an independent study in 2012 demonstrated the very low interest of such a preparation. Indeed, piperine (active ingredient of black pepper) does not increase the assimilation of curcumin but the intestinal permeability. This involves two phenomena:
- The absorption of all the elements present in the digestive tract, including harmful elements such as heavy metals or nutrients not completely digested,
- Curcumin is largely absorbed in its conjugated form. As this undigested form is not bioactive, the body struggles to use it correctly.
Is there a risk of excess of Curcuma²?
To date, there is no definitive evidence on the potential harmful effects of turmeric. Doses of up to 8 grams of turmeric powder per day are safe, according to the American Association of Pharmaceutical Scientists. TurmiPure Gold® benefits from a clinical toxicological study which has demonstrated its safety at more than 1 g / day. Our recommended daily dose is 300 mg per day, which is three times less than clinically demonstrated tolerance. In all cases, people on anticoagulants should seek advice from their doctor before supplementation.
Are athletes concerned by Curcuma²?
Insofar as some athletes put their joints to the test, they are obviously concerned by Curcuma². They are used to taking care of their joints, in particular thanks to food supplements based on chondroitin or glucosamine. If they are effective, their action will take a long time to be put in place. To provide a quick solution, turmeric has established itself in recent years as a Nutra of choice.
Can I give your Curcuma² to my dog?
Unfortunately no. Although Curcuma² is also documented for its effects on the joints of our best friends, its veterinary use is strictly regulated. Thus, food supplements based on Turmeric are reserved for humans only. If you want to give turmeric to your pet, talk to your veterinarian, he will direct you to specific and suitable brands and products.
Where do our ingredients come from?

TurmiPure Gold® Bio - Naturex India
Created in 1992, Naturex is an international leader in the development of high-performance natural ingredients in the fields of food, health and beauty. It is the second player to have developed a vectorized and organic curcumin, but the first to have proven harmless through a clinical pharmacokinetic study.
Capsule filling and packaging - MGDBrandérion, France
Located in the heart of Morbihan, MGD Nature benefits from over 20 years of expertise in the formulation of food supplements from natural ingredients and under controlled manufacturing conditions of quality and safety.