Our Rhodiola Bio is a formula designed to better manage stress and its harm on the cognitive sphere: mental fatigue, anxiety, mood and emotional disorders ...

• Rhodiola helps the body adapt to emotional stress, and helps reduce fatigue associated with excessive mental work.
• Rhodiola contributes to optimal intellectual and cognitive activity.
• Vitamin B6 contributes to normal psychological functions.
• Vitamin B2 contributes to a normal energy metabolism.

Stress and its impact on our body

When it sets in, stress becomes deleterious for our body. Indeed, stress that becomes chronic impacts the homeostasis of the body and increases the risk of developing certain pathological manifestations (by weakening our immune defenses in particular). If the first solutions often revolve around well-being and stress management, the benefits of Nutra are also recognized, particularly through the use and study of certain so-called adaptogenic plants such as Rhodiola.

When to take our Rhodiola Bio?

Rhodiola Bio should be taken at breakfast. 

How many capsules?

• Children : Not recommended. 
• Adolescents: Not recommended.
• Adults: 2 to 3 capsules per day. 

Duration of one intake

• Our Rhodiola Bio is taken during 1 month minimum and until 3 months maximum, at a rate of 2 to 3 capsules per day. To make a pause of 1 month between 2 catches. Its taking can be repeated several times in the year.  

How to take Rhodiola Bio?

• The capsules are to be taken with a large glass of water, simply.

Description of Rhodiola rosea [1]

Rhodiola is a member of the Crassulaceae family, which has about 200 different species of Rhodiola around the world. If 20 of them are used in traditional Asian medicine, the most known for its health benefits is Rhodiola rosea also called pink rhodiola, pink orphan, fragrant orphan or golden root. This species grows in the mountainous regions of Europe (including France), Asia and America. Known since the Vicking medicine, Rhodiola rosea is one of the most popular adaptogenic plants, especially in Russia where we find the origin of its extensive literature. In Siberia, its root was widely used by the population for its ability to increase the resistance and performance of the body in the face of extreme conditions. Today, its benefits are described in many pharmaceutical books on the psychic sphere and it is also widely used in food supplement formulas. It should be noted that the different species of Rhodiola can be confused and all do not meet the same regulations. It is therefore important to check the botanical origin of the plant before choosing its formula.

Chemical composition of Rhodiola rosea [1] [2]

The rhizomes (roots) of Rhodiola or pink orpin contain essential oils, sterols, glycosides, organic acids (gallic acid for example), phenolic compounds ... 

The organic compounds of interest of Rhodiola rosea are part of the category of flavonoids (phyhylethanoids, phenylpropanoids and their glycosides). 

The 2 major active ingredients for their benefits on the impacts of stress are salidroside and rosavin. Salidroside is a glycoside of tyrosol (phenylpropanoid), an active known for its therapeutic activity on stress, cognitive functions and mood improvement through numerous clinical studies. Rosavin is a glycoside of cinnamic alcohol, characteristic of the rosea species, and known for its anxiolytic virtues. A titration in these molecules of interest can be sought to find an effective food supplement formula.

What is an adaptogenic plant? [3]

Rhodiola rosea is characterized as an "adaptogen plant". An "adaptogen" defines pharmacologically active compounds or a plant extract "capable of inducing in an organism a state of increased non-specific resistance, allowing to counterbalance the signals of stress and to adapt to an exceptional effort. Taking adaptogens therefore allows the body to better adapt to stress and maintain its metabolic functions, but also better mental and physical performance. Ginseng (Panax ginseng) is also found in this category.

Stress in brief [4] [5] [6]

Stress is a response to a "stressor" whose intensity depends greatly from one individual to another. There are 2 main types of stress:

• Acute stress: It corresponds to an immediate physical and mental reaction following an unusual, specific and destabilizing event. The symptoms of acute stress can be varied, specific and sudden, such as digestive problems, loss of concentration, agitation, anxiety... Here, stress helps the body to adapt to react as well as possible to stressful stimuli. This is called mobilizing stress. This stress is finely regulated by the secretion of glucocorticoids, mainly represented by cortisol (called "stress hormone"). 
• Chronic stress: It is caused by repeated or continuous stressful stimuli. It can be accompanied by physical and mental exhaustion linked to a constant secretion of stress hormones, to the weakening of our energy reserves and to the increase of calcium on the nerve endings leading to a loss of homeostasis (physiological balance). This stress can cause irritability, anxiety, migraines, insomnia and even depression. Chronic stress affects daily well-being and can lead to physiological disorders if it gets out of control.

It is possible to give our body a boost to help it cope with stress. Nutraceuticals have taken an important place in stress management as the first solution to prevent and manage stress. But when stress becomes chronic, other therapeutic solutions may be necessary.

Rhodiola rosea, stress and clinical studies

This plant has been the subject of much research. On the cerebral sphere, if results show benefits on mental and physical fatigue [7], Rhodiola is especially recognized for its benefits on the management of emotions and anxiety. It is also characterized as the anti-stress plant solution and is used in the formulation of dietary supplements against stress.
This plant can be considered as [5] : 

• a first SOS solution in case of persistent acute stress (not pathological as depression is), 
• a preventive approach to avoid chronic stress. 

Several recent literature reviews highlight the "anti-stress" potential of Rhodiola [5] [8] in food supplements. The oral doses of extracts (of root) most studied correspond on average to a minimum of 12 mg of rosavins and 4 mg of salidrosides per day.

The duration of these clinical studies ranges from 4 to 12 weeks of intake with an increase of positive effects according to the increase of the duration of intake. The analyses carried out from stress/anxiety scores (HAMA score, Hamilton Anxiety Assessment Scale) on subjects with signs of stress and depression have demonstrated the benefits of Rhodiola: a better management of the signs of burn-out (increase in concentration and performance, reduction of fatigue, insomnia...) and an improvement of well-being and quality of life in general. 

How Rhodiola rosea works in detail  

Based on preclinical studies, researchers attribute the neuroprotective effects of Rhodiola rosea to its ability to [9][10][11]:

• Slowing or stopping stress response mediators (cortisol, nitric oxide, glucocorticoid receptor activation)
• Stimulate the release of monoamine neurotransmitters (serotonin and dopamine which can modulate mood and motivation)
• Stimulate the release of opioid peptides (beta-endorphins that can reduce the intensity of the stress response)
• Stimulate the release of neuropeptide Y (which may regulate the hypothalamic-pituitary-adrenal axis and other stress response players)
• Stimulate the synthesis of Brain-Derived Neurotrophic Factor (BDNF), which promotes the survival, growth and plasticity of neurons.

Some studies also suggest that Rhodiola rosea could increase the permeability of the blood-brain barrier, which would contribute to its neuroprotective benefits.

It is for these reasons that it is difficult to separate the benefits of Rhodiola rosea from its central effect of reducing fatigue and stress. Other benefits sometimes cited seem to overlap with these and are rather a consequence. For example, these neuroprotective effects could contribute to the benefits on physical performance: a reduction in the intensity of the stress response could reduce the heart rate during exercise, since physical effort is also a form of stress. An increase in neurotransmitters related to mood and motivation could decrease the perception of fatigue during exercise. Although there is still no global consensus on the mechanisms of fatigue, the key players identified are largely those on which Rhodiola rosea has been observed to act, in particular the hypothalamo-pituitary-adrenal axis.

Why choose our Rhodiola Bio?  

Stress is a process that can very quickly take hold in the body and lead to uncomfortable manifestations. Reacting quickly is therefore key in the management of stress. If nutraceutical solutions can not ensure immediate effects in moments of high intensity stress, they are however recognized for their preventive action. Rhodiola is an adaptogen plant that is found in many preparations of varying quality, whether in formulas based on the plant alone or in a mixture with other active substances. 

The formula of Rhodiola Bio Nutri & Co is the natural solution to help your body to cope with the evils of stress in everyday life.
To develop our formula, we have rigorously focused on : 

• An extract of Rhodiola rosea certified organic: in addition to the cultivation of the plant that meets the criteria of organic farming, the extraction method used to obtain the extract also meets the specifications of the label.
• An extract of Rhodiola rosea standardized in active compounds of interest: with minimum 3% rosavins and minimum 1% salidrosides, measured by HPLC to align with the titration of the extract WS ® 1375 
• A complex of B vitamins also certified organic. Vitamin B6 contributes to normal psychological functions, while B2 contributes to a normal energy metabolism.
• A global formula certified organic. 
  
  

References

1. Panossian, A., Wikman, G., & Sarris, J. (2010). Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine, 17(7), 481–493. doi:10.1016/J.PHYMED.2010.02.002
   
2. Nabavi SF, Braidy N, Orhan IE, Badiee A, Daglia M, Nabavi SM. Rhodiola rosea L. and Alzheimer's Disease: From Farm to Pharmacy. Phytother Res. 2016;30(4):532-539. doi:10.1002/ptr.5569
3. Todorova V, Ivanov K, Delattre C, Nalbantova V, Karcheva-Bahchevanska D, Ivanova S. Plant Adaptogens—History and Future Perspectives. Nutrients. 2021; 13(8):2861. doi:10.3390/nu13082861
4. Do Yup, 2015: Lee DY, Kim E, Choi MH. Technical and clinical aspects of cortisol as a biochemical marker of chronic stress. BMB Rep. 2015;48(4):209-216. doi:10.5483/bmbrep.2015.48.4.275
5. Maares, M.; Haase, H. A Guide to Human Zinc Absorption: General Overview and Recent Advances of In Vitro Intestinal Models. Nutrients 2020, 12, 762, doi:10.3390/nu12030762.
6. Hambidge, M.; Krebs, N.F. Zinc Metabolism and Requirements. Food Nutr. Bull. 2001, 22, 126–132, doi:10.1177/156482650102200202.
7. Roohani, N.; Hurrell, R.; Kelishadi, R.; Schulin, R. Zinc and Its Importance for Human Health: An Integrative Review. J. Res. Med. Sci. 2013, 14.
8. Warthon-Medina, M.; Moran, V.H.; Stammers, A.-L.; Dillon, S.; Qualter, P.; Nissensohn, M.; Serra-Majem, L.; Lowe, N.M. Zinc Intake, Status and Indices of Cognitive Function in Adults and Children: A Systematic Review and Meta-Analysis. Eur. J. Clin. Nutr. 2015, 69, 649–661, doi:10.1038/ejcn.2015.60.
9. Wessels, I.; Maywald, M.; Rink, L. Zinc as a Gatekeeper of Immune Function. Nutrients 2017, 9, 1286, doi:10.3390/nu9121286.
10. Hoffmann, P.R.; Berry, M.J. The Influence of Selenium on Immune Responses. Mol. Nutr. Food Res. 2008, 52, 1273–1280, doi:10.1002/mnfr.200700330.
11. Prasad, A.S.; Mantzoros, C.S.; Beck, F.W.J.; Hess, J.W.; Brewer, G.J. Zinc Status and Serum Testosterone Levels of Healthy Adults. Nutrition 1996, 12, 344–348.

Our promise of transparency also includes the publication of quality analyses:

• Analyse microbiologique