Made in France
Lactose free
Gelatin free
Gluten free
Without excipients
100% vegan certified
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Stress & ToningHigh absorption and high content magnesium
MagShape® Microcapsules combines high content (32% elemental magnesium) and high absorption (higher than bisglycinate)! Thanks to it, each of our capsules contains 100 mg of assimilable elemental magnesium! Magnesium malate and glycerophosphate complete our formula. They use different absorption channels than MagShape®, thus reducing the risk of saturation.More absorption channels means more efficiency!
To be absorbed at the intestinal level and reach the target tissues, most magnesium salts use an ion channel (DMT-1, TRMP6-7), thus creating a "bottleneck" and therefore a loss. In order to reduce a possible risk of "competition" between cations, two of our salts use distinct modes of absorption from DMT 1:- The magnesium liposome, which passes through cell walls thanks to their lipid envelope, like a Trojan horse.
- Glycerophosphate, which as a Chelate uses the DMT 1 channel but also a paracellular.
Digestive comfort
In contrast to molecules such as marine magnesium (oxide and carbonate) or sulphate, which can be considered osmotic laxatives, our carriers do not disturb digestive comfort.The benefits of magnesium are supported by multiple scientific studies.
In addition to playing a central role in the cell division process, this mineral contributes:
- to normal nervous system function,
- to normal psychological functions,
- to normal energy metabolism,
- to the maintenance of normal bone structure,
- to the maintenance of normal dentition,
- to normal protein synthesis,
- to normal muscle function,
- to electrolyte balance,
- and to reduce fatigue.
Vitamin B6 supports magnesium in its action, contributing in particular:
- to normal protein and glycogen metabolism,
- to normal nervous system function,
- to normal psychological functions,
- to normal energy metabolism,
- to reduce fatigue.
When to take Magnesium?
- It is best to space out the Magnesium intake: 1 capsule in the morning, 1 capsule at noon, 1 capsule in the evening, just after a meal for example.
How many capsules?
- Children: 1 to 2 capsules per day (to be opened)*.
- Adolescents: 2 to 3 capsules per day (to be opened)*.
- Adults: 2 to 3 capsules per day.
*Children and teenagers may have difficulty swallowing capsules, so we recommend opening them and pouring the contents into a glass of water, yoghurt or compote.
This product is suitable for pregnant and breastfeeding women.
Stress period: 3 capsules.Duration of one intake
- Magnesium is to be taken in periods of 3 months or over the whole year.
How to take its capsules?
- Simply take with a large glass of water.
Duration of a bottle
- The Magnesium bottle lasts 40 days.
Precautions for use
- Magnesium-based dietary supplement, to be used in addition to a healthy, balanced diet.
- Do not exceed recommended daily doses.
- Pregnant and breastfeeding women should seek the advice of a doctor before supplementing.
Storage conditions
- Store in a dry place away from light and heat.
- Keep out of reach of children.
For 3 capsules Quantity NRV* Magshape® 750 mg - Magnesium Malate 450 mg - GivoMag® (magnesium glycerophosphate) 83 mg - Total magnesium element 300 mg 80%** B6 bio-active 2 mg 143% HPMC vegetable capsules 285 mg -
*NRV: nutritional reference values
**In France, magnesium formulas are limited to 81% of NRVs (300mg/day)Ingredients: Magshape® microcapsules* (corn starch, magnesium oxide, sunflower lecithin), magnesium malate, coating agent: hydroxypropylmethylcellulose, spirulina and apple concentrate, GivoMag® (magnesium glycerophosphate), Vitamin B6 (pyridoxal-5-phosphate).*Magshape is a brand from Lypotec S.A.
What is magnesium?
Magnesium is the 4th most abundant mineral in our body. It is involved in more than 300 enzymatic reactions in humans (lipid, protein and DNA metabolism), which explains its importance. Dietary magnesium is mainly found in cereal bran (whole grains), dried herbs, seeds and oilseeds (the nutritional composition of food can be consulted on the site of ANSES - National Agency for Food, Environmental and Occupational Safety :https://www.anses.fr/fr/content/la-table-de-composition-nutritionnelle-du-ciqual).
About 99% of the body's magnesium is stored in our tissues, and 1% circulates in serum and red blood cells (erythrocytes). Bone tissue contains most of the body's magnesium (50-60%). The rest is stored in skeletal muscle and soft tissue. Since 0.3% of body magnesium is found in serum, serum assays do not reflect magnesium status. Storage (retention), absorption, reabsorption and excretion are the result of exchanges between different body compartments (small intestine, colon, kidney, muscle and bone) from dietary intake of magnesium [1] (see diagram magnesium storage and exchange). For this reason, there is no simple and accurate method of measurement to determine the magnesium status. Nevertheless, the most common measurement is still the measurement of serum concentration, even though it is not very revealing of the status [2]. The erythrocyte assay is more accurate but also more complex and is rather practiced by elite athletes.
(Figure tirée de [3])
For who, for what and why?
The nutritional reference values (NRVs, new name for RDAs: "Recommended Daily Intakes") defined by the EFSA (different from the regulatory values for labelling) depend on the type of population under consideration (NRV table). If there does not seem to be specific NRVs for the elderly, pregnant or breastfeeding women or specific populations such as sportsmen and women, the needs could be increased.[4,5].
Population Age NRV (mg/j) Nourissons 7-11 months 80 Child 1-2 years old 170 Child 3 years old 230 Child 4-9 years old 230 Child 10-17 years old 250 Adults (Women) ≥ 18 ans 300 Adults (Men) ≥ 18 years old 350 Pregnant women ≥ 18 years old 300 Breastfeeding women ≥ 18 years old 300
Optimal magnesium intakes are determined by body requirements, absorption, excretion and retention. For this reason, magnesium deficiencies can be multifactorial [1,6,7] and affect a large part of the population:- Reduction in food choices for "raw" products and more for industrial products (refined products),
- Reduction in absorption due to intestinal disorders, vitamin D deficiency, proton pump inhibiting drugs,
- Gastrointestinal losses resulting from diarrhoea, vomiting, malabsorption, fistulas, Use of laxatives,
- Kidney losses due to alcohol intake, diabetic treatments, hypercalcemia,
- Losses by sweating,
- Genetic manifestations (CCHF type 1 or type 2, Bartter syndrome, Gitelman syndrome...) [8],
- Not covering needs in particular physiological situations (intense stress for example).
Several levels of clinical signs are observable depending on the level of magnetic deficiency. The first signs are characterized by vomiting, facial redness, urinary retention, gastrointestinal disorders, hypotension and muscle pain. Drowsiness, migraines, absence of tendon reflexes, respiratory and especially cardiac disorders (cardiac arrhythmias) may subsequently occur [8]. Beyond the clinical signs, several studies have shown a positive relationship between magnesium and a reduction in moderate to moderate anxiety by acting directly on the stress pathways in our central nervous system. [9].
Mg supplementation makes sense since:
- On the one hand, the intake of magnesium would make it possible to make up the deficits and to ensure the needs to avoid magnesium deficiency, i.e. the moment when the direct manifestations linked to the lack of magnesium become too serious.
This is why magnesium supplementation would be a real preventive asset for intakes increased from 150mg to 400mg.[12].
How?
Magnesium is an ion that needs to be grafted to a carrier to be stabilized and absorbed, i.e., to pass through the intestinal barrier to reach the bloodstream.
And it is within this area that we are touching on the main problem with magnesium supplementation. If magnesium is a major element of choice for the physiological balance of our organism, the selection of the forms in which it must be consumed (when dissociated from food), is essential. In other words, which form of magnesium is to be preferred ?
- The first magnesium salts were in the form of magnesium oxide or marine magnesium (inorganic salts). Although their magnesium content is high (60%), neither absorption nor digestive comfort is optimised [13]. Indeed, these salts often have laxative effects.
- Then come the magnesium salts in which magnesium is chelated (organic salts): bisglycinate, malate, taurinate or citrate, which show a lower magnesium content (on average 12%) compensated by increased absorption and better digestive comfort [14]. In particular, preclinical studies have shown a higher efficacy of magnesium acetyl taurinate in specifically and rapidly reaching cerebral and cognitive nerve tissue [15,16] as well as serum levels of magnesium malate that persisted higher over time [16].
These observations suggest that the combination of the most effective soluble salts (taurinate and malate) and liposomal magnesium (high content and high absorption) seems to be one of the best nutraceutical strategies in the field of magnesium. Moreover, it is important to note that the intake of magnesium is the fractionation dimension of the consumed dose. Indeed, it has been reported that low doses of magnesium are more efficiently absorbed compared to high doses. This is why the European authorities recommend a dose divided by 2 or 3 "portions" ranging from 80 to 100mg per dose [18].
Additional magnesium ?
As a reminder, magnesium is involved in more than 300 enzymatic reactions in the human body. Indeed, several major roles characterize magnesium: role of co-factor, role in active transport, structural role, role in immunological functions [3,8]. Due to its affinity with phosphate, magnesium (in its ionized form) plays a role in the phosphorylation of ATP and thus in energy metabolism. At the muscular level, magnesium is a co-factor of phosphocreatine, essential for the resynthesis of ATP (an intermediate energy molecule). This role as a co-factor in the muscle gives magnesium a primordial action in muscle contraction because this phenomenon is known as "ATP-dependent". But more broadly, magnesium as a co-factor is essential to the process of protein synthesis, muscle nerve transmission, neuromuscular conduction and carbohydrate homeostasis. Magnesium as a transporter facilitates the transport of calcium and potassium across cell membranes, which is especially important for nerve conduction, muscle contraction and regulation of cardiac function. Magnesium is also involved in the structure of many physiological components of our body: bones, proteins, a large number of enzymes, mitochondria, DNA and RNA. Finally, it is important in immunological functions, including macrophage activation, cell adhesion, bactericidal activity, lymphocyte proliferation and the binding of endotoxins to monocytes. In conclusion, magnesium is everywhere. It is therefore through all its major physiological implications that magnesium is also associated with a reduced risk of certain cardio-metabolic pathologies. Low serum magnesium levels are linked to a greater prevalence of metabolic syndrome, type II diabetes, hypertension and atherosclerosis [19,20].
Publications
- Ahmed, F.; Mohammed, A. Magnesium: The Forgotten Electrolyte—A Review on Hypomagnesemia. Med. Sci. 2019, 7, 56.
- Jahnen-Dechent, W.; Ketteler, M. Magnesium basics. Clin. Kidney J. 2012, 5, i3–i14.
- de Baaij, J.H.F.; Hoenderop, J.G.J.; Bindels, R.J.M. Magnesium in Man: Implications for Health and Disease. Physiol. Rev. 2015, 95, 1–46.
- Swaminathan, R. Magnesium Metabolism and its Disorders. Clin Biochem Rev 2003, 24, 20.
- Laires, M.J. Role of cellular magnesium in health and human disease. Front. Biosci. 2004, 9, 262.
- Elin, R.J. Assessment of magnesium status for diagnosis and therapy. 2016, 5.
- Schwalfenberg, G.K.; Genuis, S.J. The Importance of Magnesium in Clinical Healthcare. Scientifica 2017, 2017, 1–14.
- Al Alawi, A.M.; Majoni, S.W.; Falhammar, H. Magnesium and Human Health: Perspectives and Research Directions. Int. J. Endocrinol. 2018, 2018, 1–17.
- Neil Boyle; Clare Lawton; Louise Dye The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review. Nutrients 2017, 9, 429.
- Vormann, J. Magnesium: nutrition and metabolism. Mol. Aspects Med. 2003, 24, 27–37.
- DiNicolantonio, J.J.; O’Keefe, J.H.; Wilson, W. Subclinical magnesium deficiency: a principal driver of cardiovascular disease and a public health crisis. Open Heart 2018, 5, e000668.
- Razzaque, M. Magnesium: Are We Consuming Enough? Nutrients 2018, 10, 1863.
- Blancquaert, L.; Vervaet, C.; Derave, W. Predicting and Testing Bioavailability of Magnesium Supplements. Nutrients 2019, 11, 1663.
- Kappeler, D.; Heimbeck, I.; Herpich, C.; Naue, N.; Höfler, J.; Timmer, W.; Michalke, B. Higher bioavailability of magnesium citrate as compared to magnesium oxide shown by evaluation of urinary excretion and serum levels after single-dose administration in a randomized cross-over study. BMC Nutr. 2017, 3, 7.
- Lambuk, L.; Jafri, A.J.A.; Arfuzir, N.N.N.; Iezhitsa, I.; Agarwal, R.; Rozali, K.N.B.; Agarwal, P.; Bakar, N.S.; Kutty, M.K.; Yusof, A.P.Md.; et al. Neuroprotective Effect of Magnesium Acetyltaurate Against NMDA-Induced Excitotoxicity in Rat Retina. Neurotox. Res. 2017, 31, 31–45.
- Uysal, N.; Kizildag, S.; Yuce, Z.; Guvendi, G.; Kandis, S.; Koc, B.; Karakilic, A.; Camsari, U.M.; Ates, M. Timeline (Bioavailability) of Magnesium Compounds in Hours: Which Magnesium Compound Works Best? Biol. Trace Elem. Res. 2019, 187, 128–136.
- Brilli, E.; Khadge, S.; Fabiano, A.; Zambito, Y.; Williams, T.; Tarantino, G. Biovailability of Sucrosomial® magnesium vs. standard formulations. Eur Rev Med Pharmacol Sci 2018, 22, 1843–1851.
- Siebrecht, S. Magnesium Bisglycinate as safe form for mineral supplementation in human nutrition. Sonderdruck 2013, 144, 16.
- Chacko, S.A.; Sul, J.; Song, Y.; Li, X.; LeBlanc, J.; You, Y.; Butch, A.; Liu, S. Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. Am. J. Clin. Nutr. 2011, 93, 463–473.
- Geiger, H.; Wanner, C. Magnesium in disease. Clin. Kidney J. 2012, 5, i25–i38.
Aquestion ?
Our experts answer all yourquestions.Why does magnesium need a transporter?
Magnesium is an ion (Mg2+) that needs to be grafted to another molecule in order to be stabilised and passed from the intestine into the blood plasma. It is this molecule that is called a transporter and there are several types. Discover for that our infographic on magnesium.
What about marine magnesium?
It's true that the name marine magnesium has a lot to offer. However, this product hides a less than stellar reality since it is composed of more than 80% magnesium oxide, a carrier known for its very low absorption (4%). Marketing to encourage people to buy? To find out more, you can take a look at our article Magnesium-marine: diving in troubled waters...
Is there a risk of excess magnesium?
Since excess magnesium is easily eliminated by the kidneys, the risk of excess is rare. The few cases that have been observed have been associated with severe kidney failure. People suffering from this type of problem should seek advice from their doctor.
Why not taurine with your magnesium?
Taurine is sometimes combined with magnesium and potassium supplements because it is believed to improve their penetration into the cells. It is also sometimes associated with these two micronutrients for its effects on performance and endurance. However, the doses used in this case are significant (1-6g per day), and the sources of magnesium that we have chosen are sufficiently well absorbed to do without a co-factor such as taurine. With 3 capsules per day for 300 mg of elemental magnesium, you have everything you need to fill up on magnesium!
What is the duration of a cure?
A course of treatment generally lasts 2 to 3 months, the time it takes to replenish your magnesium stock (about 25 grams). However, sportsmen and women, pregnant women and the elderly can supplement continuously because of their increased needs.
Is your magnesium natural?
In our view, the debate between natural and synthetic is a mistake. The real question is whether an ingredient is bio-identical or not, i.e. whether it has a form identical to that found in our food.
If magnesium is found naturally in sea salt in the form of an oxide, we know that this carrier is not identical to conventional food forms. The result? This form is poorly absorbed and often causes digestive problems.
We therefore prefer bioidentical forms of magnesium, i.e. whose carrier is recognised as a nutrient by the body:
- malic acid found in apples,
- glycerophosphate, itself composed of glycerol and phosphate, two molecules naturally present in the body,
- or natural microcapsules, composed of corn starch and sunflower lecithin.
Is magnesium useful for athletes?
Sportsmen and women have a higher than average consumption of magnesium and must therefore replenish their stock regularly. This mineral is involved in the production of ATP (muscle energy), the reduction of cramps and protein synthesis. While a balanced diet allows for an honest daily intake, we can only recommend supplementation to ensure that the RA* is achieved.
*Reference Intake
Will I have digestive problems with your magnesium?
In principle, no. We have selected 3 types that are particularly well tolerated and do not cause digestive problems. Marine magnesium or oxide salts cause digestive problems because of their osmotic activity: they capture water and disturb digestion. Malate and glycerophosphate salts, as well as liposomal magnesium, are not osmotic at all and therefore in principle do not cause any digestive disorders.
Do your blue capsules use a chemical dye?
No, our capsules do not contain any chemical or synthetic dyes. What gives them their beautiful blue colour is a natural phyto-pigment extracted from the spirulina algae: the famous phycocyanine.
Where do our ingredients comefrom?
Bioactive Vitamin B6 - DSMScotland
B6 accompanies magnesium in all its chemical reactions.
Givomag® - Magnesium Glycerophosphate - IsaltisLyon, France
Isaltis is a French company specialising in the production and study of highly bioavailable minerals.
Vegetable capsule - LonzaStrasbourg, France
Considered the highest quality capsule manufacturer in the world.
Magshape® Microcapsules - Magnesium Liposome - LypotecBarcelona, Spain
Lypotec is an international group based in Barcelona and specialising in liposomal forms of minerals for the cosmetics and nutraceutical industries.
Encapsulation - Lustrel LaboratoryOccitania, France
A reference in nutraceutical shaping, ISO 22000 and Organic certified.
Magnesium Malate - Jost ChemicalMissouri, USA
Molecule known for its high assimilation and high digestive tolerance.
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