Cranberry
Cranberry

Elimination • Urinary comfort

20 sticks • 2/day

Quantity :
Add to cart - €26.90
Cranberry

Elimination • Urinary comfort

20 sticks • 2/day

1 in 2 women will experience one or more episodes of urinary discomfort during her lifetime. Beyond the medical solutions sent, Nutraceuticals offers natural and effective answers.

Our formula with respected clinical dosage offers an unprecedented combination of 4 benchmark active ingredients. They are associated with a natural cherry aroma and come in the form of practical and discreet sticks.

€26.90
Quantity :


Add to cart - €26.90

*Valid on all product combinations - Does not apply to packs

EFFECTIVENESS

Confort Urinaire Elimination Urinary comfort & Elimination

Practicality and discretion above all!

Efficiency is good, but without practicality, is it really useful ? This is why our scientific team has made a point of offering an effective formula that is simple and pleasant to use. In the form of a 100% natural cherry flavored powder with no added sugars, our Cranberry Mannose has been designed to be diluted in water, and thus promote water intake, which is essential during urinary discomfort! Discreet to transport, its 2 daily sticks ensure high dosages of active ingredients that capsules or tablets would not have allowed.

A high dosage without compromise

Because we aim for efficiency above all, the choices and the dosages of the ingredients of our Cranberry Mannose have been established on the basis of scientific literature: with 2 sticks per day, our formula provides 4 g of D-mannose, 240 mg of a cranberry extract standardized with 36 mg of proanthocyanidins (PACs), as well as a hibiscus extract and a pomegranate extract, each dosed at 200 mg. Our formula is thus the first to combine not 1 nor 2 but indeed 4 effective and above all correctly dosed active ingredients!

4 100% natural active ingredients

In addition to cranberry extract and our fermented D-mannose, our formula capitalizes on the complementary effectiveness of two patented plant extracts:

  • Ellirose ™: an extract of hibiscus flower, particularly rich in hibiscus and whose bioavailability has been clinically demonstrated
  • Pomanox®: a pomegranate extract particularly rich in ellagic acid (8%), a recognized polyphenol.

Everything is without added sugars, sweeteners or additives.

BENEFITS

Cranberry Mannose is a combination of D-mannose, a cranberry / cranberry extract rich in proanthocyanidins (PACs) and two additional plant extracts (hibiscus and pomegranate) developed to specifically target urinary tract function.

Hibiscus is used to aid the body's drainage functions. It stimulates the elimination function of the body and contributes to the functioning of the urinary tract.

HOW TO USE IT

When to take our Cranberry Mannose ?

  • Our Cranberry Mannose should be taken in the morning for breakfast and in the evening with dinner.

How many sticks ?

  • Children: not recommended.
  • Adolescents: (from 14 years old) 2 sticks (2 x 6 g) per day.
  • Adults: 2 sticks (2 x 6 g) per day.a

Duration of a dose

  • Our Cranberry Mannose is taken over a period of 10 days.

How to take our Cranberry Mannose ?

  • Dilute the contents of one stick (6 g) in a large glass of water (200ml), mix until completely dissolved.

Duration of a box

  • La boîte de notre Cranberry Mannose dure 10 jours, à raison de 2 sticks par jour.

Precautions of use

  • Food supplement based on cranberry (cranberry), d-mannose, hibiscus and pomegranate, to be used in addition to a healthy and balanced diet.
  • Do not exceed the daily doses indicated.
  • Pregnant or breastfeeding women should seek medical advice before any supplementation.

Storage conditions

  • Store in a dry place away from heat and light.
  • Keep out of the reach of children.

INGREDIENTS

Nutritional value (mg) for 2 sticks (12 g)

D-mannose : 4000

Cranberry fruit extract (Urophenol®): 240
  of which proanthocyanidins (PACs) : 36

Hibiscus flower extract (Ellirose™) : 200
  of which phenolic : 90

Pomegranate fruit extract (Pomanox®): 200
  including punicalagins : 60
  of which ellagic acid : 16

Ginselect™ (ginseng extract) : 200
  of which ginsenosides (7%) : 14

Cranberry juice powder : 1000

Ingredients: Passion fruit juice powder (Passiflora edulis S); D-mannose, Cranberry juice powder (Vaccinium macrocarpon Aiton); Urophenol® [extract of whole cranberries concentrated in proanthocyanidins (Vaccinium macrocarpon Aiton)]; Ellirose ™ [hibiscus flower extract (Hibiscus sabdariffa L)]; Pomanox® [pomegranate fruit extract (PunicagranatumL)]; Natural flavors: cherry.

SCIENCE

Urinary discomfort vs cystitis [1]

By “urinary discomfort” is meant any infection of the urinary system without complication, manifesting in healthy individuals and without associated additional sensitivity factor. Discomfort or urinary tract infection most commonly results from bacterial infections, and mainly affects adults.

Cystitis is a urinary tract infection giving rise to inflammation precisely localized in the bladder. While it can cause significant discomfort, it is usually not serious and its symptoms are characteristic: a burning sensation, low urine volume (pollakiuria) and recurrence of the urge to urinate. It is important to treat it quickly before it goes to the kidneys, making the symptoms more acute, and possibly causing fever and back pain. For this, various treatments with proven effectiveness exist.

We essentially identify 2 types of cystitis:

  • simple acute cystitis (without additional sensitivity factor),
  • acute cystitis at risk of complications, which include at least one factor of sensitivity (such as pregnancy or menopause in women, or even diabetes).

Simple acute cystitis can be referred to as acute relapsing cystitis when a person experiences at least 3-4 episodes in a year. To limit such recurrences, it is important to ensure good prevention and to understand to whom this public health concern is addressed.

Origin of urinary discomfort [1–3]

The urinary system is made up of our two kidneys connected to the bladder by two ureters. The bladder is also connected to the urethra, which is the outlet for urine.

Appareils urinaires féminin et masculin

This system naturally has defense mechanisms against the invasion of pathogens, and therefore against infections.

In more than 70% of cases, urinary discomfort results from a bacterial infection by a specific community: Enterobacteriaceae, and more particularly Escherichia coli (E. coli). This bacteria naturally present in the digestive tract (colon, rectum) can enter the urethra, then rise up into the bladder and adhere to the walls of the bladder causing inflammation and symptoms associated with a urinary tract infection.

An essentially feminine manifestation [3,4]

It is the anatomical differences between men and women that make women more prone to UTIs. From an anatomical point of view, the urethra of women is shorter than that of men (see diagram), but also closer to the vagina and rectum, places of natural presence of bacteria. Other factors: sex and pregnancy can also promote urinary tract infections and cystitis. The frequency of cystitis is important in women, and particularly in women of childbearing age. It is estimated that 50 to 60% of women (at least 1 in 2 women!) Contract some manifestation of urinary discomfort during their lifetime, and about 40% develop a second one within a year of the first. Some women are even prone to recurrent cystitis (3 to 4 repeats per year). Two frequency peaks are generally observed: at the start of sexual activity and after menopause with the drop in estrogen.

Solutions and associated issues

To resolve cystitis, antibiotic treatments remain to this day the most effective means from a therapeutic point of view. But faced with the emergence of antibiotic resistance [5] and the potential effect of antibiotics on the microbiota, alternative approaches are increasingly being studied [6,7] to limit recurrence without resorting to antibiotics, such as:

  • Reduce the frequency of the use of antibiotics,
  • Veiller à maintenir une  flore bactérienne saine pour préserver des défenses efficaces contre les pathogènes.

There are good practices published by the Haute Autorité de Santé (HAS) related to the management of cystitis [8] aimed at specifying the appropriate antibiotic treatments according to the levels of intention.

Today, non-drug prophylactic (prevention) methods for the fight against cystitis are well referenced and documented by the scientific community.

What the Research says about natural prevention alternatives

The problem of urinary discomfort in women represents such a cost to public health that the study of alternatives to prevent recurrence was initiated several years ago. At the same time, urology organizations are also working to promote potential solutions through active research on certain ingredients. Among the most cited in reference, we find cranberry (or cranberry, in French) and D-mannose [9–12]:

Cranberry
The cranberry (Vaccinium macrocarpon), also called `` american cranberry '', great lingonberry, or cranberry, is a berry particularly known for its many health benefits thanks to its content of polyphenols, in particular of the class of proanthocyanidins of the type A (category flavan-3-ols). Proanthocyanidins carry the acronym of PACs (a reference indication put forward on nutraceuticals). Among its interesting properties, cranberries may interfere with the adhesion of bacteria, acting locally in the urine [13,14]. In 2014, a clinical analysis of taking cranberry extract established the effectiveness of a standard daily dose of 36 mg of PACs [15]. A more recent meta-analysis also made it possible to conclude positively on the relevance of cranberry [16]. This compilation work highlights an important point on the perfect tolerance of the daily intake of extract standardized to 36 mg of PACs. It is important to note that the principle of standardization only applies to specific extracts, and does not apply to other types of preparations such as cranberry juice. Finally, validating the exact PAC concentration of an extract requires a reference methodology validated and institutionalized by major regulatory authorities: this is the method called BL-DMAC [17].

D-mannose  [18–20]
D-Mannose is a monosaccharide, a sugar, naturally present in the body. It is also found in our diet, especially in fruits such as cranberries. Although D-mannose is a simple sugar (like glucose), however, it is not metabolized by the body. Indeed, pharmacokinetic data on the ingestion of D-mannose has shown that at least 90% of this sugar is absorbed and reaches the bloodstream and ends up intact in the urine. Its urinary excretion is linked to its local mechanistic effects: by binding to certain pathogens such as E.coli, D-mannose would limit its adhesion to the mucosa. The compilation of clinical studies also proves the very good tolerance and efficacy of D-mannose in the form of a daily oral intake of 2 g and more.

Nutri&Co's choice

Like all of our formulas, this is of course the effectiveness that we aim for with our Cranberry Mannose formula. To effectively combat urinary discomfort, we have opted for a combination of 4 judiciously developed active ingredients:

  1. High dosages without concession in reference ingredients:
    • The patented cranberry / cranberry extract, Urophenol®, is highly specific thanks to its polyphenol profile (use of whole cranberry fruit) and the variety from which it is derived. It is supported by its own clinical study [21] based on a unique and original protocol [22], comparing the efficacy of the extract at 36 mg of PACs versus an extract with very low PACS content (2 mg). This extract therefore goes further than a simple cranberry juice low in PACs: a total of 240 mg of an extract standardized to 36 mg of PACs and analyzed according to the official BL-DMAC method that we have put in our formula,
    • Another proven ingredient: D-mannose, which we have chosen to dose at 4 g daily, which is double the smallest dose with clinically proven effectiveness. Thus, 1 single daily stick already provides the minimum effective dose of D-mannose of 2 g.
  2. 2 other extracts with additional benefits :
    • An extract of hibiscus flower (Hibiscus sadbariffa): the ElliroseTM extract which presents, thanks to its patented extraction process, a particular profile in organic acids (> 40%) and polyphenols (> 45%), including 'swimming pool, and known for their antimicrobial activity. In preliminary studies, analysis of the bioavailability of ElliroseTM has shown that its compounds are found intact in the urine. More recently, a clinical study was conducted on 40 women with recurrent urinary tract infections treated with 200 mg of ElliroseTM per day. The results showed that after 3 months of use, the women not only exhibited very good tolerance to the extract, but above all an improvement in the functioning of the urinary tract [23], and therefore restored urinary comfort.
    • Pomegranate extract (Punica granatum): the selected pomegranate fruit extract, Pomanox®, is patented and standardized in punicalagins (> 30%), including ellagitannins with ellagic acid. Ellagic acid is known to be metabolized in the body by the microbiota to form urolithins A and B. At the urinary level, the pomegranate seems interesting for its antibacterial activity [24–27].
  3. A format designed for optimal efficiency :
    • A powder formula to be diluted which encourages and promotes water intake: the first hygienic and dietary rule to apply in the event of urinary discomfort.
    • Sticks that are easy and practical to use and transport on a daily basis and which allow us a formula with a high dosage of active ingredients (which would have been impossible in the form of capsules).
    • A natural cherry flavoring to make it easier to set, and last until the end of 10 days.
    • The entire effective dose in 1 single box: 20 sticks for 10 days of intake (2 stickers per day).

Publications

  1. Wagenlehner, F.M.E.; Bjerklund Johansen, T.E.; Cai, T.; Koves, B.; Kranz, J.; Pilatz, A.; Tandogdu, Z. Epidemiology, Definition and Treatment of Complicated Urinary Tract Infections. Nat. Rev. Urol. 2020, 17, 586–600, doi:10.1038/s41585-020-0362-4.
  2. Flores-Mireles, A.L.; Walker, J.N.; Caparon, M.; Hultgren, S.J. Urinary Tract Infections: Epidemiology, Mechanisms of Infection and Treatment Options. Nat. Rev. Microbiol. 2015, 13, 269–284, doi:10.1038/nrmicro3432.
  3. Medina, M.; Castillo-Pino, E. An Introduction to the Epidemiology and Burden of Urinary Tract Infections. Ther. Adv. Urol. 2019, 11, 175628721983217, doi:10.1177/1756287219832172.
  4. Foxman, B.; Barlow, R.; D’Arcy, H.; Gillespie, B.; Sobel, J.D. Urinary Tract Infection: Self-Reported Incidence and Associated Costs. 2000, 10, 7.
  5. Zowawi, H.M.; Harris, P.N.A.; Roberts, M.J.; Tambyah, P.A.; Schembri, M.A.; Pezzani, M.D.; Williamson, D.A.; Paterson, D.L. The Emerging Threat of Multidrug-Resistant Gram-Negative Bacteria in Urology. Nat. Rev. Urol. 2015, 12, 570–584, doi:10.1038/nrurol.2015.199.
  6. Colgan, R.; Williams, M. Diagnosis and Treatment of Acute Uncomplicated Cystitis. 2011, 84, 6.
  7. Foxman, B.; Buxton, M. Alternative Approaches to Conventional Treatment of Acute Uncomplicated Urinary Tract Infection in Women. Curr. Infect. Dis. Rep. 2013, 15, 124–129, doi:10.1007/s11908-013-0317-5.
  8. HAS Cystite Aiguë Simple, à Risque de Complication Ou Récidivante, de La Femme Available online: https://www.has-sante.fr/jcms/c_2722827/fr/cystite-aigue-simple-a-risque-de-complication-ou-recidivante-de-la-femme.
  9. AFU CYSTITES RÉCIDIVANTES : DES MOYENS DE PRÉVENTION NON MÉDICAMENTEUX Available online: https://www.urofrance.org/base-bibliographique/cystites-recidivantes-des-moyens-de-prevention-non-medicamenteux.
  10. Costantini, E.; Giannitsas, K.; Illiano, E. The Role of Nonantibiotic Treatment of Community-Acquired Urinary Tract Infections. Curr. Opin. Urol. 2017, 27, 120–126, doi:10.1097/MOU.0000000000000366.
  11. Cai, T.; Tamanini, I.; Kulchavenya, E.; Perepanova, T.; Köves, B.; Wagenlehner, F.M.E.; Tandogdu, Z.; Bonkat, G.; Bartoletti, R.; Bjerklund Johansen, T.E. The Role of Nutraceuticals and Phytotherapy in the Management of Urinary Tract Infections: What We Need to Know? Arch. Ital. Urol. E Androl. 2017, 89, 1, doi:10.4081/aiua.2017.1.1.
  12. Loubet, P.; Ranfaing, J.; Dinh, A.; Dunyach-Remy, C.; Bernard, L.; Bruyère, F.; Lavigne, J.-P.; Sotto, A. Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections. Front. Microbiol. 2020, 11, 1509, doi:10.3389/fmicb.2020.01509.
  13. Blumberg, J.B.; Camesano, T.A.; Cassidy, A.; Kris-Etherton, P.; Howell, A.; Manach, C.; Ostertag, L.M.; Sies, H.; Skulas-Ray, A.; Vita, J.A. Cranberries and Their Bioactive Constituents in Human Health. Adv. Nutr. 2013, 4, 618–632, doi:10.3945/an.113.004473.
  14. González de Llano, D.; Liu, H.; Khoo, C.; Moreno-Arribas, M.V.; Bartolomé, B. Some New Findings Regarding the Antiadhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Bacteria. J. Agric. Food Chem. 2019, 67, 2166–2174, doi:10.1021/acs.jafc.8b05625.
  15. Jepson, R.G.; Williams, G.; Craig, J.C. Cranberries for Preventing Urinary Tract Infections. Cochrane Database Syst. Rev. 2012, doi:10.1002/14651858.CD001321.pub5.
  16. Fu, Z.; Liska, D.; Talan, D.; Chung, M. Cranberry Reduces the Risk of Urinary Tract Infection Recurrence in Otherwise Healthy Women: A Systematic Review and Meta-Analysis. J. Nutr. 2017, 147, 2282–2288, doi:10.3945/jn.117.254961.
  17. Haesaerts, G. Le dosage des proanthocyanidines (PAC) de cranberry dans les compléments alimentaires: enjeux et derniers développements. Phytothérapie 2010, 8, 218–222, doi:10.1007/s10298-010-0575-4.
  18. Altarac, S.; Papeš, D. Use of D-Mannose in Prophylaxis of Recurrent Urinary Tract Infections (UTIs) in Women: Comment. BJU Int. 2014, 113, 9–10, doi:10.1111/bju.12492.
  19. De Nunzio, C.; Bartoletti, R.; Tubaro, A.; Simonato, A.; Ficarra, V. Role of D-Mannose in the Prevention of Recurrent Uncomplicated Cystitis: State of the Art and Future Perspectives. Antibiotics 2021, 10, 10.
  20. Scaglione, F.; Musazzi, U.M.; Minghetti, P. Considerations on D-Mannose Mechanism of Action and Consequent Classification of Marketed Healthcare Products. Front. Pharmacol. 2021, 12, 636377, doi:10.3389/fphar.2021.636377.
  21. Babar, A.; Moore, L.; Leblanc, V.; Dudonné, S.; Desjardins, Y.; Lemieux, S.; Bochard, V.; Guyonnet, D.; Dodin, S. High Dose versus Low Dose Standardized Cranberry Proanthocyanidin Extract for the Prevention of Recurrent Urinary Tract Infection in Healthy Women: A Double-Blind Randomized Controlled Trial. BMC Urol. 2021, 21, 44, doi:10.1186/s12894-021-00811-w.
  22. Asma, B.; Vicky, L.; Stephanie, D.; Yves, D.; Amy, H.; Sylvie, D. Standardised High Dose versus Low Dose Cranberry Proanthocyanidin Extracts for the Prevention of Recurrent Urinary Tract Infection in Healthy Women [PACCANN]: A Double Blind Randomised Controlled Trial Protocol. BMC Urol. 2018, 18, 29, doi:10.1186/s12894-018-0342-7.
  23. Allaert, F.A. Prevention of Recurrent Cystitis in Women: Double-Blind, Placebo- Controlled Study of Hibiscus Sabdariffa L. Extract. Lett. L’Infectiologue 2010, 5.
  24. Espín, J.C.; González-Barrio, R.; Cerdá, B.; López-Bote, C.; Rey, A.I.; Tomás-Barberán, F.A. Iberian Pig as a Model To Clarify Obscure Points in the Bioavailability and Metabolism of Ellagitannins in Humans. J. Agric. Food Chem. 2007, 55, 10476–10485, doi:10.1021/jf0723864.
  25. Howell, A.B.; D’Souza, D.H. The Pomegranate: Effects on Bacteria and Viruses That Influence Human Health. Evid. Based Complement. Alternat. Med. 2013, 2013, 1–11, doi:10.1155/2013/606212.
  26. Zam, W.; Khaddour, A. Anti-Virulence Effects of Aqueous Pomegranate Peel Extract on E. Coli Urinary Tract Infection. Prog. Nutr. 2017, 19, doi:10.23751/pn.v19i1-S.5693.
  27. Ammar, O.M.A.; Ilktac, M.; Gulcan, H.O. Urolithins and Their Antimicrobial Activity: A Short Review. EMUJPharmSci 2020, 8.
EFFECTIVENESS
BENEFITS
HOW TO USE IT
INGREDIENTS
SCIENCE
Confort Urinaire Elimination Urinary comfort & Elimination

Practicality and discretion above all!
Efficiency is good, but without practicality, is it really useful ? This is why our scientific team has made a point of offering an effective formula that is simple and pleasant to use. In the form of a 100% natural cherry flavored powder with no added sugars, our Cranberry Mannose has been designed to be diluted in water, and thus promote water intake, which is essential during urinary discomfort! Discreet to transport, its 2 daily sticks ensure high dosages of active ingredients that capsules or tablets would not have allowed.

A high dosage without compromise
Because we aim for efficiency above all, the choices and the dosages of the ingredients of our Cranberry Mannose have been established on the basis of scientific literature: with 2 sticks per day, our formula provides 4 g of D-mannose, 240 mg of a cranberry extract standardized with 36 mg of proanthocyanidins (PACs), as well as a hibiscus extract and a pomegranate extract, each dosed at 200 mg. Our formula is thus the first to combine not 1 nor 2 but indeed 4 effective and above all correctly dosed active ingredients!

4 100% natural active ingredients
In addition to cranberry extract and our fermented D-mannose, our formula capitalizes on the complementary effectiveness of two patented plant extracts:

  • Ellirose ™: an extract of hibiscus flower, particularly rich in hibiscus and whose bioavailability has been clinically demonstrated
  • Pomanox®: a pomegranate extract particularly rich in ellagic acid (8%), a recognized polyphenol.

Everything is without added sugars, sweeteners or additives.

Cranberry Mannose is a combination of D-mannose, a cranberry / cranberry extract rich in proanthocyanidins (PACs) and two additional plant extracts (hibiscus and pomegranate) developed to specifically target urinary tract function.

Hibiscus is used to aid the body's drainage functions. It stimulates the elimination function of the body and contributes to the functioning of the urinary tract.

When to take our Cranberry Mannose ?

  • Our Cranberry Mannose should be taken in the morning for breakfast and in the evening with dinner.

How many sticks ?

  • Children: not recommended.
  • Adolescents: (from 14 years old) 2 sticks (2 x 6 g) per day.
  • Adults: 2 sticks (2 x 6 g) per day.a

Duration of a dose

  • Our Cranberry Mannose is taken over a period of 10 days.

How to take our Cranberry Mannose ?

  • Dilute the contents of one stick (6 g) in a large glass of water (200ml), mix until completely dissolved.

Duration of a box

  • La boîte de notre Cranberry Mannose dure 10 jours, à raison de 2 sticks par jour.

Precautions of use

  • Food supplement based on cranberry (cranberry), d-mannose, hibiscus and pomegranate, to be used in addition to a healthy and balanced diet.
  • Do not exceed the daily doses indicated.
  • Pregnant or breastfeeding women should seek medical advice before any supplementation.

Storage conditions

  • Store in a dry place away from heat and light.
  • Keep out of the reach of children.
Ingrédients (mg)
For 6 g = 1 stickFor 12 g = 2 sticks
D-mannose20004000
Cranberry fruit extract (Urophenol®)120240
of which proanthocyanidins (PACs)1836
Hibiscus flower extract (ElliroseTM)100200
of which phenolics4590
Pomegranate fruit extract (Pomanox®)100200
of which punicalagins3060
of which ellagic acid816
Cranberry juice powder5001000

Ingredients: Passion fruit juice powder (Passiflora edulis S); D-mannose, Cranberry juice powder (Vaccinium macrocarpon Aiton); Urophenol® [extract of whole cranberries concentrated in proanthocyanidins (Vaccinium macrocarpon Aiton)]; Ellirose ™ [hibiscus flower extract (Hibiscus sabdariffa L)]; Pomanox® [pomegranate fruit extract (PunicagranatumL)]; Natural flavors: cherry.

Urinary discomfort vs cystitis [1]
By “urinary discomfort” is meant any infection of the urinary system without complication, manifesting in healthy individuals and without associated additional sensitivity factor. Discomfort or urinary tract infection most commonly results from bacterial infections, and mainly affects adults.

Cystitis is a urinary tract infection giving rise to inflammation precisely localized in the bladder. While it can cause significant discomfort, it is usually not serious and its symptoms are characteristic: a burning sensation, low urine volume (pollakiuria) and recurrence of the urge to urinate. It is important to treat it quickly before it goes to the kidneys, making the symptoms more acute, and possibly causing fever and back pain. For this, various treatments with proven effectiveness exist.

We essentially identify 2 types of cystitis:

  • simple acute cystitis (without additional sensitivity factor),
  • acute cystitis at risk of complications, which include at least one factor of sensitivity (such as pregnancy or menopause in women, or even diabetes).

Simple acute cystitis can be referred to as acute relapsing cystitis when a person experiences at least 3-4 episodes in a year. To limit such recurrences, it is important to ensure good prevention and to understand to whom this public health concern is addressed.

Origin of urinary discomfort [1–3]
The urinary system is made up of our two kidneys connected to the bladder by two ureters. The bladder is also connected to the urethra, which is the outlet for urine.

Appareils urinaires féminin et masculin

This system naturally has defense mechanisms against the invasion of pathogens, and therefore against infections.

In more than 70% of cases, urinary discomfort results from a bacterial infection by a specific community: Enterobacteriaceae, and more particularly Escherichia coli (E. coli). This bacteria naturally present in the digestive tract (colon, rectum) can enter the urethra, then rise up into the bladder and adhere to the walls of the bladder causing inflammation and symptoms associated with a urinary tract infection.

An essentially feminine manifestation [3,4]
It is the anatomical differences between men and women that make women more prone to UTIs. From an anatomical point of view, the urethra of women is shorter than that of men (see diagram), but also closer to the vagina and rectum, places of natural presence of bacteria. Other factors: sex and pregnancy can also promote urinary tract infections and cystitis. The frequency of cystitis is important in women, and particularly in women of childbearing age. It is estimated that 50 to 60% of women (at least 1 in 2 women!) Contract some manifestation of urinary discomfort during their lifetime, and about 40% develop a second one within a year of the first. Some women are even prone to recurrent cystitis (3 to 4 repeats per year). Two frequency peaks are generally observed: at the start of sexual activity and after menopause with the drop in estrogen.

Solutions and associated issues
To resolve cystitis, antibiotic treatments remain to this day the most effective means from a therapeutic point of view. But faced with the emergence of antibiotic resistance [5] and the potential effect of antibiotics on the microbiota, alternative approaches are increasingly being studied [6,7] to limit recurrence without resorting to antibiotics, such as:

  • Reduce the frequency of the use of antibiotics,
  • Veiller à maintenir une  flore bactérienne saine pour préserver des défenses efficaces contre les pathogènes.

There are good practices published by the Haute Autorité de Santé (HAS) related to the management of cystitis [8] aimed at specifying the appropriate antibiotic treatments according to the levels of intention.

Today, non-drug prophylactic (prevention) methods for the fight against cystitis are well referenced and documented by the scientific community.

What the Research says about natural prevention alternatives
The problem of urinary discomfort in women represents such a cost to public health that the study of alternatives to prevent recurrence was initiated several years ago. At the same time, urology organizations are also working to promote potential solutions through active research on certain ingredients. Among the most cited in reference, we find cranberry (or cranberry, in French) and D-mannose [9–12]:

Cranberry
The cranberry (Vaccinium macrocarpon), also called `` american cranberry '', great lingonberry, or cranberry, is a berry particularly known for its many health benefits thanks to its content of polyphenols, in particular of the class of proanthocyanidins of the type A (category flavan-3-ols). Proanthocyanidins carry the acronym of PACs (a reference indication put forward on nutraceuticals). Among its interesting properties, cranberries may interfere with the adhesion of bacteria, acting locally in the urine [13,14]. In 2014, a clinical analysis of taking cranberry extract established the effectiveness of a standard daily dose of 36 mg of PACs [15]. A more recent meta-analysis also made it possible to conclude positively on the relevance of cranberry [16]. This compilation work highlights an important point on the perfect tolerance of the daily intake of extract standardized to 36 mg of PACs. It is important to note that the principle of standardization only applies to specific extracts, and does not apply to other types of preparations such as cranberry juice. Finally, validating the exact PAC concentration of an extract requires a reference methodology validated and institutionalized by major regulatory authorities: this is the method called BL-DMAC [17].

D-mannose  [18–20]
D-Mannose is a monosaccharide, a sugar, naturally present in the body. It is also found in our diet, especially in fruits such as cranberries. Although D-mannose is a simple sugar (like glucose), however, it is not metabolized by the body. Indeed, pharmacokinetic data on the ingestion of D-mannose has shown that at least 90% of this sugar is absorbed and reaches the bloodstream and ends up intact in the urine. Its urinary excretion is linked to its local mechanistic effects: by binding to certain pathogens such as E.coli, D-mannose would limit its adhesion to the mucosa. The compilation of clinical studies also proves the very good tolerance and efficacy of D-mannose in the form of a daily oral intake of 2 g and more.

Nutri&Co's choice
Like all of our formulas, this is of course the effectiveness that we aim for with our Cranberry Mannose formula. To effectively combat urinary discomfort, we have opted for a combination of 4 judiciously developed active ingredients:

  1. High dosages without concession in reference ingredients:
    1. High dosages without concession in reference ingredients:
      • The patented cranberry / cranberry extract, Urophenol®, is highly specific thanks to its polyphenol profile (use of whole cranberry fruit) and the variety from which it is derived. It is supported by its own clinical study [21] based on a unique and original protocol [22], comparing the efficacy of the extract at 36 mg of PACs versus an extract with very low PACS content (2 mg). This extract therefore goes further than a simple cranberry juice low in PACs: a total of 240 mg of an extract standardized to 36 mg of PACs and analyzed according to the official BL-DMAC method that we have put in our formula,
      • Another proven ingredient: D-mannose, which we have chosen to dose at 4 g daily, which is double the smallest dose with clinically proven effectiveness. Thus, 1 single daily stick already provides the minimum effective dose of D-mannose of 2 g.
    2. 2 other extracts with additional benefits :
      • An extract of hibiscus flower (Hibiscus sadbariffa): the ElliroseTM extract which presents, thanks to its patented extraction process, a particular profile in organic acids (> 40%) and polyphenols (> 45%), including 'swimming pool, and known for their antimicrobial activity. In preliminary studies, analysis of the bioavailability of ElliroseTM has shown that its compounds are found intact in the urine. More recently, a clinical study was conducted on 40 women with recurrent urinary tract infections treated with 200 mg of ElliroseTM per day. The results showed that after 3 months of use, the women not only exhibited very good tolerance to the extract, but above all an improvement in the functioning of the urinary tract [23], and therefore restored urinary comfort.
      • Pomegranate extract (Punica granatum): the selected pomegranate fruit extract, Pomanox®, is patented and standardized in punicalagins (> 30%), including ellagitannins with ellagic acid. Ellagic acid is known to be metabolized in the body by the microbiota to form urolithins A and B. At the urinary level, the pomegranate seems interesting for its antibacterial activity [24–27].
    3. A format designed for optimal efficiency :
      • A powder formula to be diluted which encourages and promotes water intake: the first hygienic and dietary rule to apply in the event of urinary discomfort.
      • Sticks that are easy and practical to use and transport on a daily basis and which allow us a formula with a high dosage of active ingredients (which would have been impossible in the form of capsules).
      • A natural cherry flavoring to make it easier to set, and last until the end of 10 days.
      • The entire effective dose in 1 single box: 20 sticks for 10 days of intake (2 stickers per day).

    Publications

    1. Wagenlehner, F.M.E.; Bjerklund Johansen, T.E.; Cai, T.; Koves, B.; Kranz, J.; Pilatz, A.; Tandogdu, Z. Epidemiology, Definition and Treatment of Complicated Urinary Tract Infections. Nat. Rev. Urol. 2020, 17, 586–600, doi:10.1038/s41585-020-0362-4.
    2. Flores-Mireles, A.L.; Walker, J.N.; Caparon, M.; Hultgren, S.J. Urinary Tract Infections: Epidemiology, Mechanisms of Infection and Treatment Options. Nat. Rev. Microbiol. 2015, 13, 269–284, doi:10.1038/nrmicro3432.
    3. Medina, M.; Castillo-Pino, E. An Introduction to the Epidemiology and Burden of Urinary Tract Infections. Ther. Adv. Urol. 2019, 11, 175628721983217, doi:10.1177/1756287219832172.
    4. Foxman, B.; Barlow, R.; D’Arcy, H.; Gillespie, B.; Sobel, J.D. Urinary Tract Infection: Self-Reported Incidence and Associated Costs. 2000, 10, 7.
    5. Zowawi, H.M.; Harris, P.N.A.; Roberts, M.J.; Tambyah, P.A.; Schembri, M.A.; Pezzani, M.D.; Williamson, D.A.; Paterson, D.L. The Emerging Threat of Multidrug-Resistant Gram-Negative Bacteria in Urology. Nat. Rev. Urol. 2015, 12, 570–584, doi:10.1038/nrurol.2015.199.
    6. Colgan, R.; Williams, M. Diagnosis and Treatment of Acute Uncomplicated Cystitis. 2011, 84, 6.
    7. Foxman, B.; Buxton, M. Alternative Approaches to Conventional Treatment of Acute Uncomplicated Urinary Tract Infection in Women. Curr. Infect. Dis. Rep. 2013, 15, 124–129, doi:10.1007/s11908-013-0317-5.
    8. HAS Cystite Aiguë Simple, à Risque de Complication Ou Récidivante, de La Femme Available online: https://www.has-sante.fr/jcms/c_2722827/fr/cystite-aigue-simple-a-risque-de-complication-ou-recidivante-de-la-femme.
    9. AFU CYSTITES RÉCIDIVANTES : DES MOYENS DE PRÉVENTION NON MÉDICAMENTEUX Available online: https://www.urofrance.org/base-bibliographique/cystites-recidivantes-des-moyens-de-prevention-non-medicamenteux.
    10. Costantini, E.; Giannitsas, K.; Illiano, E. The Role of Nonantibiotic Treatment of Community-Acquired Urinary Tract Infections. Curr. Opin. Urol. 2017, 27, 120–126, doi:10.1097/MOU.0000000000000366.
    11. Cai, T.; Tamanini, I.; Kulchavenya, E.; Perepanova, T.; Köves, B.; Wagenlehner, F.M.E.; Tandogdu, Z.; Bonkat, G.; Bartoletti, R.; Bjerklund Johansen, T.E. The Role of Nutraceuticals and Phytotherapy in the Management of Urinary Tract Infections: What We Need to Know? Arch. Ital. Urol. E Androl. 2017, 89, 1, doi:10.4081/aiua.2017.1.1.
    12. Loubet, P.; Ranfaing, J.; Dinh, A.; Dunyach-Remy, C.; Bernard, L.; Bruyère, F.; Lavigne, J.-P.; Sotto, A. Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections. Front. Microbiol. 2020, 11, 1509, doi:10.3389/fmicb.2020.01509.
    13. Blumberg, J.B.; Camesano, T.A.; Cassidy, A.; Kris-Etherton, P.; Howell, A.; Manach, C.; Ostertag, L.M.; Sies, H.; Skulas-Ray, A.; Vita, J.A. Cranberries and Their Bioactive Constituents in Human Health. Adv. Nutr. 2013, 4, 618–632, doi:10.3945/an.113.004473.
    14. González de Llano, D.; Liu, H.; Khoo, C.; Moreno-Arribas, M.V.; Bartolomé, B. Some New Findings Regarding the Antiadhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Bacteria. J. Agric. Food Chem. 2019, 67, 2166–2174, doi:10.1021/acs.jafc.8b05625.
    15. Jepson, R.G.; Williams, G.; Craig, J.C. Cranberries for Preventing Urinary Tract Infections. Cochrane Database Syst. Rev. 2012, doi:10.1002/14651858.CD001321.pub5.
    16. Fu, Z.; Liska, D.; Talan, D.; Chung, M. Cranberry Reduces the Risk of Urinary Tract Infection Recurrence in Otherwise Healthy Women: A Systematic Review and Meta-Analysis. J. Nutr. 2017, 147, 2282–2288, doi:10.3945/jn.117.254961.
    17. Haesaerts, G. Le dosage des proanthocyanidines (PAC) de cranberry dans les compléments alimentaires: enjeux et derniers développements. Phytothérapie 2010, 8, 218–222, doi:10.1007/s10298-010-0575-4.
    18. Altarac, S.; Papeš, D. Use of D-Mannose in Prophylaxis of Recurrent Urinary Tract Infections (UTIs) in Women: Comment. BJU Int. 2014, 113, 9–10, doi:10.1111/bju.12492.
    19. De Nunzio, C.; Bartoletti, R.; Tubaro, A.; Simonato, A.; Ficarra, V. Role of D-Mannose in the Prevention of Recurrent Uncomplicated Cystitis: State of the Art and Future Perspectives. Antibiotics 2021, 10, 10.
    20. Scaglione, F.; Musazzi, U.M.; Minghetti, P. Considerations on D-Mannose Mechanism of Action and Consequent Classification of Marketed Healthcare Products. Front. Pharmacol. 2021, 12, 636377, doi:10.3389/fphar.2021.636377.
    21. Babar, A.; Moore, L.; Leblanc, V.; Dudonné, S.; Desjardins, Y.; Lemieux, S.; Bochard, V.; Guyonnet, D.; Dodin, S. High Dose versus Low Dose Standardized Cranberry Proanthocyanidin Extract for the Prevention of Recurrent Urinary Tract Infection in Healthy Women: A Double-Blind Randomized Controlled Trial. BMC Urol. 2021, 21, 44, doi:10.1186/s12894-021-00811-w.
    22. Asma, B.; Vicky, L.; Stephanie, D.; Yves, D.; Amy, H.; Sylvie, D. Standardised High Dose versus Low Dose Cranberry Proanthocyanidin Extracts for the Prevention of Recurrent Urinary Tract Infection in Healthy Women [PACCANN]: A Double Blind Randomised Controlled Trial Protocol. BMC Urol. 2018, 18, 29, doi:10.1186/s12894-018-0342-7.
    23. Allaert, F.A. Prevention of Recurrent Cystitis in Women: Double-Blind, Placebo- Controlled Study of Hibiscus Sabdariffa L. Extract. Lett. L’Infectiologue 2010, 5.
    24. Espín, J.C.; González-Barrio, R.; Cerdá, B.; López-Bote, C.; Rey, A.I.; Tomás-Barberán, F.A. Iberian Pig as a Model To Clarify Obscure Points in the Bioavailability and Metabolism of Ellagitannins in Humans. J. Agric. Food Chem. 2007, 55, 10476–10485, doi:10.1021/jf0723864.
    25. Howell, A.B.; D’Souza, D.H. The Pomegranate: Effects on Bacteria and Viruses That Influence Human Health. Evid. Based Complement. Alternat. Med. 2013, 2013, 1–11, doi:10.1155/2013/606212.
    26. Zam, W.; Khaddour, A. Anti-Virulence Effects of Aqueous Pomegranate Peel Extract on E. Coli Urinary Tract Infection. Prog. Nutr. 2017, 19, doi:10.23751/pn.v19i1-S.5693.
    27. Ammar, O.M.A.; Ilktac, M.; Gulcan, H.O. Urolithins and Their Antimicrobial Activity: A Short Review. EMUJPharmSci 2020, 8.
Sans sucres ajoutes No added sugar
Sans edulcorants Without sweeteners
Sans additifs without additives
100% vegan 100% vegan
Made in france Made in france

Have a question?

Our experts answer to all your questions.

How long does it take to work?

We recommend following a program of 10 consecutive days, at the rate of 2 sticks daily to ensure the effectiveness of the formula.

What is a urinary tract infection?

A urinary tract infection is a bacterial infection that occurs in the urinary system. It is called cystitis when the inflammation due to the infection particularly affects the bladder. Urinary tract infections affect an average of 1 in 2 women during their lifetime and can be recurrent, that is, repeating 3 to 4 times in the same year.

Is the product diuretic?

Yes, our Cranberry Mannose is a formula made for a diuretic action promoting elimination.

Why is it recommended to drink lots of water when you have a urinary tract infection?

Drinking is one of the first hygienic and dietary recommendations of the health authorities. Combined with the diuretic action of the formula, the drink promotes the desire to eliminate and therefore optimize the expulsion of pathogens through the urine flow.

Why not essential oils in your formula?

Some products on the market actually offer essential oils to promote urinary comfort. We have of course looked at this option, but the rationale and level of scientific evidence is more in favor of the cranberry / mannose / hibiscus / pomegranate mix. Indeed, all our formulas are based on a prior study of the scientific literature for each of the product indications and the establishment of the ideal specifications. In addition, the use of essential oils can lead to use restrictions, and at Nutri & Co, we want to create formulas adapted to the greatest number and with a minimum of restrictions!

Why not have probiotics in your formula?

More and more formulas offer probiotics to improve urinary comfort. The idea is to promote the intestinal flora, which will itself promote the vaginal flora, leaving less room for the pathogenic bacterial proliferation that causes cystitis. Scientifically, the approach is therefore to "boost" its intestinal flora, and for this you can of course use our Probio2. Yes, but here it is, combining probiotics and mannose impairs the effectiveness of supplementation, since mannose can neutralize the effect of probiotics. This is why we have chosen a formula without probiotics, but it will be quite possible for you to adopt our Probio2 after taking our Cranberry Mannose.

Does it work for men?

No. Urinary tract infections and discomfort are predominantly female problems due to the anatomy of the female urinary system. We developed our formula for women based on scientific studies of its active ingredients in women. Thus, we cannot guarantee efficacy in men for whom urinary tract infections have different origins and require other solutions.

Is the effect as quick as an antibiotic?

In times of cystitis, the first recommendation is to follow any antibiotic treatment that would have been prescribed on medical advice. If, however, our Cranberry Mannose is taken as an alternative, then it is essential to ensure supplementation over the entire 10 days required, and to carefully observe the development of urinary discomfort. The observed efficacy may vary from person to person, and depending on when you start taking it.

Should I take it for prevention or at the onset of the urinary tract infection?

Both ! If our Cranberry Mannose is above all a prevention formula with its high dosages of reference active ingredients, it can also be used alone as a rapid reaction to the first recognized signs and felt of urinary discomfort. Indeed, after several recurrences, self-diagnosis at the first signs becomes easier. If an antibiotic treatment has also been prescribed to treat the infection, then our formula can be perfectly combined.

Can I take it at the same time as my antibiotic treatment?

Absolutely, in the event of a crisis, our Cranberry Mannose can be used in addition to the antibiotics that would be prescribed. It can also be used preventively, without antibiotics, at the first warning signs or during periods more conducive to the onset of urinary discomfort.

Where do our ingredients come from?

Origine des ingrédients du Magnésium
Mixing and production of sticks
Nutrisun Manufacture of sticks: Chateaubourg, France

For more than 25 years, Nutrisun has been recognized as an expert in the development of food and nutraceutical products, with specific know-how in flavoring and other organoleptic aspects.

D-mannose - Keb via Vivatis France Origin of D-mannose: China
Manufacture: China

Keb Biotechnology was established in 2000 in Mongolia. Its mastery of the development of nutraceutical ingredients from A to Z (farms, R&D centers and production workshops) makes it a partner of absolute trust. D-Mannose is made from corn glucose through a natural fermentation process.

Cranberry / cranberry fruit extract
Urophenol® • Diana Food Origin of cranberries: Canada and USA
Manufacturing: Canada

Diana Food is a company founded in 1990 in Rennes. It is one of the major global players in the development of functional ingredients and natural flavors. & Lt;
Urophenol ® is a perfect illustration of Diana Food's commitment to developing active ingredients of clinically documented health. Diana Food works in partnership with the University of Laval in Canada to understand the mechanisms of action of PACs.

Passion fruit juice powder
Diana Food Manufacture: Rennes, France

Origin of passion fruit: Ecuador, Peru and Vietnam
Diana Food is a company founded in 1990 in Rennes. It is one of the major global players in the development of functional ingredients and natural flavors.

Passion fruit juice powder • Diana Food
Origin of cranberries: Canada and USA
Diana Food is a company founded in 1990 in Rennes. It is one of the major global players in the development of functional ingredients and natural flavors.

Hibiscus flower extract
Ellirose ™ • Naturex Hibiscus origin: Sudan and West Africa

Extraction: Avignon, France
Created in 1992, Naturex is an international leader in the development of natural ingredients in the fields of food, health and beauty.

Pomegranate fruit extract
Pomanox® • Euromed Origin of the pomegranate: Spain
Extraction: Mollet del Vallès, Spain

Euromed is a company founded in 1971 which recently celebrated 50 years of discovery, production and study of botanical extracts with high added value.

Cherry flavor • Silesia Manufacturing: Neuss, Germany

Silesia is an international company that develops new generation organoleptic solutions. 100% natural, this ingredient allows our formula to naturally and subtly flavor.

Map Mobile

Where do our ingredients come from?

Mixing and production of sticks • Nutrisun

Manufacturing of sticks: Chateaubourg, France

For more than 25 years, Nutrisun has been recognized as an expert in the development of food and nutraceutical products, with specific know-how in flavoring and other organoleptic aspects.

D-mannose - Keb via Vivatis France

Origin of D-mannose: China • Manufacturing: China < / span>

Keb Biotechnology was established in 2000 in Mongolia. Its mastery of the development of nutraceutical ingredients from A to Z (farms, R&D centers and production workshops) makes it a partner of absolute trust. D-Mannose is made from corn glucose through a natural fermentation process.

Cranberry / cranberry fruit extract • Urophenol® • Diana Food

Origin of cranberries: Canada and USA • Manufacturing: Canada

Diana Food is a company founded in 1990 in Rennes. It is one of the major global players in the development of functional ingredients and natural flavors. & Lt;
Urophenol ® is a perfect illustration of Diana Food's commitment to developing active ingredients of clinically documented health. Diana Food works in partnership with the University of Laval in Canada to understand the mechanisms of action of PACs.

Passion fruit juice powder • Diana Food

Manufacturing: Rennes, France

Origin of passion fruit: Ecuador, Peru and Vietnam
Diana Food is a company founded in 1990 in Rennes. It is one of the major global players in the development of functional ingredients and natural flavors.

Hibiscus flower extract • Ellirose ™ • Naturex

Origin of hibiscus: Sudan and Africa of the West

Extraction: Avignon, France
Created in 1992, Naturex is an international leader in the development of natural ingredients in the fields of food, health and beauty.

Pomegranate fruit extract • Pomanox® • Euromed

Origin of the pomegranate: Spain • Extraction: Calf del Vallès, Spain

Euromed is a company founded in 1971 which recently celebrated 50 years of discovery, production and study of botanical extracts with high added value.

Cherry flavor • Silesia

Manufacturing: Neuss, Germany

Silesia is an international company that develops new generation organoleptic solutions. 100% natural, this ingredient allows our formula to naturally and subtly flavor.

Our certified customer reviews

Those who we tested Cranberry approved it.
Based on 1 reviews
5,0/5
Après mes calculs rénaux j’ai retrouvé le confort !
01.09.2021
All our customer reviews

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