Immunity • Antioxidant
90 capsules • from 2/day
Immunity • Antioxidant
90 capsules • from 2/day
Essential for the proper functioning of the body, vitamins and minerals are not always present in sufficient quantities in Western diets*.
Multivitamins thus appear as the keystone of all health prevention strategies.
Rather than developing yet another catch-all formula, we focused on 27 key active ingredients adapted to all: bio-active vitamins, plant D3, high absorption minerals, plant extracts, CoQ10...
- Immunity & Antioxidant
25 essential active ingredients
Our complex focuses on nutrients that are difficult to find in food. Our dosages are based on clinical studies that have demonstrated their health benefits. It contains 14 vitamins, 4 minerals, 2 carotenoids, 3 bio-flavonoids, coenzyme Q10 and is free from pro-oxidant minerals (iron, copper and manganese).
Natural and bio-active vitamins
No more artificial forms! We have selected new so-called “ready-to-use” vitamins such as P-5-P (B6), Quatrefolic® folate (B9), methylcobalamin (B12) or even vitamins A, E and D3 in the form of vegetable.
A new magnesium salt!
For the first time a magnesium combining content AND absorption takes place in a multi-vitamins. It reduces the number of capsules / day while maintaining high efficiency.
This blend of bio-identical nutrients has been selected with the aim of embracing a maximum benefits.
- Folate, vitamins B12, D3, zinc and magnesium play a role in cell division,
- Vitamins B2, C, E, zinc and selenium help protect cells against oxidative stress,
- Vitamin C contributes to the regeneration of the reduced form of vitamin E,
- Vitamin A plays a role in the process of cellular specialization,
- Vitamin B12 contributes to the normal formation of red blood cells,
- Vitamin B2 contributes to the maintenance of normal red blood cells,
- Vitamin K contributes to normal blood clotting,
- Zinc contributes to the normal metabolism of vitamin A,
- folate contributes to the normal formation of the blood,
- Zinc contributes to the normal synthesis of DNA.
- Vitamins B2, B6, B8, B12, C and magnesium contribute to the normal functioning of the nervous system,
- Vitamins B3, B6, B8, B9, B12, C and magnesium contribute to normal psychological functions,
- Vitamin B5 contributes to the normal synthesis and metabolism of the steroid hormones of vitamin D and certain neurotransmitters,
- Vitamin B5 contributes to normal intellectual performance,
- Zinc contributes to normal cognitive function.
- Vitamins B2, B3, B5, B6, B8, B12 and C and magnesium contribute to a normal energy metabolism,
- Vitamins B2, B6, B8 , B12, C and magnesium contribute to the normal functioning of the nervous system,
- Vitamins B2, B3, B5, B6, B9, B12, C and magnesium help reduce fatigue,
- D3 and magnesium help maintain normal muscle function.
Key enzyme syntheses
- Vitamin B8 and zinc contribute to normal macronutrient metabolism,
- Vitamin B6 contributes to normal protein and glycogen metabolism,
- Vitamins B9 and B12 contribute to the normal metabolism of homocysteine,
- Magnesium and zinc contribute to normal protein synthesis,
- Folate contributes to the normal synthesis of acids amino,
- Zinc contributes to normal fatty acid metabolism,
- Zinc contributes to normal carbohydrate metabolism.
- Vitamin C and zinc help maintain the normal functioning of the immune system, during and after intense physical exercise,
- Vitamins A, B9 , B12, D3 and selenium contribute to the normal functioning of the immune system.
- Vitamins A, B2 and zinc help maintain normal vision.
- Vitamins A, B2, B3 and B8 contribute to the maintenance of normal mucous membranes.
- Zinc contributes to normal fertility and reproduction le,
- Selenium contributes to normal spermatogenesis.
Pregnancy & lactation
- D3 is necessary for normal growth and bone development in children,
- Folate contributes to the growth of maternal tissues during pregnancy,
- Vitamins A, B2 and C contribute to normal iron metabolism,
- Selenium contributes to normal thyroid function.
- Vitamins D3, K, zinc and magnesium contribute to the maintenance of normal bones,
- D3 contributes to a level of calcium in the blood ( calcemia) normal,
- Magnesium contributes to the maintenance of normal teeth.
- Zinc contributes to normal acid-base metabolism,
- Magnesium contributes to electrolyte balance.
- Vitamin C contributes to the normal formation of collagen to ensure the normal function of the gums, blood vessels, cartilage and skin,
- Vitamin B8, zinc and selenium help maintain normal hair,
- Vitamins A, B2, B3 and B8 help maintain normal skin,
- Zinc and selenium help maintain normal nails.
When to take Multivitamins?
- The Multi should be taken with breakfast.
How many capsules?
- Children: Not recommended.
- Adolescents: 1 capsule per day (open) *.
- Adults: 3 capsules per day.
* Adolescents who may have difficulty swallowing capsules, we recommend that you open them and pour the contents into a glass of water, yogurt or compote.
Duration of a dose
- The Multi represents the daily nutraceutical gesture par excellence!
How to take your capsules?
- To be taken with a large glass of water, quite simply.
Duration of a flask
- The bottle of Multi lasts 30 days, at 3 capsules per day.
Precautions for use
- Multivitamin food supplement, to be used in addition to a healthy and balanced diet.
- Do not exceed the recommended daily doses.
- pregnant or breastfeeding women should seek medical advice before any supplementation.
- Not suitable for children under 10 years of age.
- People on anticoagulants should seek advice from their doctor before any supplementation.
- Store in a dry place away from light and heat.
- Keep out of the reach of children.
For 3 capsules Quantity NRV* For 3 capsules Quantité Vitamins Co-factors Vitamin A (from Dunaliela) 800 μg 100% N-Acetyl-Cysteine 180 mg Vitamin B1 (Thiamine HCL) 2,2 mg 200% Alpha Lipoic Acid (form R) 50 mg Vitamin B2 (Riboflavin) 2,8 mg 200% Rutin (extract of S. japonica) 32 mg Vitamin B3 (Nicotinamide) 16 mg 100% Hesperidin (citrus extract) 32 mg Vitamin B5 (Calcium pantothenate) 6 mg 100% CoEnzyme Q10 30 mg Vitamin B6 (Pyridoxal-5-phosphate) 2 mg 143% Quercetin (extract of S. japonica) 20 mg Vitamin B7 (Inositol) 30 mg - Montein (tagetes extract) 7 mg Vitamin B8 (Biotin) 51 μg 100% Lycopene (tomato extract) 1 mg Vitamin B9 (Quatrefolic®) 200 μg 100% Vitamin B12 (Methylcobalamin) 2,7 μg 100% Autres ingrédients Vitamin C ( L-Ascorbic acid) 80 mg 100% Magnesium sucrosome, Capsule of vegetable origin HPMC, N-acetyl-L-cysteine, Alpha lipoic acid, Nu-RICE®, Zinc gluconate, Ascorbic acid, Dunaliela extract, Menaquinone-7, Rutin, Hesperidin, CoQ10, Inositol, d-alpha-tocopheryl acetate, Quercetine, Nicotinamide, Selenie yeast, Tagetes extract, Lichen cholecalciferol, Rockweed extract, Calcium pantothenate, Tomato extract, Pyridoxal-5-phosphate, Riboflavin, Thiamine HCL, (6S)-5-methyltetrahydrofolic acid, Methylcobalamin, Chromium piccolinate, Biotin. Vitamine D3 (Cholecalciferol de lichen) 1000 UI 500% Vitamin E (Nutrabiol®) 12 mg 100% Vitamin K2 (K2VITAL® DELTA) 80 μg 107% Minerals Magnesium element (UltraMag®) 150 mg 40% Zinc element (Gluconate) 10 mg 100% Selenium (Selenium yeast) 30 μg 54% Iodine (Rockweed extract) 10 μg 6,7% Element chromium (Chromax®) 25 μg 62%
*NRV : nutritional reference values
Vitamins, essential micronutrients
Vitamins belong to the category of micronutrients (also including minerals and trace elements). The latter are components that derive mainly from our diet because they are not synthesized by our body. Micronutrients are required in small quantities for our vital development, the prevention of pathologies and our general well-being . Every day, our organism needs vitamins for its physiological homeostasis, which are found in our diet. There are two categories of vitamins: water-soluble vitamins, i.e. soluble in water (group B and C vitamins), and fat-soluble vitamins, i.e. soluble in fat (vitamins A, D, E and K).
Vitamin B5 (Pantothenic acid)Mushrooms, liver, eggs, abas, certain poultry and cheese
Vitamins Food sources*
Foods richest in g of vitamin per 100 g of food
Hydrosoluble vitamins Vitamin B1 (Thiamine) Food yeast, cereal bran, cereals, oilseeds, pork Vitamin B2 (Riboflavin) Liver, giblets, eggs, certain cheeses and mushrooms Vitamin B3 (Nicotinamide) Sound of cereals, liver, fatty fish, poultry and other meats Vitamin B6 (Pyridoxine) Dried aromatic herbs, cereal bran, poultry liver and giblets, oilseeds Vitamin B7 (Inositol)/Vitamin B8 (Biotin) Liver, eggs, fish and meat, legumes, mushrooms, sprouted seeds Vitamin B9 (Folic acid) Liver, food yeast, legumes, oilseeds, germinated seeds, giblets, spinach, dried aromatic herbs Vitamin B12 (Cobalamine) Liver, gut, shellfish, fatty fish and other fish Vitamin C (Ascorbic acid) Raw food: guava, blackcurrant, parsley, pepper, lemon, cabbage, kiwi, citrus fruit Fat-soluble vitamins Vitamin A (Retinol) Dried aromatic herbs, liver, tuna, dried mushrooms
Foods rich in provitamin A carotenoids (beta-carotene): carrots, sweet potato, spinach, squash
Vitamin D (Calciferol) Cod liver oil, cod liver, fatty fish, fish eggs and some margarines Vitamin E (Tocopherol) Wheat germ oil and other vegetable oils, oilseeds Vitamin K (K1: Phylloquinone and K2: Menaquinone) Vitamin K1: dried aromatic herbs, cabbage, spinach, salads.
Vitamin K2: liver, butter, poultry, yoghurts
*The nutritional composition of foods can be consulted on the site of the ANSES, National Agency for Food, Environmental and Occupational Health Safety.
Consumption of vitamins
Vitamins do not all come from the same foods, it is therefore necessary to have a varied consumption (foods from different major food groups) but also a diversified diet (foods from the same food group). Micronutrients have no energy value (basically, they do not intervene directly on our energy balance, neither to lose weight nor to gain weight!) compared to macronutrients, which have a direct and significant impact (carbohydrates, lipids and proteins). The ESFA (European Food Safety Authority) has established Nutrient Reference Values (NRVs, formerly known as RDAs: Daily Reference Intakes) for the vitamins summarised in the table below :
Vitamins Adult NRV
Quantity per day
Vitamin B1 (Thiamine) 0,1 mg / consumed energy
For individual at 2200 Kcak/d = 0.91 mg
Vitamin B2 (Riboflavin) 1,6 mg Vitamin B3 (Nicotinamide) 1,6 mg / consumed energy
For individual at 2200 Kcak/d= 14.6 mg
Vitamie B5 (Pantothenic acid) 5 mg Vitamin B6 (Pyridoxine) 1.7 mg (Men)
1.6 mg (Women)
Vitamin B8 (Biotin) 40 μg Vitamin B9 (Folic Acid) 330 μg
(in dietary folate*)
Vitamin B12 (Cobalamine) 4 μg Vitamin C (Ascorbic acid) 110 mg (Men)
95 mg (Women)
Vitamin A (Retinol) 750 μg Vitamin D (Calciferol) 15 μg (600 UI) Vitamin E (Tocopherol) 13 mg (Men)
90 mg (Women)
Vitamin K (Phylloquinone) 70 μg
*Dietary folate is less well assimilated than folic acid.
On the other hand, these NRVs, and therefore the needs, evolve according to certain specific physiological situations, particularly in pregnant or breastfeeding women and the elderly. During pregnancy, the need for vitamin B12 (increasing from 4 to 4.5 μg per day) and folate (increasing from 330 to 600 μg per day) is increased. During breastfeeding, the need for vitamin A (from 750 to 1300 μg per day) and vitamin C (from 95 to 155 mg per day) is also increased. These data suggest the importance of the pre-conceptional period, when optimal nutritional status would help to ensure "reserves" of micronutrients for the periods of pregnancy and breastfeeding, which are critical for the future health of the newborn. Finally, the elderly are more exposed to nutritional deficits due to a decrease and changes in micronutrient absorption  as well as changes in consumption (reduced appetite, pronounced dietary choices for foods loaded with flavour, etc.). There are other reasons that can generate deficiencies beyond the physiological status in which we find ourselves. Indeed, they can result from simply poor diets or from other types of factors such as absorption defects linked to intestinal pathologies or even to the taking of medication .
On the other hand, it is also less obvious to detect our consumption levels of micronutrients because they have varied and less well known origins, making it more difficult to highlight a possible targeted "deficiency" ("I don't eat enough of this food so I don't consume enough of this vitamin").
A key question seems to be: can we really claim an optimal consumption profile in our current food models? Unfortunately, the food transitions we have faced and are still facing are extremely rapid and abrupt. We have moved from traditional consumption patterns characterized by high nutritional density to modern consumption patterns characterized by high energy density [4,5], which are real public health issues. More concretely, these changes have led to a decrease in the quality of our food (decrease in the consumption of essential micronutrients and fibre), particularly associated with the intensification of industrial processes (increase in the consumption of fat/sugar and industrial products; decrease in the quality of foods rich in essential micronutrients, particularly vitamins) . In addition to these dietary parameters, lifestyles and environments constrain the attainment of certain vitamin requirements such as vitamin D (80% of vitamin D comes from photoconversion in the skin by UVB (sunlight) .
Finally, the problem is not essentially based on whether our diet is complete (balanced) or not. It is a question of accepting that the human species is a formidable adaptation machine, but that its corollary implies that we are never 100% adapted to a given biotope and therefore to 100% of our intake in the long term. Today, nutraceuticals offer the possibility to meet or even exceed these needs in order to ensure our well-being and health for the future.
Choosing your Multivitamins: carefully selected vitamins at Nutri&Co
Here we give you some keys but above all some essential information to take the right direction in terms of multivitamins, because history repeats itself, there is a wide variety of products on the market. To benefit from the effects of vitamins, you need to be sure that they reach their targets, ideally in an active (= "ready-to-use") form. This is what defines the famous bioavailability, corresponding to the quality that a nutrient has to be able to be absorbed by the intestinal mucosa and to be used efficiently. Several criteria are taken into account to ensure the bioavailability of a compound and in particular its form (specific structure of the molecule). Indeed, some forms are said to be bioactive, i.e. they correspond to the form in which they can be used by the organism, which facilitates the work of assimilation of the latter .
How about a concrete example? Let's talk about vitamin B9 (folic acid from dietary folates). Within the Nutri&Co formula, vitamin B9 has been selected in the form of Quatrefolic. The latter corresponds to 5-Methyltetrahydrofolate (5-MTHF) which is a reduced form of folate. Supplementing this bioactive form also makes it possible to obtain a high bioavailability of vitamin B9 by "short-circuiting" the formation of intermediate molecules. In fact, when the body ingests "standard" folic acid, it must transform it 4 times before obtaining the active form such as Quatrefolic®. These successive transformations obviously generate losses, but also random efficacy, with a strong disparity between individuals .
The combination of bioactivity and bioavailability makes it possible to provide the Multivitamins with a bioidentical form of vitamin B9.
It is in this approach to effectiveness, and after more than a year of research, that Nutri&Co has systematically chosen vitamins in their bioactive form. .
Vitamins, but also minerals and co-factors
In addition to vitamins, our formula also combines the presence of magnesium, trace elements (small-sized minerals) and co-factors that complement the action of supporting physiological reactions, while taking great care to eliminate potentially pro-oxidising or "antagonistic" minerals (iron and manganese in particular).Moreover, calcium has also not been included in our Multi, as the current scientific consensus highlights the sufficient dietary intake of calcium in the French population.
An example of a crucial trace element for our body is zinc. It is mainly found in red meats, certain seeds, shiitake mushrooms and shellfish. In moderate deficiencies, disturbances can be observed such as growth retardation, hypogonadism in young adolescents, healing defects, immune system response defects or neurosensory changes . Three capsules of our multi provides 100% of the NRVs in a Gluconate form, perfectly well assimilated and usable by the body.
With regard to iodine, marine products are known to contain the highest concentration. Depending on their importance, possible deficiencies can have consequences at all ages, from the fetus to adulthood, ranging from developmental problems to neurological disorders. Coverage of iodine intake appears to be particularly important in the periconceptional period up to childhood . Iodine supplementation is not systematic and yet iodine seems to have an important position in clinical practices related to specific nutritional recommendations in the periconceptional period .
Among the co-factors selected in the Multivitamin, we find in particular :
- Coenzyme Q10, a molecule produced by the organism involved in the processes of energy production and defence against oxidation of cell membranes,
- Quercetin, a polyphenol that fights cellular aggression,
- Lutein and lycopene, both from the family of carotenoids known for their antioxidant role,
This combination therefore increases the antioxidant potential of our body  by molecules of various origins and normally poorly bioavailable.
Although vitamins and minerals act synergistically and via complex mechanisms, each has physiological roles that can be briefly listed (biological role tables). These major implications in our physiological balance give vitamins and minerals major axes of activity: vitality, tonus, immunity and antioxidant supply. During particular physiological situations such as pregnancy, meeting the needs for certain vitamins (especially vitamins B9 and D) and minerals (zinc and iodine) is crucial. Indeed, beyond the functions of maintaining our physiological balance, micronutrients also play a primordial role in periods of increased development.
Vitamins Biological roles Vitamin B1 (Thiamine) Supports energy metabolism (cofactor in the conversion of carbohydrates to energy), nerve and muscle functions Vitamin B2 (Riboflavin) Supports energy metabolism (cofactor in the respiratory chain, component of coenzymes), vision and skin Vitamin B3 (Nicotinamide) Supports energy metabolism (respiratory chain cofactor), nerve function and improves lipid profiles and skin health Vitamin B5 (Pantothenic acid) Supports energy metabolism Vitamin B6 (Pyridoxine) Plays a role in the metabolism of amino acids (cofactor of about 100 enzyme reactions) and fatty acids, in red blood cell production, and heart health Vitamin B7 (Inositol) / Vitamin B8 (Biotin) Plays a role in bone and hair health, in the conversion of nutrients to energy, and in the synthesis of lipids, amino acids and glycogen (endogenous carbohydrate reserves in the body) Vitamin B9 (Folic acid) Participates in DNA synthesis (genetic material), cofactors required for methylation reactions, and allows the formation of new cells and supports heart health Vitamin B12 (Cobalamin) Plays a role in heart health, the production of new cells, in the hydrolysis of amino and fatty acids and supports the maintenance of nerve cells, interacts with the metabolism of vitamin B9 Vitamin C (Ascorbic acid) Plays a role in the synthesis of new cells, in the hydrolysis of fatty acids and amino acids, supports the maintenance of nerve cells (synthesis of hormones and neurotransmitters), acts as an antioxidant, plays a role in the immune system, facilitates the absorption of non-heme iron (from plants), allows the recycling of vitamin E Vitamin A (Retinol) Supports vision, skin and bones, immunity and reproduction, acts as an antioxidant Vitamin D (Calciferol) Plays a role in bone metabolism (bone mineralization), maintains calcium and phosphorus levels in the blood to strengthen bones Vitamin E (Tocopherol) Antioxidant regulating oxidation reactions, protects cell membranes and body compounds (lipids, enzymes...) Vitamin K (K1 : Phylloquinone and K2: Menaquinones) Play a role in the coagulation of proteins in the blood and regulates blood calcium
(Data from [14,15])
Minerals Biological roles Magnesium Find all the importance of magnesium in our physiological functions in the science section of ourMagnesium Zinc Involved in the structure and catalytic activity of many enzymes, plays a role in the function of the immune system, wound healing, protein synthesis, DNA synthesis and cell division, required in the perception of taste and odour, acts as an antioxidant Selenium Plays a role in immune functions, acts as an antioxidant Iodine Plays a role as an essential constituent of thyroid hormones, involved in the general process of development and growth
(Data from )
In conclusion, multivitamin supplementation very often raises the notion of "safety". Beyond the quality of the selected nutraceutical ingredients (origin, efficacy...), it is important to take into account the notion of "dose". We must not confuse NRVs (Nutritional Reference Values), which are thresholds below which we are potentially deficient (different NRVs between regulatory values for labelling and values defined by type of population), and MDIs (Maximum Daily Intakes) which represent the limits not to be exceeded in a supplement.
This is why our formula does not contain "supraphysiological" doses, which some people call "megadoses", thus respecting all French MDIs. It has been recognized that, at short and long-term physiological doses, taking multivitamins (of guaranteed quality!) does not present any danger and would even make it possible to limit the differences in micronutrients that grow over time, and potentially permanently, between our needs and what we consume . Multivitamin supplementation could even be an asset in preventing the risk of the appearance and recurrence of long-term cellular degeneration .
- Shenkin, A. Micronutrients in health and disease. Postgrad. Med. J. 2006, 82, 559–567.
- Holt, P.R. Intestinal Malabsorption in the Elderly. Dig. Dis. 2007, 25, 144–150.
- Basu, T.K.; Donaldson, D. Intestinal absorption in health and disease: micronutrients. Best Pract. Res. Clin. Gastroenterol. 2003, 17, 957–979.
- Popkin, B.M. Nutrition Transition and the Global Diabetes Epidemic. Curr. Diab. Rep. 2015, 15, 64.
- Popkin, B.M. Relationship between shifts in food system dynamics and acceleration of the global nutrition transition. Nutr. Rev. 2017, 75, 73–82.
- FAO INFLUENCING FOOD ENVIRONMENTS FOR HEALTHY DIETS; 2016; p. 154;.
- Khammissa, R.A.G.; Fourie, J.; Motswaledi, M.H.; Ballyram, R.; Lemmer, J.; Feller, L. The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health. BioMed Res. Int. 2018, 2018, 1–9.
- Rein, M.J.; Renouf, M.; Cruz-Hernandez, C.; Actis-Goretta, L.; Thakkar, S.K.; da Silva Pinto, M. Bioavailability of bioactive food compounds: a challenging journey to bioefficacy: Bioavailability of bioactive food compounds. Br. J. Clin. Pharmacol. 2013, 75, 588–602.
- Pietrzik, K.; Bailey, L.; Shane, B. Folic Acid and L-5-Methyltetrahydrofolate: Comparison of Clinical Pharmacokinetics and Pharmacodynamics. Clin. Pharmacokinet. 2010, 49, 535–548.
- Prasad, A.S. Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease. Adv. Nutr. 2013, 4, 176–190.
- Zimmermann, M.B. Iodine Deficiency. Endocr. Rev. 2009, 30, 376–408.
- FIGO Working Group on Good Clinical Practice in Maternal–Fetal Medicine; Di Renzo, G.C.; Fonseca, E.; Gratacos, E.; Hassan, S.; Kurtser, M.; Malone, F.; Nambiar, S.; Nicolaides, K.; Sierra, N.; et al. Good clinical practice advice: Micronutrients in the periconceptional period and pregnancy. Int. J. Gynecol. Obstet. 2019, 144, 317–321.
- Tan, B.L.; Norhaizan, M.E.; Liew, W.-P.-P.; Sulaiman Rahman, H. Antioxidant and Oxidative Stress: A Mutual Interplay in Age-Related Diseases. Front. Pharmacol. 2018, 9, 1162.
- Huskisson, E.; Maggini, S.; Ruf, M. The Role of Vitamins and Minerals in Energy Metabolism and Well-Being. J. Int. Med. Res. 2007, 35, 277–289.
- Gironés-Vilaplana, A.; Villaño, D.; Marhuenda, J.; Moreno, D.A.; García-Viguera, C. Vitamins. In Nutraceutical and Functional Food Components; Elsevier, 2017; pp. 159–201 ISBN 978-0-12-805257-0.
- Bhattacharya, P.T.; Misra, S.R.; Hussain, M. Nutritional Aspects of Essential Trace Elements in Oral Health and Disease: An Extensive Review. Scientifica 2016, 2016, 1–12.
- Biesalski, H.K.; Tinz, J. Multivitamin/mineral supplements: Rationale and safety – A systematic review. Nutrition 2017, 33, 76–82.
- Gaziano, J.M.; Sesso, H.D.; Christen, W.G.; Bubes, V.; Smith, J.P.; MacFadyen, J.; Schvartz, M.; Manson, J.E.; Glynn, R.J.; Buring, J.E. Multivitamins in the Prevention of Cancer in Men: The Physicians’ Health Study II Randomized Controlled Trial. JAMA 2012, 308, 1871.
One year of developpement
We undertook to develop our latest generation multivitamins in September 2017. It is by reviewing the entire scientific literature that we came across coenzyme forms of vitamins, liposomal magnesium, high absorption chromium or the synergistic effects of carotenoids and bio-flavonoids.
Security analysis (click on it)
A question ?Our experts answer all your questions.
Why take a multivitamin and how long does it take?
The idea that "taking vitamins is useless when you eat a balanced diet" is still very widespread in France. However, several studies of national scope (SU.VI.MAX, etc.) have shown that micronutrient deficits affect the entire population with special mention for pregnant women, adolescents and over 50s. Note also that a recent and very serious study due to its unprecedented scale (more than 14,000 subjects) * has shown a positive impact on the health of people consuming a multivitamin daily for 11 years! Even if a one-off treatment remains meaningful during the winter or during a gestation period, long-term daily prevention remains the line that we defend at NUTRI & CO.
*: Gaziano, JM; Sesso, H.D .; Christen, W.G .; Bubes, V .; Smith, J.P .; MacFadyen, J .; Schvartz, M .; Manson, J.E .; Glynn, R.J .; Buring, J.E. Multivitamins in the Prevention of Cancer in Men: The Physicians ’Health Study II Randomized Controlled Trial. JAMA 2012, 308, 1871, doi: 10.1001 / jama.2012.14641
What is a bio-active vitamin?
Most vitamins are not directly usable by the body and must be activated through various stages of processing. Some steps go wrong and lead to an uncertain result. This is for example the case with folic acid (synthetic B9) that the body struggles to metabolize into B9 and whose excess could have an impact on health * Administered in bioactive form, vitamins are such as organization uses them and avoids hazardous processing steps.
*: Kim YI. Folate and Carcinogenesis: Evidence, Mechanisms and Implications. J Nutr Biochem 1999; 10: 66-88. Medline
Is there a risk of overdose with your vitamins
The fear of overdose arises from the statement "100% of NRVs" found in nutritional tables. Some neophytes are therefore afraid of going beyond the limits by adding a multi-vitamin to their diet. However, we must not confuse VNR (Nutritional Reference Values *), which are thresholds below which we are deficient, and DJM (Maximum Daily Doses) which represent the limits not to be exceeded in a supplement to date, the EU has not yet determined an ADI for vitamins and minerals. They are therefore specific to each State. These French thresholds are defined in the order of May 9, 2006. Note, however, that part of them were canceled (vitamins K, B1, B2, B5, B8 and B12) by the decision of the Council of State of April 27, 2011. Most vitamins therefore have no safe limits. Our formula does not contain "megadoses" and respects all French DJMs. It should be noted, however, that case law very often authorizes these thresholds to be exceeded. This is for example the case for the following vitamins:
- Vit D: 2000UI in case law vs. 1000UI in DJM
- Vit B9: 400mcg vs 200mcg (especially following the arrival of folate like Quatrefolic)
- Vit B6: 4mg vs. 2mg (following the arrival of the coenzyme form P'-5-P)
- Vit C: 250mg against 180mg.
*: formerly AJR (Recommended Daily Allowance).
Does your formula contain synthetic vitamins?
Most of the vitamins in our formula are in plant form (A, D, E, etc.), but we do not reject molecular chemistry when it provides a real plus. In reality, synthetic does not necessarily mean artificial. Some human-made vitamins are 100% bio-identical to their natural forms and therefore just as effective *. They therefore have content advantages and are free from extraction solvents.
*: natural and synthetic vitamin C have been shown to have exactly the same level of absorption. Carr AC, Bozonet SM, Vissers MCM. A Randomized Cross-Over Pharmacokinetic Bioavailability Study of Synthetic versus Kiwifruit-Derived Vitamin C. Nutrients. 2013.
Why is calcium missing from your recipe?
There are two reasons for the absence of calcium in our formula:
- Contrary to popular belief, it It is very rare to suffer from calcium deficiency. This mineral is indeed found in abundance in our diet. Today, it is rather the deficiencies in vitamins D and K, the two cofactors of calcium, which are rather singled out when we encounter bone problems.
- Calcium supplementation has not yet proven its effectiveness and could even have a negative impact on the cardiovascular sphere. *
*: MJ Bolland, A. Gray, A. Avenell, GD Gamble, IR Reid. Calcium supplements with or without vitamin D and risk of cardiovascular events: Reanalysis of the Limited Access Women's Health Initiative dataset and meta-analysis. BMJ, 2011; 342 (apr19 1)
Why is iron missing from your recipe?
The routine prescription of iron is not based on tangible clinical results. However, since the publication of an American study in 2011, iron supplementation is no longer unanimous. This study of more than 38,000 women demonstrated a reduction in lifespan in subjects who took the most iron supplements *. Specialists point to the pro-oxidant effect of iron when it is present in too much quantity in the body.
*: Mursu J, Robien K, Harnack LJ, Park K, Jacobs DR Jr. Dietary supplements and mortality rate in older women: the Iowa Women's Health Study. Trainee in ark medicine. 2011 Oct 10; 171 (18): 1625-33
Is beta-carotene dangerous when you smoke?
Many studies have investigated the relationship between β-carotene and cancer risk in smokers, but the results remain controversial. Some have found an increased risk, others have not found a positive relationship between β-carotene and cancer risk in smokers. Moreover, any risk must be considered, but it is important to place oneself in the nutritional conditions observed or imposed in these studies. In fact, in the large landmark studies, the β-carotene supplements imposed were 20 mg per day, or even more, and over several years. The EFSA (“European Food Safety Authority”) ruled in 2012, indicating that exposure to β-carotene, at levels below 15 mg per day, did not present any harmful effects on health. in the general population, with specific reference to smokers. By positioning itself in a context of consumption, in France, the national individual study of food consumption (INCA3, 2017) showed in particular that the average daily intake of β-carotene was 2.7 mg. This highlights a notable difference between these intakes and those that can be predicted in the presence of possible supplementation. As part of our Multi, 800 micrograms or 0.8 mg of beta-carotene are present for 3 capsules. In all cases, therefore, we are far below the dose accepted as safe by the EFSA.
Where do our ingredients come from?
Encapsulation • Lustrel Laboratory Montpellier, France
A benchmark in nutraceutical processing, ISO 22000 and organic certified.
Liposomal Magnesium • Magshape® Microcapsules • Lypotec Barcelona, Spain
Lypotec is an international group born in Barcelona specializing in liposomal forms of minerals for the Cosmetics and Nutraceutical industry.
Vitamin K2 • VitaMK7®Denmark
Kappa bio science laboratory.
Natural vitamin E • Nutrabiol® Madrid, Spain
Vitamin B9 • Quatrefolic® (folate) , Gnosis Milan, Italy
Gnosis implements biotransformation (fermentation) processes to design nutritional assets with the aim of improving human health and well-being.
Zinc Gluconate • Isaltis Lyon, France
Isaltis is a French company specializing in the production and study of highly bioavailable minerals.
Fucus extract titrated in Iodine • Plantex Saint-Michel-sur-Orge, France
Plantex is a French SME recognized worldwide for its expertise in plant extraction.
Selenium • Lynside®
Maisons Alfort, France