• growing (80% of hair at this stage)
• stable (1% of hair at this stage)

So it's perfectly normal to lose hair on a daily basis. Generally, more than 100 hairs lost per day is called alopecia, which is a loss that is too important and therefore causes a visible decrease in the density of the hair.

According to a survey IFOP, 3 French people out of 4, not presenting baldness, declare being confronted with a notable loss of hair. Women are particularly prone to this phenomenon [1].

Le cycle du cheveu

In addition to anti-hair loss treatments or cosmetic care, it is now possible to take care of one's hair through nutricosmetics. And to understand how to act, we must first go back to the natural hair cycle, because that's where it all comes down to [2,3].

i. Hair growth, Anagen phase
This is the crucial phase, it lasts 2 to 6 years. A normal hair consists of 85% of hair in the anagen phase, i.e. in the "growth" phase. Today it is strongly affected by stress and pollution. In the presence of pollution particles, a significant decrease in the beta-catenin protein, responsible for hair growth, is detected. Results ? A weakened anagen phase, dull and less dense hair, and significant hair loss [4]. Indeed, it is from the very beginning of this phase that hair growth is activated and that the hair becomes anchored in its follicle. The follicle is therefore a strategic and key place in the health of the hair.

Given the length of this stage, it is easy to understand that a weakening can have a dramatic effect on the health and appearance of the hair, as it will take several years before there is a "new generation" of growth.

ii. Hair maintenance, Catagen phase
Surprisingly, this is the shortest phase of the cycle, since it lasts only 3 weeks on average. Logically, only 1% of the hair is in this phase. During these 3 weeks, the hair must be stable and strengthened - so as not to move too quickly into the Telogen phase (hair loss).

iii. Hair loss, Telogen phase
This phase lasts 3 to 4 months and is inevitable. It concerns a maximum of 15% of a normal hair. At the end of this phase, the hair falls out, leaving the place to the hair follicle reactivated in the anagen phase. This is the beginning of a new cycle and therefore of a new hair. In normal hair, we lose 50 to 100 hairs per day. A more important hair loss can be a sign of a problem.

To act on the hair growth cycle, the ideal is to aim at the anagen phase, since it is there that the hair is formed and everything is at stake. Nutraceuticals offer the possibility to do just that, thanks to certain ingredients that have proven themselves in clinical trials.

Keranat®: at last a plant-based AND effective approach thanks to millet!

The originality of Keranat® compared to first generation solutions, such as keratin or cysteine, is that it acts on the two crucial phases of the hair cycle: growth and maintenance. In other words, rather than relying entirely on structure (keratin and its precursors such as cysteine), Keranat® provides the foundation: hair growth and its foundations. Moreover, keratin suffers from low bioavailability and is of exclusively animal origin. Whereas millet is bioavailable and 100% vegetable, organic and vegan.

2 clinical studies using Keranat®

Keranat® has been the subject of two well-conducted clinical studies [5,6]. They were carried out on a total of 120 women who observed clear positive effects on their hair. The clinical tests carried out on these women demonstrated the link between their hair:

• A reduction in hair loss,
• An activation of their hair growth,
• And an improvement in the beauty and shine of their hair. < Miliacin, the key molecule of Keranat®, is a key component of the Keranat® hair care system.

  Miliacin from millet is the main molecule that gives Keranat® its activity. Clinical data have shown that it is beneficial in maintaining the natural hair cycle by reinforcing the anagen (growth) phase. In particular, it has been shown to increase the production of growth factors such as IGF1 and therefore of cell proliferation at the level of the hair follicle bulb. These extremely interesting results have been associated with an increase in the thickness of collagen (structural fiber of our body) in the bulb. The results of these trials suggest a real positive effect of Keranat® on hair growth and a better anchoring of the hair at its base.

  A vectorized miliacin, 6 times more effective

  The encapsulation technology patented by our partner Robertet allows our miliacin to have a better bioavailability and therefore a better efficacy. Miliacin is encapsulated in polar lipids extracted from wheat, which also have a function, since they boost the production of collagen, a major constituent of the hair sheath. The hair is thus strengthened during the catagen phase (maintenance).

  The first plant biotin bio

  Biotin, known as the hair vitamin, is now available exclusively in a synthetic form. We have succeeded in finding this vitamin in a natural and organic form, extracted from Basil leaves.

  Publications

  1. Tosti, A.; Piraccini, B.M.; Iorizzo, M.; Voudouris, S. The natural history of androgenetic alopecia Blackwell Publishing,Ltd. J. Cosmet. Dermatol. 2005, 3.
  2. Alonso, L.; Fuchs, E. The hair cycle. J. Cell Sci. 2006, 119, 391–393, doi:10.1242/jcs.02793.
  3. Blume-Peytavi, U.; Tosti, A.; Whithing, D.A.; Trüeb, R. Hair Growth and Disorders; Springer.; 2008; ISBN 978-3-540-46908-7.
  4. Sadick, N.S.; Callender, V.D.; Kircik, L.H.; Kogan, S. New Insight Into the Pathophysiology of Hair Loss Trigger a Paradigm Shift in the Treatment Approach. 2017, 16, 6.
  5. Boisnic, S.; Branchet, M.; Gaillard, E.; Lamour, I. Miliacin Associated with Polar Lipids: Effect on Growth Factors Excretion and Extracellular Matrix of the Dermal Papilla Hair Follicle Model Maintained in Survival Conditions. Hair Ther. Transplant. 2016, 06, doi:10.4172/2167-0951.1000143.
  6. Keophiphath, M.; Courbière, C.; Manzato, L.; Lamour, I.; Gaillard, E. “Miliacin encapsulated by polar lipids stimulates cell proliferation in hair bulb and improves telogen effluvium in women.” J. Cosmet. Dermatol. 2020, 19, 485–493, doi:10.1111/jocd.12998.