- Bone & Immunity
Bioidentical, plant-based Vitamin D
In the form of D3 (cholecalciferol), Vitamin D is far more effective than the D2 form (ergocalciferol). Although it is essentially present in the animal kingdom and often extracted from sheep's wool, Lichen Boréal is one of the rare exceptions to the rule and allows us to offer you a 100% vegetable vitamin.
Highly assimilable form
As a fat-soluble vitamin, our D3 is integrated into organic rapeseed oil for optimal absorption.
A dosage for small and large children
Vitamin D3 is a popular player for its role in immune health and bone growth. A dosage adaptable to 1000 IU/drop allows to adapt our bottle to the whole family, from 4 years old !
The benefits of vitamin D are numerous.
This one :
- Contributes to the normal functioning of children's immune system,
- Contributes to the maintenance of normal bone structure,
- Plays a role in the process of cell division,
- Contributes to the maintenance of normal dentition,
- Contributes to the normal absorption and utilization of calcium and phosphorus,
- Contributes to the maintenance of normal muscle function,
- Contributes to normal immune system function,
- Necessary for normal bone growth and development in children.
When to take Vitamin D3?
- Vitamin D3 should be taken with breakfast.
How many drops?
- Children: 1 drop per day.
- Adolescents: 1 to 2 drops per day.
- Adults: 1 to 2 drops per day.
- Pregnant and lactating women: 2 drops per day. day.
- Athletes: 2 drops per day.
- Seniors: 2 drops, all during the year.
Duration of a take
- Take all year round, especially during periods of low sunshine.
How to take your drops?
- The drops are to be taken directly on the tongue or in a spoon, or added to a cold drink.
Duration of a bottle
- The vial of vitamin D lasts 5 months.
Precautions for use
- Food supplement based on vitamin D, to be used in addition to a healthy and balanced diet.
- Do not exceed the recommended daily doses.
- Pregnant and breastfeeding women should seek medical advice before any supplementation .
- Not suitable for children under 4 years old.
- Store in a dry place away from light and heat.
- Keep out of the reach of children.
Ingredients For 1 drop NRV* Vitamin D3 (Cholecalciferol) from Lichen 1000 UI or 25 μg 500% Organic virgin rapeseed oik (Brassica napus L) 39,2 mg
*Nutritional Reference Values
Ingredients : Virgin rapeseed oik*, vegetable Vitamin D3 from lichen, antioxidant : Vitamin E. *ingredients from organic farming. Contains 96% ingredients from organic farming, FR-BIO-01
Vitamin D, which is ?
Vitamin D is vital for bone health by stimulating the absorption and metabolism of calcium and phosphorus. The earliest established role of vitamin D was in the absorption of calcium from the intestine and therefore in the mineralisation and remodelling of bone. During the years of research on vitamin D, its functions have been greatly expanded to include the regulation of metabolism, cell proliferation and differentiation. This vitamin belongs to the class of fat-soluble vitamins and has a hormonal action. There are two forms of vitamin D: vitamin D2 or ergocalciferol and vitamin D3 or cholecalciferol. Vitamin D3 is synthesised in the skin after exposure to sunlight and can be consumed via (mainly) animal food sources, while the D2 form is the synthetic form often found in vitamin D-fortified food products and is derived from plants [1,2]. In summary :
- Natural vitamin D2 of plant origin is synthesised from ergosterol (provitamin D): ergocalciferol is therefore of exogenous origin only,
- Natural vitamin D3, mainly of animal origin, is synthesised in the epidermis and dermis under the action of the sun: cholecalciferol is therefore of endogenous and exogenous origin.
The highest amounts of vitamin D are found in foods of animal origin and specifically in marine products (see table on the amount of vitamin D (μg) per 100g of food consumed; the nutritional composition of foods can be consulted on the website of the ANSES - Agence nationale de sécurité sanitaire de l'alimentation, l'environnement et du travail :https://www.anses.fr/fr/content/la-table-de-composition-nutritionnelle-du-ciqual).
Food Vitamin D quantity(μg/100g) Cod liver oil 250 Canned cod liver 54 Smoked herring ≈20 Grilled Mackerel and Sardine 12 Steamed or raw salmon ≈9 Vegetable fat such as margarine ≈7,5 Dried mushrooms (shiitake type) 4
The market for vitamin D food supplements is substantial: oily capsules, drops, capsules, gummies... The most widespread origin is lanolin: a fat (sometimes called "wax") derived from sheep's wool. Today, even if sources are rare, there are also alternative sources, of vegetable origin and in the form of vitamin D3.
Why vitamin D is essential to our health ?
As mentioned above, vitamin D is essential for bone health. But its roles go beyond that [3-6]:
- Involvement in the expression of numerous genes of our metabolism,
- Participation in the activity of our immune system,
- Primordial to growth and development during life in utero and childhood,
- Protection against the risk of developing chronic diseases (obesity, type II diabetes, cancer...). A meta-analysis has reported that vitamin D supplementation reduces the risk of mortality ,
- Implication in physical performance. Recent evidence suggests that vitamin D supplementation to ensure coverage may be beneficial in improving physical performance [8,9].
The literature on supplementation has increased steadily over the last 10 years. It is thanks to this work that the importance of vitamin D and the coverage of its needs in populations has been demonstrated, particularly in terms of its beneficial role in extra bone-related health .
While supplementation is needed as a comprehensive health prevention strategy for the general population, for some populations more susceptible to impairment it seems to be absolutely essential. For example, it would significantly prevent the risk of falls and fractures in people with osteoporosis . Finally, it ensures optimal child growth during pregnancy and childhood to combat developmental delays and disturbances .
Where to find vitamin D ?
As stated above, vitamin D in humans comes mainly from exposure to sunlight. After exposure to the sun, UVB radiation photolyses (decomposition by light) the "7-dehydrocholesterol" (7-DHC) stored in the epidermis as pre-vitamin D3. Once the latter has been formed, it undergoes a thermal transformation to form vitamin D3, which joins the bloodstream. On the other hand, when exposure to sunlight is too great, pre-vitamin D3 is transformed into inactive vitamin D products. When we consume vitamin D, in the form of D2 or D3, it reaches the intestinal tract and joins the bloodstream. These two forms of vitamin D, D3 (from sunlight and food) and D2 (from food) are converted in the liver to a form of vitamin D3: calcidiol (25(OH)D). And it is in this form that vitamin D is referred to as a prohormone (which is an inactive hormonal form). It is then in the kidneys that calcidiol is transformed into calcitriol (1,25(OH)2D). It is in this form of calcitriol that vitamin D becomes an active hormone, known as steroid hormone. In this form, it exerts its best known role on bone metabolism. It has what is known as hypercalcemic and hyperphosphatemic activity. That is to say, it stimulates the absorption of calcium and phosphorus in the intestine, contributing to the bone mineralisation mechanism (synthesis of bone compounds, particularly collagen). Calcitriol works in conjunction with a hormone with the same activity that you may be familiar with, parathormone [6,13,14].
(Adapted from )
Image digestive anatomy: "Servier medical art"
Why supplement with vitamin D? ?
Despite the solar and dietary origin of vitamin D, many populations have a deficiency status. In women, as bone status is highly engaged over time due to the hormonal variations that take place, vitamin D status via a plasma calcidiol (25(OH)D) assay is achieved more automatically. Vitamin D deficiency can indeed be measured by a blood test. Reference values vary between different health authorities in different countries to determine deficiency or insufficiency status . The reported reference values for plasma vitamin D status are as follows [8,16]:
Status Plasma level (nnmol/l) Plasma level (ng/ml) Severe deficiency <25-30 <10-12 Disability/insufficiency 30-50 12-25 Adecuate rate 50 20 Rates to limit the risk of fracture 75 30 Toxicité >125 >50
The reasons for vitamin D deficiency are diverse and additional [5,13] :
- As we have seen, very few foods naturally contain significant amounts of vitamin D,
- Sunshine varies significantly according to the season (the winter season would represent a period of zero synthesis of vitamin D via the epidermis) which also implies variations according to the geographical area,
- Although vitamin D can be stored in fat (++) and muscle (+), stocks are limited and cannot meet the needs during periods of no sunshine,
- Our lifestyles (sedentary, no consumption of vitamin D containing products, immediate protection from the sun's rays...), health status (significantly overweight, ageing, ...), ethnicity...
For these reasons we understand why vitamin D deficiency is common in the general population and therefore there are several reasons for taking a vitamin D supplement.
In addition, the European Food Safety Authority (EFSA) has set Nutrient Reference Values (NRVs) for vitamin D for different age groups as assessed at 15μg/day or 600 IU/day for an adult . On the other hand, the analysis of several studies shows that these NRVs do not cover all needs and, above all, do not take into account the variability that exists according to an individual's lifestyle and state of health. The conclusions of this analysis of 8 clinical studies on subjects over 40 years of age showed that the coverage of needs could be equivalent to approximately 50 μg per day, i.e. 2000 IU per day [18,19]. It has also been reported that the bio-effectiveness of vitamin D3 is much greater than D2 and therefore vitamin D3 should only be offered as a D3 form of supplementation .
- Zhang, R.; Naughton, D.P. Vitamin D in health and disease: Current perspectives. Nutr. J. 2010, 9, 65, doi:10.1186/1475-2891-9-65.
- Souberbielle, J.-C.; Maruani, G.; Courbebaisse, M. Vitamine D : métabolisme et évaluation des réserves. Presse Médicale 2013, 42, 1343–1350, doi:10.1016/j.lpm.2013.07.010.
- Wang, S. Epidemiology of vitamin D in health and disease. Nutr. Res. Rev. 2009, 22, 188–203, doi:10.1017/S0954422409990151.
- Hossein-nezhad, A.; Holick, M.F. Vitamin D for Health: A Global Perspective. Mayo Clin. Proc. 2013, 88, 720–755, doi:10.1016/j.mayocp.2013.05.011.
- Meehan, M.; Penckofer, S. The Role of Vitamin D in the Aging Adult. J. Aging Gerontol. 2014, 2, 60–71, doi:10.12974/2309-6128.2014.02.02.1.
- Jorge, C. Vitamin D – new insights into an old molecule. Port. J. Nephrol. Hypertens. 2019, 33, doi:10.32932/pjnh.2019.10.033.
- Autier, P.; Gandini, S. Vitamin D Supplementation and Total Mortality. ARCH INTERN MED 2007, 167, 8.
- de la Puente Yagüe, M.; Collado Yurrita, L.; Ciudad Cabañas, M.J.; Cuadrado Cenzual, M.A. Role of Vitamin D in Athletes and Their Performance: Current Concepts and New Trends. Nutrients 2020, 12, 579, doi:10.3390/nu12020579.
- Wiciński, M.; Adamkiewicz, D.; Adamkiewicz, M.; Śniegocki, M.; Podhorecka, M.; Szychta, P.; Malinowski, B. Impact of Vitamin D on Physical Efficiency and Exercise Performance—A Review. Nutrients 2019, 11, 2826, doi:10.3390/nu11112826.
- Scragg, R. Emerging Evidence of Thresholds for Beneficial Effects from Vitamin D Supplementation. Nutrients 2018, 10, 561, doi:10.3390/nu10050561.
- van den Bergh, J.P.W.; Bours, S.P.G.; van Geel, T.A.C.M.; Geusens, P.P. Optimal Use of Vitamin D When Treating Osteoporosis. Curr. Osteoporos. Rep. 2011, 9, 36–42, doi:10.1007/s11914-010-0041-0.
- Hollis, B.W.; Wagner, C.L. New insights into the vitamin D requirements during pregnancy. Bone Res. 2017, 5, 17030, doi:10.1038/boneres.2017.30.
- Holick, M.F. Vitamin D Deficiency. N ENG J MED 2007, 357, 266–277.
- Landrier, J.-F. Vitamine D : sources, métabolisme et mécanismes d’action. Cah. Nutr. Diététique 2014, 49, 245–251, doi:10.1016/j.cnd.2014.07.008.
- HAS Vitamine D_Note de cadrage_Utilité clinique du dosage de la vitamine D; 2013; p. 42;.
- Basit, S. Vitamin D in health and disease: a literature review. Br. J. Biomed. Sci. 2013, 70, 161–172, doi:10.1080/09674845.2013.11669951.
- EFSA Dietary reference values for vitamin D; 2016; p. 145;.
- Heaney, R.P.; Armas, L.A.G.; French, C. All-Source Basal Vitamin D Inputs Are Greater Than Previously Thought and Cutaneous Inputs Are Smaller. J. Nutr. 2013, 143, 571–575, doi:10.3945/jn.112.168641.
- Holick, M.F.; Binkley, N.C.; Bischoff-Ferrari, H.A.; Gordon, C.M.; Hanley, D.A.; Heaney, R.P.; Murad, M.H.; Weaver, C.M. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab. 2011, 96, 1911–1930, doi:10.1210/jc.2011-0385.
- Mistretta, V.I.; Delanaye, P.; Chapelle, J.-P.; Souberbielle, J.-C.; Cavalier, É. Vitamine D2 ou vitamine D3 ? Rev. Médecine Interne 2008, 29, 815–820, doi:10.1016/j.revmed.2008.03.003.
A question ?Our experts answer all your questions.
Does your mixture contain sheep lanolin?
No! Lanolin is extracted from sheep's wool and is a prime source for vitamin D3. However, we wanted to have a Vegan product, so we turned to Boreal Lichen, a fungus from which vitamin D3 can be extracted.
What if I take more than 2 drops?
We recommend that you strictly adhere to the recommended dosage. One or two drops can be taken directly or in a spoon (or in a yoghurt or glass of water). However, if you accidentally take more than the recommended dose, don't panic! Vitamin D is stored by the body and you can, for example, take a break from taking it for a few days before starting again.
Why 500% of NRV ?
Analysis of several studies has shown that European NRVs would not be sufficient to cover vitamin D requirements because they would not take into account differences in an individual's lifestyle and health status. The assessment based on 8 clinical studies is in favour of needs equivalent to 2000 IU per day.
Can I combine this product with your Multi?
Absolutely! 3 capsules of Multi provide 1000 IU, combining with one drop of vitamin D3 per day you reach 2000 IU - the recommended daily dose.
How do I determine my vitamin D status?
The report of the High Authority for Health states that the vitamin D status can only be valid when the dosage is that of the 25(OH)D form ( = 25 OH hydrocholecalciferol, the monohydroxylated form of vitamin D3). The dosage of this form is the only one that makes it possible to assess the body's stocks and therefore the vitamin D status. This dosage is carried out simply by taking a blood sample.
Isn't vitamin D a medicine?
Yes, but not only that! Depending on the dosage, Vitamin D3 is offered in the form of a medicine, such as the famous Uveda or ZymaD, prescribed to newborns and children. It can be dosed up to 100,000 IU per annual intake. But vitamin D without a prescription also exists under the regulatory status of a dietary supplement, with a lower dosage and daily intake.
Should calcium and vitamin K be taken with vitamin D?
Several scientific works have shown a synergistic effect between vitamin D and vitamin K on the increase in total bone mineral density and the decrease in calcification at ship level . On the other hand, vitamin K supplementation is not recommended in certain settings (people on anticoagulants, children, etc.), yet our vitamin D has been designed to be universal and family-friendly. However, it can be combined with the Multi which contains vitamin K2. As for calcium, it is very rare to suffer from a deficiency as Western diets are so full of it. To date, its supplementation has not proven its effectiveness and at high doses could even have a negative impact on the cardiovascular sphere . You will understand, it is therefore more interesting to supplement with calcium cofactors (vitamin D3 and K2) than with calcium itself.
Where do our ingredients come from?
Vegetable Vitamin D3 - VitashineOrigin of Boreal Lichen: Irland, Canada, Scandinavia - Extraction: Nottingham, United Kingdom
Vitashine is the reference producer of vegetable vitamin D3 thanks to its patented and unique process
Organic Rapeseed oil - Huile CauvinOrigin of rapeseed: Italiy and Roumania - Extraction: United States
Huile Cauvin is a family business established in the Nîmes region for more than 60 years. It is recognised for its unique expertise in organic vegetable oils.
Mixing and Packaging - PhytéoAouste-sur-Sye, France
Phytéo is part of the Herbarom group, one of the most recognised nutraceutical manufacturers in France, in particular for its specific know-how in liquid forms.