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According to the definition of the WHO (World Health Organization), probiotics are living microorganisms that exert positive effects on health when ingested in sufficient quantity, beyond the traditional nutritional effects. The majority of published scientific studies on the microbiota concern digestive health and immunity, but its links to the brain and in particular its impact on mood, emotions, stress and anxiety are a subject of more research. increasingly important over the past ten years. Several strains have shown interest, but 2 in particular, Lactobacillus reuteri PBS072 and Bifidumbacterium breve BB077, combined in a patented complex under the name SynbÆctive® KeepCalm, are benefiting from promising clinical studies.
With 4 billion CFU* per intake, you will have the right dose for which benefits on stress, mood and sleep have been observed in clinical studies:
Another ingredient completes our SynbÆctive® KeepCalm synergistic formula for global action on stress mechanisms: magnesium, in the form of patented TRAACS bisglycinate for high absorption and perfect digestive tolerance.
*Colony Forming Unit, i.e. the number of bacteria present per dose.
The links between brain and microbiota are increasingly established, to the point that some speak of our intestine as a “second brain”.
Certain species of bacteria, for example, influence our appetite. Other species would have an effect on our cognitive abilities, or play a role in our emotional balance, to the point that some now speak of “psychobiotics”.
Among them, Lactobacillus reuteri PBS072 and Bifidumbacterium breve BB077 are of particular interest on this subject and are already benefiting from several promising clinical studies.
Nutritional value | 2 capsules | % of AR* |
SynbÆctive® KeepCalm : Lactobacillus reuteri PBS072, Bifidobacterium breve BB077 | 4 mds UFC** | - |
Chelated Magnesium Bisglycinate labeled TRAACS® of which Magnesium element |
312,5 mg 56,3 mg |
- 15 |
* Reference Intakes
**Colony Forming Unit
Ingrédients : Corn starch, TRAACS® labeled magnesium bisglycinate (The Real Amino Acid Chelate System - Albion® Minerals), Gastro-resistant vegetable capsule (gelling agents: hydroxypropylmethylcellulose, pectin), SynbÆctive® KeepCalm patented probiotic complex (Lactobacillus reuteri PBS072, Bifidobacterium breve BB077).
SynbÆctive® is a registered trademark of SYNBALANCE.
Intestinal flora, microbiota, probiotics… These are terms that we have heard more and more often in recent years but whose meaning we do not always know. A microbiota actually refers to all the microorganisms living in a given ecosystem. We have many different microbiota within our body: on the skin, in the digestive system, the vagina, the oral mucosa, saliva or even the nasal mucosa. The microbiome designates all of these different microbiota within the same individual. They contain not only bacteria, but also other microorganisms (archaea, microfungi, viruses). A microbiota is unique to each individual, like a fingerprint, forged by many factors during life such as breastfeeding, diet and taking certain medications.
In the digestive system, the majority of microorganisms, of which bacteria represent the essential, are found in the colon. Indeed, the stomach is too acidic for the development of bacteria, and the small intestine also contains very little.
The main families of bacteria are bifidobacteria, which represent the bulk of the microbiota in the first years of life, as well as lactobacillus, firmicutes, actinobacteria and proteobacteria. Many parameters will affect this composition during life [1]: type of birth (vaginal or cesarean), artificial milk or breastfeeding, diet, etc. Once an adult, the microbiota will remain more or less stable for the rest of its life (apart from taking antibiotics). Food will still be the main criterion that can affect the number and diversity of bacteria in the intestinal microbiota.
The concept of the gut influencing the brain and behavior, and vice versa, has long been known from the digestion angle, with the ability of stress to disrupt digestive functions. With phrases like “feeling it in your gut” or “having butterflies in your stomach,” this gut-emotion connection has long been a part of popular culture. Despite everything, it is only very recently that scientists have developed tools to observe this two-way communication between the brain and the intestine.
This complex gut-brain communication not only ensures the mechanisms of gastrointestinal functions, but also allows the sending of signals through the intestine which will have profound effects on mood, motivation, behavior and cognitive functions. This link passes through the nervous system, in particular the vagus nerve, neuroendocrine cells, activation of the immune system, modulation of enteric reflexes (autonomic nervous system) and signals from enteroendocrine cells (specific cells of the digestive tract and the pancreas). [2-4]
Over the past ten years, research has shown that the intestinal microbiota is a key regulator of this gut-brain axis. For example, exposure to even short-term stress can impact the profile of the microbiota by altering the proportions of different genera, and experimental modulation of the microbiota influences responses to stress, anxiety and the level of triggering of the HPA (hypothalamic-pituitary-adrenal) axis, which plays a central role in the stress response, in particular by reducing cortisol. [5-7]
Even if all the mechanisms are not yet understood, researchers have a global vision of the different pathways of this communication (figure 1). First, bacteria send signals via their structural molecules (pieces of cell wall, etc.). They also produce a large number of metabolites, such as short-chain fatty acids (butyrate), amino acid derivatives (phenolic compounds and ammonia), bile salt metabolites or even secondary metabolites produced from organic compounds derived from food (polyphenols, etc.); In certain cases, we even find molecules acting as neurotransmitters (e.g. acetylcholine). Some of these molecules can be absorbed by the intestinal wall and end up in the circulation, where they can then cross the blood-brain barrier and have an action in the brain.
Another pathway is the activation of the parasympathetic nervous system, via the vagus nerve, and the enteric nervous system, which controls the digestive system. Finally, the microbiota can also activate the immune system, thus influencing the balance of pro- and anti-inflammatory cytokines which directly affect cognitive functions, or triggering the production of neuropeptides by enteroendocrine cells present in the intestinal epithelium. . [7]
Although the majority of work on the effects of the microbiota on stress has been carried out on animals, the number of clinical studies on humans continues to grow. An interesting example is a 2011 study which first observed the anxiolytic effects of 2 strains in rats (L. helveticus R0052 and B. longum R0175), before confirming the effects of these probiotics on reducing stress and anxiety in humans in a clinical study. In the latter, 55 healthy adults took either 3 billion CFU* per day of this complex, or a placebo, for one month. The probiotic group saw an improvement in their stress, anxiety and depression scores. [9] Other studies using different strains of probiotics have also shown positive effects on mood disorders. [10,11]
*CFU: Colony Forming Units, the unit of measurement to quantify the number of living bacteria in a given volume
Finally, a very recent study was conducted on young mothers to observe the effects on postpartum stress. The "baby blues" and postpartum depression are realities for many young mothers, which can also negatively impact babies' early development. 190 women in their first trimester postpartum were divided into 2 groups taking either a multivitamin and the probiotic complex or the multivitamin alone for 90 days. Results: taking the probiotic complex led to a decrease in anxiety and postpartum depression scores, an improvement in the quality of breastfeeding, and even a decrease in crying and restlessness in breastfed babies. [14]
To help you benefit from all these benefits on your microbiota and on managing your stress! Our formula brings together 3 elements:
Les probiotiques sont beaucoup plus sensibles à l’humidité qu’à la température, or les réfrigérateurs ont tendance à créer de la condensation sur les packaging (l’exemple d’une bouteille d’eau est flagrant). Notre formule Probiotique stress et son magnésium est parfaitement stable à température ambiante, évitez donc de la stocker au frigo.
Il est important de comprendre qu’en matière de probiotiques, les résultats sont fonction du microbiote de l’hôte. Chacun réagira différemment. La prise de SynbÆctive® KeepCalm a montré des bienfaits sur la gestion du stress et le sommeil au bout d’un mois dans 2 études cliniques.
Oui, vous pouvez prendre les deux formules en même temps car elles ne contiennent pas les mêmes souches. Ce duo sera d’un grand intérêt en particulier pour votre santé digestive globale.
Les plantes adaptogènes, en particulier la rhodiola et l’ashwagandha, contiennent effectivement des actifs qui ont montré une réelle efficacité pour lutter contre les effets du stress. Mais le microbiote a une action particulière, avec la capacité de communiquer avec le cerveau via des voies qui lui sont propres, ce qui permet une action complémentaire et en profondeur. Pour les personnes les plus sujettes au stress, la prise du Probiotique stress et son magnésium et de notre Rhodiola Bio permettra une synergie d’actions très efficace.
Oui, nos gélules végétales sont gastro-résistantes, afin de préserver les bactéries de l’acidité de l’estomac et de garantir leur arrivée jusqu’au côlon, lieu du microbiote intestinal, où elles pourront développer leur action.
Vous pouvez naturellement acheter notre Probiotique stress et son magnésium au meilleur prix directement depuis notre site Internet. Vous pouvez également acheter notre complément alimentaire probiotique en pharmacie au prix identique (sans ordonnance) et dans certaines enseignes spécialisées.
EXDEN est un laboratoire français spécialiste des compléments alimentaires à base de probiotiques.
SynBalance est une société de biotechnologie leader dans le domaine du développement et de la production de probiotiques de haute qualité.
Albion Minerals est le pionnier mondial en production de minéraux chélatés. Leurs chélates sont produits via des procédés de fermentation non polluants de dernière génération.