Lactobacillus Gasseri

• Helps to promote thinning.
• Helps promote thinning programs.
• Contributes to body weight control.
• Helps to burn fat.

The benefits of Lactobacillus gasseri

The links between obesity and microbiota are increasingly established, as people with obesity have on average a different composition of their microbiota than people of normal weight. Some species of bacteria would affect our metabolism by making us absorb more or less calories. Other species have an effect on our brain and play a role in our appetite and satiety, increasing or decreasing the calories we eat. Among them, the species Lactobacillus gasseri is of particular interest on this subject and already benefits from several promising clinical studies.

When to take our Lactobacillus gasseri and its cola nut?

• Our formula Lactobacillus gasseri and its cola nut must be taken at breakfast.
• If taking Lactobacillus gasseri and its cola nut is associated with antibiotic treatment, it is best to take the capsules about 3 hours after taking the treatment.

How many capsules ?

• Children: Not recommended
• Adolescent: Not recommended.
• Pregnant women: Not recommended.
• Breastfeeding women: seek advice from a health professional before any supplementation
• Adults: Take 2 capsules per day

Duration of a take

• The box of our Lactobacillus gasseri and its cola nut lasts 1 month, at a rate of 2 capsules per day. The intake should last 3 months to comply with clinical studies, or three vials.  

How to take our Lactobacillus gasseri and its cola nut

• Capsules are to be taken with a large glass of water, simply.

What is the microbiota?

A microbiota refers to all microorganisms living in a given ecosystem. We have different microbiota in and on our body: on the skin, in the digestive system, vagina, oral mucosa, saliva or nasal mucosa. The microbiome is all of these different microbiota within an individual. They contain bacteria, but also other microorganisms such as archaea, microchamnabes (mycobiota [1]) and even viruses (viroma [2][3]).

A microbiota is specific and unique to each individual, resulting from many life factors such as breastfeeding, diet and taking certain medications.

The intestinal microbiota: hidden side of your health

In the digestive system, the acid medium of the stomach prevents the development of bacteria, and the small intestine remains quite poor, except when approaching the colon. It is therefore the latter that contains the majority of microorganisms in the entire digestive system, of which bacteria make up the vast majority.

The main families of bacteria are bifidobacteria, which dominate the early years of life, firmicutes, actinobacterials and proteobacteria. From birth, many parameters will influence this composition [4] (see Figure 1): birth by low birth or caesarean section, breastfeeding or artificial milk, food diversification, etc. Each individual then reaches a point of equilibrium in adulthood, and its microbiota will remain more or less stable for the majority of its life, with a unique composition like a fingerprint, even if we find the same species of bases between individuals. Over the course of life, diet will be the main factor influencing the number and diversity of bacteria in the intestinal microbiota.

Figure 1: Evolution of the human intestinal microbiota over the course of life and disturbances. [4]

Why should you take care of your microbiota?

Its activity is fundamental to our health. The most obvious effect is on digestive health. For example, taking probiotics can reduce the side effects of taking antibiotics, including diarrhea, which is one of the most common [5]. They may also reduce some symptoms of irritable bowel syndrome (IBS), especially for people taking a probiotic with several strains for at least 8 weeks [6].

Obesity is also linked to the health of the microbiota, as people with obesity have on average a different microbiota composition than people of normal weight [7]. Some species of bacteria would affect our metabolism by making us absorb more or less calories [8]. Other species would affect our brains [9] and play a role in our appetite and satiety, making us more or less eat [10]. People with metabolic syndrome may also benefit from probiotics and symbiotics, with several studies showing a decrease in total cholesterol with supplementation [11].

Finally, the microbiota has an important influence on our immune system, as many studies have shown a reduced risk of respiratory infection with probiotics [12] [13].

Dysbiosis: when your microbiota is no longer on its plate

Frequently, our microbiota is unbalanced, with changes in its composition and metabolic activity: this is called dysbiosis. An unbalanced diet, rich in sugar and refined carbohydrates, and the use of certain drugs, such as antibiotics, are the main sources of dysbiosis.

Dysbiosis can promote many health problems, ranging from simple symptoms such as fatigue, to digestive problems such as irritable bowel syndrome, celiac disease (gluten intolerance), allergies or may even help to promote chronic inflammation, with all the adverse health effects that chronic inflammation can cause.

Probiotics, the bacteria that want us good

Probiotics, as defined by the WHO, are living microorganisms that, if administered in an adequate amount, can have positive effects on the health of the host [14] [15] [16] [17] [18]. To put it simply, these are bacteria, whose strains are already found in the intestinal microbiota, but which will also be found in fermented foods and in specific supplements. The best known food product rich in probiotics is yogurt, milk fermented using 2 specific species of bacteria, Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus. Kimchi, sauerkraut and kefir are also foods containing probiotics. The most studied probiotics you will find most commonly belong to two genera: Bifidobacterium spp. and Lactobacillus spp.

Zoom on Lactobacillus gasseri : THE slimming probiotic

Among these numerous bacteria, one species has been of particular interest to researchers for several years for its effects on weight management: Lactobacillus gasseri.

As summarized in a systematic review, studies using Lactobacillus gasseri have observed a decrease in Body Mass Index, waist circumference and visceral fat. Visceral fats are associated with an increased risk of insulin resistance and other metabolic disorders. For example, supplementation with Lactobacillus gasseri BRN17 prevented the increase of adipose tissue in rats fed a very high carbohydrate diet. Another strain, Lactobacillus gasseri SBT2055 also promoted weight loss and fat loss. It seems that Lactobacillus gasseri prevents the increase of adipocytes, certainly through the suppression of the expression of a lipogen gene. [19]

Looking in detail at the clinical studies, a Korean double-blind, placebo-randomized study tested overweight or obese adults with Lactobacillus gasseri BNR17, a variety derived from breast milk.  They took either a placebo or 1 billion CFU (low dose) or 10 billion CFU (high dose) for 12 weeks. Visceral adipose tissue was significantly decreased in the high-dose group compared to placebo. Waist circumference had been reduced in both groups taking L. gasseri. [20]

In another study, Japanese researchers this time used the variety Lactobacillus gasseri SBT2055 incorporated in fermented milk in healthy adults with a large visceral fat mass. The results show that even a small amount of bacteria (100 million CFU per day) has the ability to reduce visceral fat. It is interesting to note that these effects fade a few weeks after stopping supplementation, indicating the need for longer-term intake to preserve benefits. [21]

An animal model study gives us possible mechanisms of action. Mice were fed different feeding patterns (normal, high in sugar and high in sugar + Lactobacillus gasseri BNR17 supplementation at 1 billion or 100 million CFU/day) for 10 weeks. Both groups taking L. gasseri had lower levels of plasma leptin, suggesting that the reduction in fat and weight is associated with a decrease in leptin in serum. In this study, taking L. gasseri also significantly increased the expression of the GLUT4 gene in adipose tissue. This gene allows greater sensitivity to insulin and thus reduces the risk of insulin resistance. [22]

But the health benefits of Lactobacillus gasseri are not limited to weight loss! Preclinical data suggest positive effects on immunity, against vaginal infections, in ulcer control and against infection by the bacterium Helicobacter pylori (stomacal sphere), on irritable bowel syndrome and in improving diarrhea. [23]

Why buy our food supplement Lactobacillus gasseri and its cola nut? 

To make you enjoy all these benefits, our formula brings together 4 elements:

• A clinically validated dosage: with 12 billion CFU per intake, you will have the right dose for which weight and fat benefits have been studied. Far from products that are too low in dosage or those that race for useless megadoses !
• Gastro-resistant capsules: to guarantee the action of the formula, our capsules are coated with a gastro-resistant envelope to prevent them from dissolving in the stomach. They will thus reach their place of action: the intestinal microbiota present in the colon.
• Cola nuts in synergy: Cola nuts are known for their overall slimming action. It helps to promote thinning, burn fat and helps control weight.
• Vitamin B2 for digestive health: riboflavin helps maintain normal mucous membranes.

Références

1. Botterel F, Angebault C, Bougnoux ME. Le mycobiome humain : actualités et perspectives. Revue Francophone des Laboratoires. Volume 2015, Issue 469, pages 67-73. doi : 10.1016/S1773-035X(15)72823-6
   
2. Zuo T, Lu XJ, Zhang Y, et al. Gut mucosal virome alterations in ulcerative colitis. Gut. 2019;68(7):1169-1179. doi:10.1136/gutjnl-2018-318131
3. Mukhopadhya I, Segal JP, Carding SR, Hart AL, Hold GL. The gut virome: the 'missing link' between gut bacteria and host immunity?. Therap Adv Gastroenterol. 2019;12:1756284819836620. Published 2019 Mar 25. doi:10.1177/1756284819836620
4. Ottman N, Smidt H, de Vos WM, Belzer C. The function of our microbiota: who is out there and what do they do?. Front Cell Infect Microbiol. 2012;2:104. Published 2012 Aug 9. doi:10.3389/fcimb.2012.00104
5. Blaabjerg S, Artzi DM, Aabenhus R. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients-A Systematic Review and Meta-Analysis. Antibiotics (Basel). 2017;6(4):21. Published 2017 Oct 12. doi:10.3390/antibiotics6040021
6. Dale HF, Rasmussen SH, Asiller ÖÖ, Lied GA. Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review. Nutrients. 2019;11(9):2048. Published 2019 Sep 2. doi:10.3390/nu11092048
7. Davis CD. The Gut Microbiome and Its Role in Obesity. Nutr Today. 2016;51(4):167-174. doi:10.1097/NT.0000000000000167
8. Zhao L. The gut microbiota and obesity: from correlation to causality. Nat Rev Microbiol. 2013;11(9):639-647. doi:10.1038/nrmicro3089
9. Ochoa-Repáraz J, Kasper LH. The Second Brain: Is the Gut Microbiota a Link Between Obesity and Central Nervous System Disorders?. Curr Obes Rep. 2016;5(1):51-64. doi:10.1007/s13679-016-0191-1
10. Morel FB, Dai Q, Ni J, Thomas D, Parnet P, Fança-Berthon P. α-Galacto-oligosaccharides Dose-Dependently Reduce Appetite and Decrease Inflammation in Overweight Adults. J Nutr. 2015;145(9):2052-2059. doi:10.3945/jn.114.204909
11. Hadi A, Arab A, Khalesi S, Rafie N, Kafeshani M, Kazemi M. Effects of probiotic supplementation on anthropometric and metabolic characteristics in adults with metabolic syndrome: A systematic review and meta-analysis of randomized clinical trials. Clin Nutr. 2021;40(7):4662-4673. doi:10.1016/j.clnu.2021.05.027
12. King S, Glanville J, Sanders ME, Fitzgerald A, Varley D. Effectiveness of probiotics on the duration of illness in healthy children and adults who develop common acute respiratory infectious conditions: a systematic review and meta-analysis. Br J Nutr. 2014;112(1):41-54. doi:10.1017/S0007114514000075
13. Ozen M, Kocabas Sandal G, Dinleyici EC. Probiotics for the prevention of pediatric upper respiratory tract infections: a systematic review. Expert Opin Biol Ther. 2015;15(1):9-20. doi:10.1517/14712598.2015.980233
14. Tsai YL, Lin TL, Chang CJ, et al. Probiotics, prebiotics and amelioration of diseases. J Biomed Sci. 2019;26(1):3. Published 2019 Jan 4. doi:10.1186/s12929-018-0493-6
15. Torres S, Fabersani E, Marquez A, Gauffin-Cano P. Adipose tissue inflammation and metabolic syndrome. The proactive role of probiotics. Eur J Nutr. 2019;58(1):27-43. doi:10.1007/s00394-018-1790-2
16. Sanders ME, Merenstein DJ, Reid G, Gibson GR, Rastall RA. Probiotics and prebiotics in intestinal health and disease: from biology to the clinic [published correction appears in Nat Rev Gastroenterol Hepatol. 2019 Aug 9;:]. Nat Rev Gastroenterol Hepatol. 2019;16(10):605-616. doi:10.1038/s41575-019-0173-3
17. Gibson GR, Hutkins R, Sanders ME, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14(8):491-502. doi:10.1038/nrgastro.2017.75
18. Swanson, K.S., et al. (2020) The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nature Reviews Gastroenterology & Hepatology. doi.org/10.1038/s41575-020-0344-2.
19. Crovesy L, Ostrowski M, Ferreira DMTP, Rosado EL, Soares-Mota M. Effect of Lactobacillus on body weight and body fat in overweight subjects: a systematic review of randomized controlled clinical trials. Int J Obes (Lond). 2017;41(11):1607-1614. doi:10.1038/ijo.2017.161
20. Kim J, Yun JM, Kim MK, Kwon O, Cho B. Lactobacillus gasseri BNR17 Supplementation Reduces the Visceral Fat Accumulation and Waist Circumference in Obese Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. J Med Food. 2018;21(5):454-461. doi:10.1089/jmf.2017.3937
21. Kadooka Y, Sato M, Ogawa A, et al. Effect of Lactobacillus gasseri SBT2055 in fermented milk on abdominal adiposity in adults in a randomised controlled trial. Br J Nutr. 2013;110(9):1696-1703. doi:10.1017/S0007114513001037
22. Kang JH, Yun SI, Park MH, Park JH, Jeong SY, Park HO. Anti-obesity effect of Lactobacillus gasseri BNR17 in high-sucrose diet-induced obese mice. PLoS One. 2013;8(1):e54617. doi:10.1371/journal.pone.0054617
23. Selle K, Klaenhammer TR. Genomic and phenotypic evidence for probiotic influences of Lactobacillus gasseri on human health. FEMS Microbiol Rev. 2013;37(6):915-935. doi:10.1111/1574-6976.12021