- Maintenance of mucous
Acid reflux, burning, heartburn... Post-meal sensations that put our stomach to the test. If some solutions of food supplements exist, very few are scientifically objectified. Thanks to Nutraceutics, it is possible to reconcile traditionally recognized natural approaches with clinically validated proof of effectiveness for the comfort and proper functioning of the stomach.
An SOS "band-aid effect" solution
Our formula mimics the effect of usual dressing solutions and goes even further thanks to MucosaveTMFG® , a patented extract of cactus (Opuntia ficus-indica) and olive tree (Olea Europaea) that helps to line the gastric mucosa. Cultivated under the Sicilian sun, these two plants are rich in polysaccharides and polyphenols, which are the source of their benefits for the gastric sphere. Two clinical studies of more than 100 subjects each demonstrated the effectiveness of MucosaveTMFG® on gastric discomfort and acid reflux with a dosage of 400 mg.
And licorice to prevent the harmful effects of ascending
The fast effect is good, but if with each meal, the discomfort returns, it is not terrible! For this, we have selected Gutgard® a patented extract of licorice root, in this case the species Glycyrrhiza glabra, the most scientifically valued on the gastric sphere. Our ingredient Gutgard® is standardized to 10% flavonoids including 1/3 glabridine (a triterpene), its molecule of interest for the maintenance of the mucosa. With a dosage of 150 mg per day, Gutgard® proved its local action via 2 clinical studies (+150 subjects) on Helicobacter pylori bacteria and on dyspepsia. This extract is totally free of glycyrrhizic acid, known for its relationship with blood pressure. In addition, MucosaveTMFG® and a sage extract known for its virtues on the proper functioning of the stomach, participate in a complete preventive action.
Heartburn, acid reflux, dyspepsia, nausea... Our formula targets the various gastric discomforts.
- The licorice Glycyrrhiza glabra holds especially its benefits of the glabridine. Its local antioxidant action makes it an ingredient of choice to preserve the stomach from the discomfort of acid reflux.
- The olive tree (Olea Europaea) and the cactus (Opuntia ficus-indica) present interesting virtues in the care of the gastric discomfort and the acid rise by their contributions in polysaccharides and polyphenols.
- Sage helps to promote digestion and contributes to the normal functioning of the stomach.
- The vitamin B2 contributes to the maintenance of normal mucous membranes.
The benefits of licorice
The notoriety of licorice root, and particularly of the species Glycyrrhiza glabra, is no longer to be demonstrated by its use in traditional Chinese medicine. Its virtues on the gastrointestinal sphere are widely referenced in the literature which highlights the antioxidant properties of the triterpenes and flavonoids it contains. It acts in particular on the production of mucus by the stomach, natural protection against the acidity of gastric secretions. And it makes it possible to limit the adhesion of the Helicobacter pylori bacterium to the stomach wall, thus contributing to reduce the discomfort of the acid rise.
Behind this generic designation are several manifestations of gastric discomfort. The natural acidity of our stomach can cause pain and burning sensations with acid reflux from the stomach into the esophagus. Generally punctual, these gastric refluxes can prove to be pathological in case of weakness of the sphincter, this small muscle supposed to avoid this phenomenon. This is called gastroesophageal reflux. Heaviness, bloating and feelings of overflow can also be felt after meals. The term dyspepsia refers to all these discomforts which can really impact our daily life and each meal. Antacids, gastric dressings or even proton pump inhibitors (PPI)... If these solutions are commonly used, Nutra also has choice active ingredients with clinical evidence of effectiveness.
When to take the Stomach Formula?
Our Stomach Formula can be taken :
- In case of occasional reflux and known reaction to certain foods: take 3 capsules.
- either as prevention, just after the meal and before the onset of reflux
- or as soon as the reflux appears.
- In case of regular, even daily reflux: take 2 to 3 capsules according to the intensity, at the end of the meal that causes the most discomfort. It is possible to spread the 3 capsules over the day: 2 capsules after the meal that causes the most discomfort and 1 capsule after the other meal.
How many capsules?
- Children : Not recommended.
- Adolescents: Not recommended.
- Adults: 2 to 3 capsules per day.
- Pregnant and breastfeeding women: 2 to 3 capsules per day.
The Stomach Formula is suitable for pregnant and nursing women.
Duration of one intake
- The Stomach Formula is taken as needed and can be repeated over 6 weeks. Beyond that, medical advice is recommended.
How to take the Stomach Formula?
- The capsules are to be taken with a large glass of water after the meal.
Duration of a box
- One can of our Stomach Formula lasts approximately 10 days.
Precautions for use
- To be consumed as part of a healthy and balanced diet.
- Do not exceed the recommended daily doses.
- Inform your doctor or pharmacist if you are taking any other medication at the same time.
- Do not use for more than 6 weeks without medical advice.
- Store in a dry place, away from light and heat.
- Keep out of reach of children.
- In case of occasional reflux and known reaction to certain foods: take 3 capsules.
Ingredients (mg) For 2 capsules For 3 capsules % RC*
(For 2 caps)
Sage 334 501 - Cactus and olive tree extract MucosaveTMFG® 266,6 400 - • Including cactus extract 146 219 - • Including olive tree extract 120,6 181 - Gutgard® licorice extract 100 150 - Vitamin B2 0,21 22,4
Ingredients : Sage extract (Salvia officinalis), MucosaveTMFG® : blend of cactus (Opuntia ficus-indica) and olive (Olea Europaea) extracts, Coating agent: hydroxypropylmethylcellulose, Gutgard® : licorice extract (Glycyrrhiza glabra), Bulking agent: acacia fiber, Rice extract, Vitamin B2.
MucosaveTMFG® is a registered trademark of BIONAP.
Gutgard® is a registered trademark of Natural Remedies.
The stomach in the digestion process
Digestion is a chemical process that degrades the food we ingest, but also a mechanical process that grinds and mixes it. Through its stages, digestion involves different organs that receive the food bolus (chewed food from the mouth) such as the stomach, intestines, or parallel organs involved with their secretions such as the pancreas, liver and gallbladder.
Upon arrival of the food bolus, the stomach secretes digestive enzymes and gastric juices. The hydrochloric acid in these juices activates the digestive enzymes that break down the macronutrients in our food. The food bolus spends some time in the stomach (about 3-4 hours) where it is crushed and stirred, and then continues to the small intestine where enzymatic digestion continues.
Stomach function and acid reflux
It is thanks to muscles that the food bowl can progress through the digestive system. But due to a weakness of the sphincter, a muscle located at the junction of the esophagus and the stomach, the stomach can go up towards the esophagus. And because of the acidity contained in the stomach, it is easy to understand the term acid reflux and the unpleasant sensations that result. When they are repeated, these acid refluxes represent a real daily discomfort characterized as gastroesophageal reflux (GERD). It is estimated that 5-10% of adults suffer from GERD .
Acid reflux can also be the consequence of a more important gastro-duodenal damage due to the presence of Helicobacter pylori bacteria. This bacterium, which develops in the stomach, is responsible for a chronic infection of the stomach that is usually acquired during childhood and persists throughout life, resulting in chronic gastric ailments such as ulcers.
Finally, gastroesophageal reflux disease (GERD) can lead to dyspepsia, a digestive disorder characterized by chronic discomfort in the stomach. Dyspepsia is characterized by a feeling of poor digestion, rapid satiety, or stomach pain or heartburn.
Lifestyle and stomach
Stress, diet... If many of our digestive problems result from our lifestyle, other specific conditions such as pregnancy, aging or obesity, also contribute.
In case of acid reflux, recognized hygienic and dietary measures can be implemented to improve digestive well-being  such as
- Avoid eating large, fatty meals,
- Avoid lying down or going to bed right after a meal,
- Manage excess weight,
- Identify foods that exacerbate these disorders due to individual susceptibility: alcohol, fatty foods, juices or excess raw vegetables...
Solutions against acid reflux
In the management of acid reflux and gastroesophageal reflux disease (GERD), proton pump inhibitors (PPIs) [2,3] are widely used. These drugs aim to reduce gastric acid secretion. Without prescription, they are an easy but sometimes inappropriate response and long-term use is not favorable. To date, few alternatives exist on the market .
Before resorting to drug solutions, changes in habits can limit most digestive discomforts such as acid reflux. But it is not always easy to maintain these habits on a daily basis. With its dietary supplements for the stomach, Nutraceutics can provide easy, effective solutions without harmful effects in the long term.
Licorice, ginger, mallow, dandelion, artichoke, sage... Numerous plants are recognized as suitable and effective solutions, and their references in the scientific literature show their proven and targeted benefits on stomach ailments [5-7].
Licorice, Glycyrrhiza sp., is a perennial plant of the Fabaceae family whose rhizome (root) is the part of interest. Its etymology comes from the Greek "glykos" for "sweet" and "Rhiza" for rhizome. The history of licorice and its consumption goes back to Antiquity and can be traced in Southeast Europe (Greece, Rome and Egypt) to Asia. It is one of the most used and prescribed plants in traditional Chinese medicine (9 out of 10 formulas would contain it) for its virtues, especially against inflammation and on the gastrointestinal sphere. Licorice is also widely used in Ayurvedic medicine.
To date, 30 species of licorice have been identified, and among them, three are the most studied for their nutritional and pharmacological potential, and the only ones present in the Chinese pharmacopoeia: Glycyrrhiza glabra, Glycyrrhiza inflata, Glycyrrhiza uralensis.
The European pharmacopoeia also refers to the traditional use of these three species for their benefits in case of stomach-related problems .
Nevertheless, botanical differences (geographical origin, morphology...) between these species exist as well as their profile in compounds of interest which determines, consequently, distinct biological activities and benefits.
Globally, licorice root is widely used throughout the world as an active ingredient in many nutraceutical (in dietary supplements for heartburn and gastroesophageal reflux disease), cosmetic or food formulations . In the form of extracts, in teas, tablets, capsules or in liquid solutions, dry root powder allows a variety of uses. The literature reports that licorice root, at the level of the stomach, protects the mucus cells and promotes the production of mucus. Thus, it would participate in the protection of the natural acidity of the stomach. Licorice root would also fight against the adhesion of the Helicobacter pylori bacteria which can accentuate the discomfort of acid reflux .
The active compounds of licorice [12,14]
For more than 6 decades, licorice has attracted the interest of scientific research. About 300 compounds have been isolated in licorice root, such as terpenes and flavonoids (isoflavones, flavanols, isoflavans, flavanones, coumarins...). Among them, some triterpenes and flavonoids give the plant its biological benefits  .
The species Glycyrrhiza glabra is characterized by a high content of a particular isoflavonoid, glabridine. And it is the presence of this compound, one of the most studied on the digestive sphere , which gives licorice its benefits on digestive comfort at the level of the stomach. In general, Glycyrrhiza glabra is the species most used in licorice-based formulations, notably for its pharmacological activity [17,18].
Licorice is, moreover, very often characterized by a particular compound, glycyrrhizic acid (or glycyrrhizin) of the pentacyclic triterpenoid saponin group. Although it has a recognized pharmacological activity, glycyrrhizic acid is harmful at high doses (hypertension and renal insufficiency). This is why licorice extracts are often purified (they are "deglycyrrhizinated") and why a limit dose has been established for its use in food supplements.
It should be noted that glycyrrhizic acid is referenced as a food additive (sweetener) to improve the organoleptic qualities of the food. Used as a non-sweetening flavoring agent, it gives a composition the sweet flavor of licorice.
The Nutri&Co Stomach Formula
Strength in unity. For our Stomach Formula, which targets acid reflux, heartburn and gastric reflux, we have combined several active plant ingredients from plants with recognized and proven virtues for stomach comfort.
Liquorice, cactus, olive tree and sage compose our 100% natural formula for a complete approach on the gastric sphere by coupling thus specific and prolonged effects.
- A patented licorice extract:
Gutgard® selected licorice extract is an extract standardized in glabridine, the molecule of interest of the Glycyrrhiza glabra species. Its patented extraction process allows it to be free of glycyrrhizinic acid. The efficacy, tolerance and safety of Gutgard® have been demonstrated in 2 clinical studies which show an improvement in stomach-related discomforts including acid reflux:
- A study on 107 subjects  with Helicobacter pylori infection with a dosage of 150 mg over a period of 8 weeks.
- A study on 50 subjects  with dyspepsia with a dosage of 150 mg per day (in one or two doses: 2 x 75 mg) over a period of 30 days.
- A patented cactus and olive extract for acid reflux:
The extract MucosaveTMFG® combines an extract of cactus (Opuntia ficus-indica) source of polysaccharides and an extract of olive tree (Olea Europaea) source of polyphenols. We have selected these 2 extracts manufactured in Sicily for their richness in polysaccharides and polyphenols which are the source of their benefits on the stomach and its ailments.
The efficacy, tolerance and safety of MucosaveTMFG® are supported by 2 clinical studies on acid reflux with a dosage of 400 mg per day on :
- 108 subjects over 8 weeks ,
- 100 subjects over 10 weeks .
- Sage extract:
In the European Pharmacopoeia, sage (Salvia officinalis) is referenced for its use on the stomach sphere . Recognized for its richness in antioxidant polyphenols, sage helps to promote digestion and the proper functioning of the stomach.
- SNFGE Reflux Gastro-Œsophagien (RGO) Available online: https://www.snfge.org/content/reflux-gastro-oesophagien-rgo.
- Reinberg, O. Inhibiteurs de La Pompe à Protons (IPP) : Peut-Être Pas Si Inoffensifs Que Cela. 2015, 11, 1665–1671.
- Lassalle, M.; Le Tri, T.; Bardou, M.; Biour, M.; Kirchgesner, J.; Rouby, F.; Dumarcet, N.; Zureik, M.; Dray-Spira, R. Use of Proton Pump Inhibitors in Adults in France: A Nationwide Drug Utilization Study. Eur. J. Clin. Pharmacol. 2020, 76, 449–457, doi:10.1007/s00228-019-02810-1.
- ANSM Près de 16 Millions de Personnes Ont Eu Une Prescription d’inhibiteurs de La Pompe à Protons (IPP) En 2015 En France Available online: https://ansm.sante.fr/actualites/pres-de-16-millions-de-personnes-ont-eu-une-prescription-dinhibiteurs-de-la-pompe-a-protons-ipp-en-2015-en-france.
- González-Stuart, A.E.; McCallum, R.W. Medicinal Plants Used for Digestive Disorders – What the Gastroenterologist Needs to Know. Pract. Gastroenterol. 2015, 7.
- Gao, X.; Liu, J.; Li, L.; Liu, W.; Sun, M. A Brief Review of Nutraceutical Ingredients in Gastrointestinal Disorders: Evidence and Suggestions. Int. J. Mol. Sci. 2020, 21, 1822, doi:10.3390/ijms21051822.
- Salehi, M.; Karegar-Borzi, H.; Karimi, M.; Rahimi, R. Medicinal Plants for Management of Gastroesophageal Reflux Disease: A Review of Animal and Human Studies. J. Altern. Complement. Med. 2017, 23, 82–95, doi:10.1089/acm.2016.0233.
- Maoyuan, J.; Shengjia, Z.; Shasha, Y.; Xia, L.; Xiguo, H.; Xiguo, H.; Xinyi, W.; Qin, S.; Rui, L.; Chaomei, F.; et al. An “Essential Herbal Medecine”-Licorice : A Review of Phytochemicals and Its Effects in Combination Preparations. J. Ethnopharmacol. 2019.
- Fiore, C.; Eisenhut, M.; Ragazzi, E.; Zanchin, G.; Armanini, D. A History of the Therapeutic Use of Liquorice in Europe. J. Ethnopharmacol. 2005, 99, 317–324, doi:10.1016/j.jep.2005.04.015.
- Liu, H.; Wang, J.; Zhou, W.; Wang, Y.; Yang, L. Systems Approaches and Polypharmacology for Drug Discovery from Herbal Medicines: An Example Using Licorice. J. Ethnopharmacol. 2013, 146, 773–793, doi:10.1016/j.jep.2013.02.004.
- EMA Assessment Report on Glycyrrhiza Glabra L. and/or Glycyrrhiza Inflata Bat. and/or Glycyrrhiza Uralensis Fisch., Radix; 2013;
- Husain, I.; Bala, K.; Khan, I.A.; Khan, S.I. A Review on Phytochemicals, Pharmacological Activities, Drug Interactions, and Associated Toxicities of Licorice ( Glycyrrhiza Sp.). Food Front. 2021, 2, 449–485, doi:10.1002/fft2.110.
- Murray, M.T. Glycyrrhiza Glabra (Licorice). Pharmacol. Nat. Med. 2018, 11.
- Hasan, Md.K.; Ara, I.; Mondal, M.S.A.; Kabir, Y. Phytochemistry, Pharmacological Activity, and Potential Health Benefits of Glycyrrhiza Glabra. Heliyon 2021, 7, e07240, doi:10.1016/j.heliyon.2021.e07240.
- Yang, R.; Yuan, B.-C.; Ma, Y.-S.; Zhou, S.; Liu, Y. The Anti-Inflammatory Activity of Licorice, a Widely Used Chinese Herb. Pharm. Biol. 2017, 55, 5–18, doi:10.1080/13880209.2016.1225775.
- Li, C.; Li, T.; Zhu, M.; Lai, J.; Wu, Z. Pharmacological Properties of Glabridin (a Flavonoid Extracted from Licorice): A Comprehensive Review. J. Funct. Foods 2021, 85, 104638, doi:10.1016/j.jff.2021.104638.
- Pastorino, G.; Cornara, L.; Soares, S.; Rodrigues, F.; Oliveira, M.B.P.P. Liquorice ( Glycyrrhiza Glabra ): A Phytochemical and Pharmacological Review: Liquorice ( Glycyrrhiza Glabra ): A Review. Phytother. Res. 2018, 32, 2323–2339, doi:10.1002/ptr.6178.
- El-Saber Batiha, G.; Magdy Beshbishy, A.; El-Mleeh, A.; M. Abdel-Daim, M.; Prasad Devkota, H. Traditional Uses, Bioactive Chemical Constituents, and Pharmacological and Toxicological Activities of Glycyrrhiza Glabra L. (Fabaceae). Biomolecules 2020, 10, 352, doi:10.3390/biom10030352.
- Puram, S.; Suh, H.C.; Kim, S.U.; Bethapudi, B.; Joseph, J.A.; Agarwal, A.; Kudiganti, V. Effect of GutGard in the Management of Helicobacter Pylori : A Randomized Double Blind Placebo Controlled Study. Evid. Based Complement. Alternat. Med. 2013, 2013, 1–8, doi:10.1155/2013/263805.
- Raveendra, K.R.; Jayachandra; Srinivasa, V.; Sushma, K.R.; Allan, J.J.; Goudar, K.S.; Shivaprasad, H.N.; Venkateshwarlu, K.; Geetharani, P.; Sushma, G.; et al. An Extract of Glycyrrhiza Glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Evid. Based Complement. Alternat. Med. 2012, 2012, 1–9, doi:10.1155/2012/216970.
- Alecci, U.; Bonina, F.; Bonina, A.; Rizza, L.; Inferrera, S.; Mannucci, C.; Calapai, G. Efficacy and Safety of a Natural Remedy for the Treatment of Gastroesophageal Reflux: A Double-Blinded Randomized-Controlled Study. Evid. Based Complement. Alternat. Med. 2016, 2016, 1–8, doi:10.1155/2016/2581461.
- Malfa, G.A.; Di Giacomo, C.; Cardia, L.; Sorbara, E.E.; Mannucci, C.; Calapai, G. A Standardized Extract of Opuntia ficus‐indica (L.) Mill and Olea europaea L. Improves Gastrointestinal Discomfort: A double‐blinded randomized‐controlled Study. Phytother. Res. 2021, 35, 3756–3768, doi:10.1002/ptr.7074.
- EMA Assessment Report on Salvia Officinalis L., Folium and Salvia Officinalis L., Aetheroleum; 2016;
Our promise of transparency also includes the publication of quality analyses:
A question ?Our experts answer all your questions.
Is your formula a gastric bandage?
Our Stomach Formula is not quite a stomach bandage. With or without a prescription, this type of medication targets stomach pain by lining the stomach lining. While our Stomach Formula targets gastric discomfort, it does not work by lining the stomach wall.
Is it indicated against heartburn?
On certain types of burns yes! Burning sensations are often the consequence of gastro-esophageal reflux. In this context, our formula can help to relieve the discomfort. However, it does not act on the origin of the GERD which is related to the anatomy of the stomach and a weakness of the sphincter which lets go up the acidity in the esophagus.
Does the Stomach Formula work on Helicobacter pylori?
Yes, our formula contains a patented licorice extract, Gutgard®, which has been studied for H. pylori infections. And to be certain of an infection due to this bacteria, we recommend that you consult a healthcare professional.
Does your Stomach Formula with licorice make you fat?
No, our formula is not fattening. Our licorice extract contains no sugar and focuses only on molecules of interest for gastric comfort. The sweetness of the raw licorice root is due to the presence of glycyrrhizic acid. This compound is often used in formulations for its sweetening power, but in reality it is a sweetener and is therefore not caloric.
Can you take it continuously or do you have to take breaks?
Any formula containing licorice is recommended for occasional use. Beyond 6 weeks of use, medical advice is recommended. For a daily and prolonged use, we thus invite you to indicate to your doctor that it is about an extract of liquorice without glycyrrhizinic acid dosed at 150 Mg per day for 3 capsules.
Can I take it for dyspepsia?
Yes, dyspepsia is characterized by a feeling of "poor digestion" with pain in the pit of the stomach and bloating. Our Stomach Formula may be indicated under medical advice because it targets stomach discomfort.
Does your licorice extract contain glycyrrhizic acid?
Our licorice extract is free of glycyrrhizic acid. Given the regulations and the literature, we preferred an extract whose patented extraction method allows it to be totally free of it.
Does this formula contain digestive enzymes?
Licorice and the other extracts in our formula do not contain digestive enzymes. If you are looking for a digestive solution based on enzymes, we recommend our Enzymes and Dandelion formula, a mix of 7 enzymes including lactase.
Is it compatible with your other digestion products like Le Détox, Les Fibres and Le Probiotique?
Yes, these 3 formulas are completely compatible and address distinct concerns. With our Enzymes and Dandelion mix and our Stomach formula, we offer a complete range of products for the digestive sphere.
Is the taste strong?
Rest assured, absolutely not. The capsule form allows to limit the smell and to avoid the taste.
Where do our ingredients come from?
Encapsulation (capsule filling) - StrapharmSaint Hilaire de Loulay, France
For over 30 years, Strapharm has been an expert in the production of food supplements. Its know-how is based on the mastery of specific galenic forms.
Licorice extract, Gutgard® - Natural remedies Licorice origin: India - Manufacturing: India
Since 2000, Natural Remedies has been a key player in the Indian nutraceutical industry. The company strives to reconcile tradition and science by researching and magnifying the ingredients of Ayurvedic medicine.
Cactus and olive tree extract, Mucosave®- Bionap Cactus and olive tree origin: Italy - Manufacturing: Italy
Bionap uses plants from the Mount Etna region (Sicily) in the form of extracts concentrated in active compounds. Rich in polyphenols, the ingredient MucosaveTMFG® has been tested in 2 clinical studies of more than 100 subjects each.
Sage extract, Nexira Sage origin : Europe - Manufacturing : France
Focused on science and innovation, Nexira offers a wide range of food supplement ingredients based on a strong technological mastery, and rigorous quality and traceability.